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HTR6

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 6

  • Overview

    Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and they have a role in spatial learning and memory. The human 5-HT6 receptor gene has been localized to chromosome 1 (1p35-36).
  • Synonyms

    HTR6; 5-hydroxytryptamine (serotonin) receptor 6; 5-hydroxytryptamine receptor 6; 5 HT 6; 5 HT6; 5 hydroxytryptamine 6 receptor; 5 hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; 5HT 6; 5HT6R_HUMAN; HTR 6; Serotonin receptor 6;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Pan troglodytes (Chimpanzee)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR6-5331HCL Recombinant Human HTR6 293 Cell Lysate HEK293 N/A
Rat HTR6-2970R Recombinant Rat HTR6 Protein Mammalian Cell His
Rat HTR6-2625R-B Recombinant Rat HTR6 Protein Pre-coupled Magnetic Beads HEK293
Rat HTR6-2625R Recombinant Rat HTR6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL27554HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 6(Htr6) Protein, His-Tagged E.coli expression system His Full Length (1-440)
Mus musculus (Mouse) RFL1600MF Recombinant Full Length Mouse 5-Hydroxytryptamine Receptor 6(Htr6) Protein, His-Tagged E.coli expression system His Full Length (1-440)
Pan troglodytes (Chimpanzee) RFL18093PF Recombinant Full Length Pan Troglodytes 5-Hydroxytryptamine Receptor 6(Htr6) Protein, His-Tagged E.coli expression system His Full Length (1-440)
Rattus norvegicus (Rat) RFL35894RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 6(Htr6) Protein, His-Tagged E.coli expression system His Full Length (1-436)
Chicken HTR6-4069C Recombinant Chicken HTR6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HTR6 Related Articles
  • HTR6 Related Research Area

HTR6 involved in several pathways and played different roles in them. We selected most pathways HTR6 participated on our site, such as Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPRKACG;SLC8A2B;ADORA2AA;AVPR1B;ADRA1D;PRKACBA;HTR2A;ATP2A2B;ATP2B3B
cAMP signaling pathwayCALM1;F2R;MLLT4;RAP1A;RHOA;CALM3;ATP2B1;EP300;CNGA3
Neuroactive ligand-receptor interactionF2RL2;GABRA6;OPRM1;GRIN1;NTSR1;PTGER4B;CHRNA4B;NPY7R;ADRB3A
Serotonergic synapseCYP2C54;TPH1;GNG5;GABRB3;PLA2G4F;PLA2G4D;GNB2;HTR1B;HTR2B

HTR6 has several biochemical functions, for example, histamine receptor activity, protein binding, serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR6 itself. We selected most functions HTR6 had, and list some proteins which have the same functions with HTR6. You can find most of the proteins on our site.

Function Related Protein
histamine receptor activityHRH3;HRH2;HRH4;HTR6;HRH1
protein bindingNTN1;SLC9A3;SCRT1;POLM;CD63;NGDN;MAB21L1;AGR2;FLI1
serotonin receptor activityHTR4;HTR3E;HTR1AB;HTR2B;HTR1F;HTR1A;HTR3A;HTR1AA;HTR7

HTR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR6.

FYN; serotonin; lsd-lysergic acid diethylamide; fyn_crigr_protein

Hiram, R; Rizcallah, E; et al. Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-alpha, and IL-6 in the human pulmonary artery. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 307:H1547-H1558(2014).
Ivanenkov, YA; Majouga, AG; et al. Computational approaches to the design of novel 5-HT6R ligands. REVIEWS IN THE NEUROSCIENCES 25:451-467(2014).
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