Hmox1
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Official Full Name
heme oxygenase (decycling) 1
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Overview
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. -
Synonyms
32 kD; bK286B10; D8Wsu38e; heat shock protein 32 kD; heat shock protein 32kD; Heat shock protein; Heme oxygenase (decycling) 1; Heme oxygenase 1; Hemox; HMOX 1; Hmox; HMOX1; HMOX1_HUMAN; HO 1; HO; HO-1; HO1; Hsp32;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Chicken
- Human
- Mouse
- Pig
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|MBP
- His|S
- His|T7
- B2M
- Myc
- DDK
- MYC
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- Hmox1 Related Articles
- Hmox1 Related Research Area
Hmox1 involved in several pathways and played different roles in them. We selected most pathways Hmox1 participated on our site, such as Porphyrin and chlorophyll metabolism, HIF- signaling pathway, Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with Hmox1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Porphyrin and chlorophyll metabolism | UGT2A2;UGT1A7;UGT2A3;HEPH;HMBSB;BLVRB;HCCSA.1;UGT1A7C;UGT1AB |
HIF- signaling pathway | EIF4E2;IFNGR1;HK3;ANGPT1;HK2;TEK;INSR;PRKCB;PRKCG |
Mineral absorption | ATP1B4;MT1B;ATP1B2;HEPH;SLC8A1;S100G;STEAP1;TRPM6;SLC46A1 |
MicroRNAs in cancer | CDC25A;BCL2;TIMP3;PRKCG;NOTCH2;CCNE1;Pdgfa&Pdgfb;RHOA;ROCK1 |
Hmox1 has several biochemical functions, for example, enzyme binding, heme binding, heme oxygenase (decyclizing) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Hmox1 itself. We selected most functions Hmox1 had, and list some proteins which have the same functions with Hmox1. You can find most of the proteins on our site.
Function | Related Protein |
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enzyme binding | ACAT1;SUPT5H;JUND;NKX2-1;USF1;HIST1H2AI;Il6ra;HNRNPUL1;SLC27A2 |
heme binding | CYP2F2;CYP26C1;CYP2A4;PTGS1;CYB5B;CYP4F3;CYP1C2;CYP2P9;CYP4A10 |
heme oxygenase (decyclizing) activity | HMOX2A;HMOX1A;HMOX1B;HMOX1;HMOX2 |
metal ion binding | ZBTB22;BRD1B;ARSJ;PDE11A;MMP23BB;AMPD1;DPYD;ZFP354B;RAB11FIP3 |
phospholipase D activity | PLD1;GPLD1;HMOX1;PLD1A;PLD4;PLD3;PLD2 |
protein binding | NR1D1;CD160;ADAM1B;MIS12;PELI2;USP42;ESRRA;TCEB3B;COMMD6 |
protein homodimerization activity | CRYBA1;ANXA1;ADRB2;FZD1;XPA;SMAD3;TLR13;ZHX2;PRDX4 |
signal transducer activity | DKK1;PKP1;MADD;MGAA;EDNRBA;OR115-6;TAAR15;PLCH2;NFKBIB |
Hmox1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Hmox1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Hmox1.
POT1; CREB3; ASL; TERF1; proS; q7ckk6_yerpe; hemL2; comEA; yvaE; gcvP
- Q&As
- Reviews
Q&As (5)
Ask a questionHMOX1 modulates the immune response during infectious diseases, influencing host-pathogen interactions. Its induction can contribute to an anti-inflammatory environment and impact the outcome of infections.
HMOX1 regulates iron homeostasis by releasing free iron during heme degradation. Its interaction with iron-responsive elements influences cellular iron levels and responses to iron availability.
HMOX1 is linked to oxidative stress-induced autophagy, contributing to cellular adaptation and survival. This connection influences the cellular response to stressors by promoting self-cleaning mechanisms.
HMOX1 plays a role in vascular health by protecting endothelial cells. Its anti-inflammatory and vasodilatory effects contribute to cardiovascular protection and may have implications for disease prevention.
HMOX1 modulates the immune response by suppressing inflammation. It inhibits pro-inflammatory pathways by influencing transcription factors and inhibiting the production of inflammatory mediators.
Customer Reviews (3)
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