hyou1
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  • Official Full Name
  • hypoxia up-regulated 1
  • Background
  • The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription;start sites. A cis-acting segment found in the 5 UTR is involved in stress-dependent induction, resulting in the;accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this;gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein;is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in;hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast;tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation;site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is;only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the;cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by;an amino-terminal targeting signal.
  • Synonyms
  • HYOU1; hypoxia up-regulated 1; hypoxia up-regulated protein 1; glucose regulated protein 170; Grp170; HSP12A; ORP150; glucose-regulated protein 170; 150 kDa oxygen-regulated protein; oxygen regulated protein (150kD); 170 kDa glucose-regulated protein; GRP; GRP-170; ORP-150
Cat.#:HYOU1-5215HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HYOU1 Protein, GST-tagged
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Cat.#:HYOU1-30518THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HYOU1, His-tagged
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Cat.#:HYOU1-3255HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human HYOU1, His tagged
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Cat.#:HYOU1-7961MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HYOU1 Protein
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Cat.#:HYOU1-1725CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HYOU1
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Cat.#:HYOU1-11978ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HYOU1
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Cat.#:HYOU1-2295HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human HYOU1 cell lysate
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Involved Pathway

HYOU1 involved in several pathways and played different roles in them. We selected most pathways HYOU1 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, IRE1alpha activates chaperones, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYOU1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Binding and Uptake of Ligands by Scavenger Receptors
APOBB.1; IGKV1-5; STAB2; HP; HPX; HYOU1; SCGB3A2; CD163; Alb; APOA1B
IRE1alpha activates chaperones
YIF1A; PDIA6; HYOU1; C19orf10; PREB; HDGF; CTDSP2; FKBP14; ADD1; CXXC1
Metabolism of proteins
SPON1; TOMM7; CPB2; KIFC3; C19orf10; TRAPPC9; SAE1; TRAPPC6B; GPR116; MPDU1B
Protein processing in endoplasmic reticulum
BAX; PDIP5; UBE2E1; HSPA2; BAXA; EIF2AK4; MARCH6; VCP; GANAB; UBQLN2
Scavenging by Class F Receptors
HSPH1; HYOU1
Unfolded Protein Response (UPR)
PDIA6; CTDSP2; SERP1; YY2; ASNA1; WIPI1; SEC63; KLHDC3; DNAJB9; CXXC1
Vesicle-mediated transport
HSPH1; AP1S3A; SCFD1; HYOU1; HIP1R; GJB5; COPB2; MIA3; ARCN1B; SEC16B
XBP1(S) activates chaperone genes
CXXC1; C19orf10; FKBP14; DNAJB9; TPP1; YIF1A; PDIA6; SERP1; KLHDC3; HYOU1

Protein Function

HYOU1 has several biochemical functions, for example, ATP binding, chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HYOU1 itself. We selected most functions HYOU1 had, and list some proteins which have the same functions with HYOU1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PIM3; PFKFB4L; TTLL12; RIPK1; UBE2L3A; MARK3; PL10; CERK; NEK12; UBE2I
Function chaperone binding
Related Protein CDC37; DNAJB8; HSCB; AMFR; ATP1A3; BAK1; C1orf182; DNAJC3; TBCD; BIRC5

Interacting Protein

HYOU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYOU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYOU1.
SGK1; MCC; HLA-A; HLA-A; VHL; ARF6; IKBKE; EXT2; TNFRSF10D; TRAF6; ere_dna; cona_canen; ESR1; GBA; env; Itgb1; HSPA5; H2AFX; NSS