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HTT

  • Official Full Name

    Htt huntingtin

  • Synonyms

    HTT; huntingtin; HD protein homolog; Huntington disease gene homolog; huntington disease protein homolog; Hd; Hdh; IT15; AI256365; C430023I11Rik;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • MBP
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTT-4637H Recombinant Human HTT Protein, GST-tagged Wheat Germ GST
Human HTT-28315TH Recombinant Human HTT Wheat Germ N/A 110 amino acids
Human HTT-1126H-B Recombinant Human HTT Protein Pre-coupled Magnetic Beads HEK293
Human HTT-3829H Recombinant Human HTT Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human HTT-3873H Recombinant Human HTT protein, His-tagged E.coli His 2845-3000 aa
Human HTT-2263H Recombinant Human HTT Protein, His-tagged E.coli N-His Thr803-Phe941
Human HTT-20HFL Recombinant Full Length Human HTT Protein, C-Flag-tagged Mammalian cells Flag
Human HTT-1313H Recombinant Human HTT protein E.coli N/A Met 1 - Glu 82
Human HTT-1536H Recombinant Human HTT protein, MBP-His-tagged E.coli MBP-His Met1-Glu82
Human HTT-1126H Recombinant Human HTT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Htt-1597M Recombinant Mouse Htt protein, His & GST-tagged E.coli His/GST Thr782~Phe920
Mouse Htt-1107M Recombinant Mouse Htt Protein, MYC/DDK-tagged HEK293T MYC/DDK
Zebrafish htt-3808D Recombinant ZHD, GST-tagged E.coli GST 494-604aa
Zebrafish HTT-8648Z Recombinant Zebrafish HTT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HTT Related Articles

HTT involved in several pathways and played different roles in them. We selected most pathways HTT participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Huntingtons diseaseRCOR1;NDUFC2-KCTD14;COX5B;COX6B2;NDUFA4L2;NDUFA1;DNAH11;SP1;NDUFS7

HTT has several biochemical functions, for example, beta-tubulin binding, dynactin binding, dynein intermediate chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTT itself. We selected most functions HTT had, and list some proteins which have the same functions with HTT. You can find most of the proteins on our site.

Function Related Protein
beta-tubulin bindingGABARAPL1;GABARAPL2;SLC6A2;MAP1S;TRPV4;ADNP;B4GALT1;GABARAP;OST4
dynactin bindingBICD1;CCDC64;BBS4;PROL1;SNX6;HTT;SNX5
dynein intermediate chain bindingHEATR2;HTT;PAFAH1B1;RAN
identical protein bindingCDC42BPA;STAT2;BRAF;LCK;ATL2;CBY1;VEGFA;TRADD;PTPRM
ion channel bindingYWHAH;SCN5A;FYN;FAM115A;ACTN3;FKBP1A;KCNE1L;YES1;CAV3
p53 bindingMDM2;EHMT2;SIRT1;BRD7;ZFP385C;PSME3;SETD7;TRP63;NUAK1
profilin bindingDIAP1;FMNL1;EVL;PCLO;WIPF1;CTTN;RHOQ;VASP;DIAPH1
protein bindingPC;JAM2;GPSM2;PLCB4;VEGFA;MIS18A;FFAR2;PBX1;SUV39H2
receptor bindingCXCL1;PTK2AB;FKBP1B;EDA;PLA2G1B;PARK7;POU2F1;INHA;CTNND1
transcription factor bindingSOX17;HDAC1;PPP1R13BA;NIF3L1;TMEM173;PAX2;RARA;H2-AB1;RBFOX2

HTT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTT here. Most of them are supplied by our site. Hope this information will be useful for your research of HTT.

PRPF40A; SH3GL3

Fodale, V; Kegulian, NC; et al. Polyglutamine- and Temperature-Dependent Conformational Rigidity in Mutant Huntingtin Revealed by Immunoassays and Circular Dichroism Spectroscopy. PLOS ONE 9:-(2014).
Yao, J; Ong, SE; et al. Huntingtin is associated with cytomatrix proteins at the presynaptic terminal. MOLECULAR AND CELLULAR NEUROSCIENCE 63:96-100(2014).
  • Q&As
  • Reviews

Q&As (6)

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What diseases is HTT associated with? 11/08/2022

HTT is associated with neurodegenerative diseases such as Huntington's disease, Parkinson's disease, and Alzheimer's disease.

How can animal models be used to study the function and disease mechanism of HTT protein? 10/11/2021

Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role of HTT protein in vivo and disease mechanisms. These animal models can be used to study the effects of HTT proteins on neuronal function, synaptic transmission, behavior, and more, as well as to evaluate the effects of potential therapeutic strategies.

What are the therapeutic strategies for HTT protein? 08/19/2021

Therapeutic strategies for HTT protein include inhibiting its expression, reducing its activity, or changing its modification state. A number of small molecule inhibitors and gene therapy strategies targeting HTT proteins are currently being studied.

Is there a challenge in HTT protein research? 03/19/2021

There are still some challenges in the research of HTT proteins, such as the need to better understand their structure and functional relationships, and develop more effective drugs or treatments. In addition, due to the complexity and individual differences of neurodegenerative diseases, therapeutic strategies targeting HTT proteins also need to be adapted and optimized according to individual conditions.

How does HTT protein interact with other proteins or signaling pathways? 11/04/2020

HTT protein can interact with other proteins and signaling pathways. For example, HTT proteins can interact with transcription factors to affect gene transcription, and can also interact with signaling pathways such as MAPK (mitogen-activated protein kinase) to participate in cell proliferation and apoptosis.

How can HTT protein be used for disease diagnosis? 06/09/2020

By measuring the expression level and modification status of HTT protein, it can be used to diagnose diseases such as Huntington's disease. At present, there are some detection methods for HTT protein, such as western blotting, immunohistochemistry, etc.

Customer Reviews (3)

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Reviews
06/24/2021

    This protein synthesis process is efficient and reliable, reducing experimental time and cost.

    02/20/2021

      This product has strict quality control and complies with relevant industry standards.

      09/08/2020

        When experiments were performed with this protein, the sensitivity and accuracy of the experiments were significantly improved.

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