hyal3
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  • Official Full Name
  • hyaluronoglucosaminidase 3
  • Background
  • This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
  • Synonyms
  • HYAL3; hyaluronoglucosaminidase 3; hyaluronidase-3; LUCA 3; LUCA14; Minna14; Hyal-3; HYAL3_HUMAN; Hyaluronidase 3; Hyaluronoglucosaminidase-3; LUCA-3; LUCA3; Lung carcinoma protein 3; OTTHUMP00000211052; OTTHUMP00000211054; OTTHUMP00000219781
Cat.#:HYAL3-5220HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HYAL3 Protein, GST-tagged
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Cat.#:HYAL3-14020HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HYAL3, His-tagged
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Cat.#:HYAL3-7954MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HYAL3 Protein
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Cat.#:HYAL3-2976RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat HYAL3 Protein
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Cat.#:HYAL3-6839ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HYAL3
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Cat.#:HYAL3-831HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HYAL3 cell lysate
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Involved Pathway

HYAL3 involved in several pathways and played different roles in them. We selected most pathways HYAL3 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan degradation
IDS; HYAL2; GNSA; HEXA; HYAL6; HEXB; GNSB; HYAL3; HPSE2; HYAL4
Metabolic pathways
PFAS; PCYT2; ST3GAL3B; TSTA3; NME4; DGAT1; OGDHL; OXSR1; COX5B; POLE

Protein Function

HYAL3 has several biochemical functions, for example, hyaluronoglucuronidase activity, hyalurononglucosaminidase activity, NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL3 itself. We selected most functions HYAL3 had, and list some proteins which have the same functions with HYAL3. You can find most of the proteins on our site.
Function
Related Protein
Function hyaluronoglucuronidase activity
Related Protein HYAL2; HYAL3
Function hyalurononglucosaminidase activity
Related Protein HYAL1; CD44; SPAM1; MGEA5; KIAA1199; HYAL6; HYAL4; HYAL3; HYAL2
Function NOT hyalurononglucosaminidase activity
Related Protein HYAL1; HYAL3; HYAL2
Function protein binding
Related Protein Anks6; Chrng; SHISA5; LZTS2; LILRB4; LGALS2; MEA1; PPIG; SAP30L; DNAJB6
Function NOT virus receptor activity
Related Protein HYAL1; HYAL3

Interacting Protein

HYAL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL3.
DAB1; SLC22A2

HYAL3 Related Articles

Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).
Lokeshwar, VB; Schroeder, GL; et al. Regulation of hyaluronidase activity by alternative mRNA splicing. JOURNAL OF BIOLOGICAL CHEMISTRY 277:33654-33663(2002).