hdc
Share
  • Official Full Name
  • histidine decarboxylase
  • Background
  • This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.
  • Synonyms
  • HDC; histidine decarboxylase; MGC163399
Cat.#:HDC-2110HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human HDC Protein (1-662 aa), His-tagged
+Inquiry
Cat.#:HDC-4654HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human HDC Protein, GST-tagged
+Inquiry
Cat.#:HDC-495HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human HDC Protein, His-tagged
+Inquiry
Cat.#:Hdc-496MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Hdc Protein, His-tagged
+Inquiry
Cat.#:Hdc-497RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Hdc Protein, His-tagged
+Inquiry
Cat.#:HDC-230HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human HDC
+Inquiry
Cat.#:HDC-7536MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse HDC Protein
+Inquiry
Cat.#:HDC-5573CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken HDC
+Inquiry
Cat.#:HDC-5929ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish HDC
+Inquiry
Cat.#:HDC-5600HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human HDC 293 Cell Lysate
+Inquiry

Involved Pathway

HDC involved in several pathways and played different roles in them. We selected most pathways HDC participated on our site, such as Histidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Histidine metabolism
ALDH3A2A; CARNS1; ALDH2; CNDP1; ALDH1B1; HAL; ALDH9A1B; MAOB; ALDH1A3; ABP1
Metabolic pathways
TUSC3; TKTL2; NADKA; ALG9; MTMR14; NAT2; OLAH; ATP5G1; ATP5IB; NDUFB4

Protein Function

HDC has several biochemical functions, for example, histidine decarboxylase activity, protein binding, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDC itself. We selected most functions HDC had, and list some proteins which have the same functions with HDC. You can find most of the proteins on our site.
Function
Related Protein
Function histidine decarboxylase activity
Related Protein HDC
Function protein binding
Related Protein WTIP; MDFI; DNTT; ATP6V1F; NLRP12; IRAK2; RHOG; OAS1B; CTNNBL1; SERPING1
Function pyridoxal phosphate binding
Related Protein GPT2L; GOT2B; CTH; ETNPPL; GPT2; CSAD; GAD1; SPTLC1; PHYKPL; GOT1L1

Interacting Protein

HDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDC here. Most of them are supplied by our site. Hope this information will be useful for your research of HDC.
DTX2; DTX2

HDC Related Articles

Schneider, EH; Neumann, D; et al. Modulation of behavior by the histaminergic system: Lessons from HDC-, H3R- and H4R-deficient mice. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 47:101-121(2014).
Caro-Astorga, J; Fajardo, I; et al. Nascent histamine induces alpha-synuclein and caspase-3 on human cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 451:580-586(2014).