HTT
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Official Full Name
Htt huntingtin
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Synonyms
HTT; huntingtin; HD protein homolog; Huntington disease gene homolog; huntington disease protein homolog; Hd; Hdh; IT15; AI256365; C430023I11Rik;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- MBP
- MYC
- DDK
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HTT-4637H | Recombinant Human HTT Protein, GST-tagged | Wheat Germ | GST | ||
Human | HTT-28315TH | Recombinant Human HTT | Wheat Germ | N/A | 110 amino acids | |
Human | HTT-1126H-B | Recombinant Human HTT Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | HTT-3829H | Recombinant Human HTT Protein, MYC/DDK-tagged | HEK293T | Myc/DDK | ||
Human | HTT-3873H | Recombinant Human HTT protein, His-tagged | E.coli | His | 2845-3000 aa | |
Human | HTT-2263H | Recombinant Human HTT Protein, His-tagged | E.coli | N-His | Thr803-Phe941 | |
Human | HTT-20HFL | Recombinant Full Length Human HTT Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | HTT-1313H | Recombinant Human HTT protein | E.coli | N/A | Met 1 - Glu 82 | |
Human | HTT-1536H | Recombinant Human HTT protein, MBP-His-tagged | E.coli | MBP-His | Met1-Glu82 | |
Human | HTT-1126H | Recombinant Human HTT Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Htt-1597M | Recombinant Mouse Htt protein, His & GST-tagged | E.coli | His/GST | Thr782~Phe920 | |
Mouse | Htt-1107M | Recombinant Mouse Htt Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Zebrafish | htt-3808D | Recombinant ZHD, GST-tagged | E.coli | GST | 494-604aa | |
Zebrafish | HTT-8648Z | Recombinant Zebrafish HTT | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- HTT Related Articles
HTT involved in several pathways and played different roles in them. We selected most pathways HTT participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Huntingtons disease | SIN3A;NDUFB10;NDUFA1;TBPL2;PPARGC1A;NDUFB11;DNAH11;NDUFB1;ATP5J |
HTT has several biochemical functions, for example, beta-tubulin binding, dynactin binding, dynein intermediate chain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTT itself. We selected most functions HTT had, and list some proteins which have the same functions with HTT. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
beta-tubulin binding | FGF13;RGS2;PROL1;BBS4;LRPPRC;NDEL1;GABARAP;ADNP;CASC1 |
dynactin binding | SNX6;BICD1;CCDC64;PROL1;HTT;BBS4;SNX5 |
dynein intermediate chain binding | PAFAH1B1;HTT;HEATR2;RAN |
identical protein binding | ALDH4A1;ABCD1;C10orf88;SMAD6;ATXN10;BNIP3L;GPR50;BRI3;ASS1 |
ion channel binding | CALM1;HSP90AB1;FHL1;KCNE2;FKBP1A;PACS1A;KCNIP2;ASPH;EPN1 |
p53 binding | SMARCA4;RNF34;ZFP385C;BLM;CDKN2A;ZFP346;ZNF346;TAF3;PLK3 |
profilin binding | WIPF1;DIAPH1;CTTN;DIAP1;RHOQ;VASP;CYFIP1;FMNL1;HTT |
protein binding | RAB11FIP3;ATP6AP2;VAC14;THOC7;IRAK1BP1;ZBTB4;POLR1C;SMC2;RFESD |
receptor binding | CD160;MLN;CXCL12;ITGA1;FGF24;ADIPOQ;TAC4;PVRL3;PVRL2L |
transcription factor binding | LMO4;NKX3-1;FOXA2;ARNT;PIAS2;NAAA;JUNBB;PPP1R13B;FOXA1 |
HTT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTT here. Most of them are supplied by our site. Hope this information will be useful for your research of HTT.
PRPF40A; SH3GL3
- Q&As
- Reviews
Q&As (6)
Ask a questionHTT is associated with neurodegenerative diseases such as Huntington's disease, Parkinson's disease, and Alzheimer's disease.
Animal models carrying human mutant genes can be constructed using transgenic or gene editing technology to study the role of HTT protein in vivo and disease mechanisms. These animal models can be used to study the effects of HTT proteins on neuronal function, synaptic transmission, behavior, and more, as well as to evaluate the effects of potential therapeutic strategies.
Therapeutic strategies for HTT protein include inhibiting its expression, reducing its activity, or changing its modification state. A number of small molecule inhibitors and gene therapy strategies targeting HTT proteins are currently being studied.
There are still some challenges in the research of HTT proteins, such as the need to better understand their structure and functional relationships, and develop more effective drugs or treatments. In addition, due to the complexity and individual differences of neurodegenerative diseases, therapeutic strategies targeting HTT proteins also need to be adapted and optimized according to individual conditions.
HTT protein can interact with other proteins and signaling pathways. For example, HTT proteins can interact with transcription factors to affect gene transcription, and can also interact with signaling pathways such as MAPK (mitogen-activated protein kinase) to participate in cell proliferation and apoptosis.
By measuring the expression level and modification status of HTT protein, it can be used to diagnose diseases such as Huntington's disease. At present, there are some detection methods for HTT protein, such as western blotting, immunohistochemistry, etc.
Customer Reviews (3)
Write a reviewThis protein synthesis process is efficient and reliable, reducing experimental time and cost.
This product has strict quality control and complies with relevant industry standards.
When experiments were performed with this protein, the sensitivity and accuracy of the experiments were significantly improved.
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