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HECW1

Official Full Name

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Synonyms

HECW1;HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1;22195;ENSG00000002746;NEDL1;7p13;KIAA0322;E3 ubiquitin-protein ligase HECW1;E3 ubiquitin-protein ligase HECW1;HECT type E3 ubiquitin ligase;NEDD4-like ubiquitin-protein ligase 1;NEDD4-like E3 ubiquitin-protein ligase 1;HECT, C2 and WW domain-containing protein 1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HECW1-13728H	Recombinant Human HECW1, His-tagged	E.coli	His	1-350a.a.	$319 / 25ug
Mouse	HECW1-7563M	Recombinant Mouse HECW1 Protein	Mammalian Cell	His		Inquiry
Mouse	HECW1-4114M-B	Recombinant Mouse HECW1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	HECW1-4114M	Recombinant Mouse HECW1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	HECW1-2063R	Recombinant Rhesus monkey HECW1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	HECW1-1884R	Recombinant Rhesus Macaque HECW1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	HECW1-1884R-B	Recombinant Rhesus Macaque HECW1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
HECW1 Related Articles

HECW1 involved in several pathways and played different roles in them. We selected most pathways HECW1 participated on our site, such as Degradation of DVL, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with HECW1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Degradation of DVL	DVL3;DACT1;HECW1B;DVL1;DVL2;KLHL12;HECW1
Signal Transduction	USP9;SCT;PTPRU;STRA6;RSPO4;OPN4A;OTULIN;ANXA1A;PCSK5
Signaling by Wnt	TMED5;SOX9A;SRY;LGR6;TNKS;USP34;HECW1B;TNKS2;TLE3B
TCF dependent signaling in response to WNT	RNF43;SOX4A;CCDC88C;CDC73;KLHL12;RBBP5;RSPO1;TLE3B;PYGO1

HECW1 has several biochemical functions, for example, ligase activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HECW1 itself. We selected most functions HECW1 had, and list some proteins which have the same functions with HECW1. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	RNF31;PPIL2;UBE3B;UHRF1;MUL1A;PIAS3;MUL1;MARCH2;SIAH1A
ubiquitin protein ligase activity	UBE2G1;TRIM63;FANCL;RNF121;UBE2V1;RNF34;RNF175;WWP1;CBLL1

HECW1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HECW1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HECW1.

FBXL15; CACNA1A; GFI1B; USP7; MPHOSPH8

Zhi, X; Chen, CS; et al. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases. CELLULAR AND MOLECULAR LIFE SCIENCES 69:1425-1434(2012).

Li, Y; Zhou, Z; et al. WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer. ONCOGENE 28:2948-2958(2009).