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HVCN1

  • Official Full Name

    hydrogen voltage-gated channel 1

  • Overview

    This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system.;Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process;facilitates antibody production. This same channel protein, however, can also regulate functions in other cells;including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    HVCN1; hydrogen voltage-gated channel 1; voltage-gated hydrogen channel 1; Hv1; MGC15619; voltage sensor domain only protein; VSOP; voltage sensor domain-only protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis)
  • Danio rerio (Zebrafish) (Brachydanio rerio)
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HVCN1-14017H Recombinant Human HVCN1, GST-tagged E.coli GST 1-103a.a.
Human HVCN1-340HCL Recombinant Human HVCN1 lysate HEK293 N/A
Human HVCN1-1410H Recombinant Human HVCN1 protein, His-tagged E.coli His Met1~Val138
Human HVCN1-5722HF Recombinant Full Length Human HVCN1 Protein In Vitro Cell Free System 481 amino acids
Human HVCN1-2195H Recombinant Human HVCN1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HVCN1-5224H Recombinant Human HVCN1 Protein Wheat Germ N/A
Mouse HVCN1-7951M Recombinant Mouse HVCN1 Protein Mammalian Cell His
Mouse HVCN1-4387M Recombinant Mouse HVCN1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hvcn1-2437M Recombinant Mouse Hvcn1 Full Length Transmembrane protein, His-tagged In vitro E. coli expression system His 1-269aa
Mouse Hvcn1-3463M Recombinant Mouse Hvcn1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HVCN1-4387M-B Recombinant Mouse HVCN1 Protein Pre-coupled Magnetic Beads HEK293
Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) RFL31952CF Recombinant Full Length Ciona Intestinalis Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-342)
Danio rerio (Zebrafish) (Brachydanio rerio) RFL14119DF Recombinant Full Length Danio Rerio Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-235)
Gallus gallus (Chicken) RFL14777GF Recombinant Full Length Chicken Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-235)
Homo sapiens (Human) RFL11608HF Recombinant Full Length Human Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-273)
Mus musculus (Mouse) RFL11324MF Recombinant Full Length Mouse Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-269aa)
Xenopus laevis (African clawed frog) RFL30819XF Recombinant Full Length Xenopus Laevis Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-230)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL10850XF Recombinant Full Length Xenopus Tropicalis Voltage-Gated Hydrogen Channel 1(Hvcn1) Protein, His-Tagged E.coli expression system His Full Length (1-230)
Zebrafish HVCN1-494Z Recombinant Zebrafish HVCN1 Mammalian Cell His
Chicken HVCN1-2368C Recombinant Chicken HVCN1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HVCN1 Related Articles

HVCN1 involved in several pathways and played different roles in them. We selected most pathways HVCN1 participated on our site, such as Fertilization, Reproduction, Sperm Motility And Taxes, which may be useful for your reference. Also, other proteins which involved in the same pathway with HVCN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FertilizationCATSPERG2;CATSPERG1;ADAM21;CATSPER1;TMEM146;OVGP1;CATSPER2;Acr;ZP2
ReproductionADAM2;ADAM30;CATSPERG1;CATSPERG2;ZP3;TMEM146;CATSPER1;OVGP1;CATSPER3
Sperm Motility And TaxesCATSPERB;CATSPER1;HVCN1;CATSPER2;CATSPERG1;CATSPERG2;CATSPER3;TMEM146

HVCN1 has several biochemical functions, for example, voltage-gated cation channel activity, voltage-gated proton channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HVCN1 itself. We selected most functions HVCN1 had, and list some proteins which have the same functions with HVCN1. You can find most of the proteins on our site.

Function Related Protein
voltage-gated cation channel activityHVCN1;GRIK1;PKD2;GRIN1;GRIN2A
voltage-gated proton channel activityHVCN1;NOX1

HVCN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HVCN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HVCN1.

Sasaki, M; Tojo, A; et al. Autoimmune disorder phenotypes in Hvcn1-deficient mice. BIOCHEMICAL JOURNAL 450:295-301(2013).
Demaurex, N; El Chemaly, A; et al. Physiological roles of voltage-gated proton channels in leukocytes. JOURNAL OF PHYSIOLOGY-LONDON 588:4659-4665(2010).
Capasso, M; Bhamrah, MK; et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. NATURE IMMUNOLOGY 11:265-U12(2010).
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