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HYAL3

  • Official Full Name

    hyaluronoglucosaminidase 3

  • Overview

    This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon.
  • Synonyms

    HYAL3; hyaluronoglucosaminidase 3; hyaluronidase-3; LUCA 3; LUCA14; Minna14; Hyal-3; HYAL3_HUMAN; Hyaluronidase 3; Hyaluronoglucosaminidase-3; LUCA-3; LUCA3; Lung carcinoma protein 3; OTTHUMP00000211052; OTTHUMP00000211054; OTTHUMP00000219781;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HYAL3-14020H Recombinant Human HYAL3, His-tagged E.coli His 1-350a.a.
Human HYAL3-831HCL Recombinant Human HYAL3 cell lysate N/A
Human HYAL3-5220H Recombinant Human HYAL3 Protein, GST-tagged Wheat Germ GST
Human HYAL3-5727HF Recombinant Full Length Human HYAL3 Protein, GST-tagged In Vitro Cell Free System GST 417 amino acids
Mouse HYAL3-7954M Recombinant Mouse HYAL3 Protein Mammalian Cell His
Mouse HYAL3-4390M Recombinant Mouse HYAL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HYAL3-4390M-B Recombinant Mouse HYAL3 Protein Pre-coupled Magnetic Beads HEK293
Rat HYAL3-2976R Recombinant Rat HYAL3 Protein Mammalian Cell His
Rat HYAL3-2631R-B Recombinant Rat HYAL3 Protein Pre-coupled Magnetic Beads HEK293
Rat HYAL3-2631R Recombinant Rat HYAL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish HYAL3-6839Z Recombinant Zebrafish HYAL3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HYAL3 Related Articles

HYAL3 involved in several pathways and played different roles in them. We selected most pathways HYAL3 participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYAL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosaminoglycan degradationHEXA;NAGLU;HGSNAT;HYAL1;HEXB;GNSA;HPSE;SGSH;ARSB
Metabolic pathwaysHPSE;ADH2-1;ST3GAL2;ATP6V1D;COX5A;PLA2G7;COQ2;NDUFV2;PFKMB

HYAL3 has several biochemical functions, for example, hyaluronoglucuronidase activity, hyalurononglucosaminidase activity, NOT hyalurononglucosaminidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HYAL3 itself. We selected most functions HYAL3 had, and list some proteins which have the same functions with HYAL3. You can find most of the proteins on our site.

Function Related Protein
hyaluronoglucuronidase activityHYAL2;HYAL3
hyalurononglucosaminidase activityHYAL4;SPAM1;HYAL3;CD44;HYAL1;HYAL2;KIAA1199;HYAL6;MGEA5
NOT hyalurononglucosaminidase activityHYAL2;HYAL1;HYAL3
protein bindingBICC1;HCST;CCNE2;DSG1A;FAM164C;RAB39B;CPNE1;MARK2;ANK2
NOT virus receptor activityHYAL3;HYAL1

HYAL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYAL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYAL3.

DAB1; SLC22A2

Prando, ED; Cavalli, LR; et al. Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines. EPIGENETICS 6:1413-1424(2011).
Lokeshwar, VB; Schroeder, GL; et al. Regulation of hyaluronidase activity by alternative mRNA splicing. JOURNAL OF BIOLOGICAL CHEMISTRY 277:33654-33663(2002).
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