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HUS1

  • Official Full Name

    HUS1 checkpoint homolog

  • Overview

    The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
  • Synonyms

    HUS1; HUS1 checkpoint homolog (S. pombe); HUS1 (S. pombe) checkpoint homolog; checkpoint protein HUS1; hus1+ like protein; hus1+-like protein; hHUS1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HUS1-3364H Recombinant Human HUS1, His-tagged E.coli His
Human HUS1-29414TH Recombinant Human HUS1, His-tagged E.coli His 280 amino acids
Human HUS1-5327HCL Recombinant Human HUS1 293 Cell Lysate HEK293 N/A
Human HUS1-1572H Recombinant Human HUS1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HUS1-5225H Recombinant Human HUS1 Protein, GST-tagged Wheat Germ GST
Human HUS1-3059H Recombinant Human HUS1 protein, His-SUMO-tagged E.coli His-SUMO 2-280aa
Human HUS1-5720HF Recombinant Full Length Human HUS1 Protein, GST-tagged In Vitro Cell Free System GST 280 amino acids
Human HUS1-3294H Recombinant Human HUS1 Protein (Met1-Ser280), N-His tagged E.coli N-His Met1-Ser280
Mouse HUS1-7948M Recombinant Mouse HUS1 Protein Mammalian Cell His
Mouse HUS1-4386M Recombinant Mouse HUS1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hus1-1201M Recombinant Mouse Hus1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse HUS1-4386M-B Recombinant Mouse HUS1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HUS1 Related Articles

HUS1 involved in several pathways and played different roles in them. We selected most pathways HUS1 participated on our site, such as Activation of ATR in response to replication stress, Cell Cycle, Cell Cycle Checkpoints, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of ATR in response to replication stressRAD17;RAD9;RAD9B;MCM10;CHEK1;CLSPN;MCM8;HUS1;RAD1
Cell CycleAHCTF1;GORASP2;RAD9B;RAD9;GINS2;MSH5;NSL1;MCM9;YWHAH
Cell Cycle CheckpointsCHEK2;BABAM1;THRSP;BRCC3;UIMC1;HTATIP;RAD1;RAD17;BRE
DNA Double-Strand Break RepairCLSPN;RTEL1;TIMELESS;EME1;RAD9;EYA4;PPP4CB;WRN;GEN1
DNA RepairPARP2;RNF4;DTL;CLSPN;TDP1;RAD17;APITD1;RBBP8;DNA2
G2/M CheckpointsBABAM1;RAD17;RNF168;BRCC3;BARD1;THRSP;RAD1;RAD9;RAD9A
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)HUS1;BRE;TP53BP1;RAD51AP1;UIMC1;TIMELESS;BABAM1;RNF4;KIAA0146
HDR through Homologous Recombination (HRR)RAD9B;EME1;GEN1;EME2;TOPBP1;RAD51AP1;KIAA0146;RAD9;RBBP8

HUS1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HUS1 itself. We selected most functions HUS1 had, and list some proteins which have the same functions with HUS1. You can find most of the proteins on our site.

Function Related Protein
protein bindingCRYBB3;MIF;ZNF652;C16orf48;NECAB2;USP17L2;PLAT;ANKRD45;DDI1

HUS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HUS1.

RAD1; RAD9A; PSD; HPRT1; ALDOB; PSMA2; YWHAZ; STRAP; CD200

Bozdarov, J; Sherry, JP; et al. The rad1 gene in Rainbow Trout (Oncorhynchus mykiss) is highly conserved and may express proteins from non-canonical spliced isoforms. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 157:16-23(2013).
Saberi, A; Nakahara, M; et al. The 9-1-1 DNA clamp is required for immunoglobulin gene conversion. MOLECULAR AND CELLULAR BIOLOGY 28:6113-6122(2008).
  • Q&As
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