Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

HEY2

  • Official Full Name

    hes-related family bHLH transcription factor with YRPW motif 2

  • Overview

    This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms

    HEY2; hes-related family bHLH transcription factor with YRPW motif 2; GRL; CHF1; HRT2; HERP1; HESR2; bHLHb32; GRIDLOCK; hairy/enhancer-of-split related with YRPW motif protein 2; HRT-2; hCHF1; hHRT2; HESR-2; protein gridlock homolog; HES-related repressor protein 1; HES-related repressor protein 2; hairy-related transcription factor 2; cardiovascular helix-loop-helix factor 1; class B basic helix-loop-helix protein 32; hairy and enhancer of split-related protein 2; cardiovascular basic helix-loop-helix factor 1; hairy/enhancer-of-split related with YRPW motif 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HEY2-279H Recombinant Human HEY2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HEY2-4717H Recombinant Human HEY2 Protein, GST-tagged Wheat Germ GST
Human HEY2-5574HCL Recombinant Human HEY2 293 Cell Lysate HEK293 N/A
Human HEY2-5992H Recombinant Human HEY2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HEY2-3529HF Recombinant Full Length Human HEY2 Protein, GST-tagged In Vitro Cell Free System GST 337 amino acids
Mouse Hey2-1119M Recombinant Mouse Hey2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque HEY2-2073R Recombinant Rhesus monkey HEY2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque HEY2-1894R Recombinant Rhesus Macaque HEY2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HEY2-1894R-B Recombinant Rhesus Macaque HEY2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HEY2-9160Z Recombinant Zebrafish HEY2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HEY2 Related Articles

HEY2 involved in several pathways and played different roles in them. We selected most pathways HEY2 participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEY2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsHEYL;ADAM10;CCNC;HDAC6;HDAC5;JAG1;MIB1;HEY2;HEY1
Constitutive Signaling by NOTCH1 PEST Domain MutantsCDK8;CCNC;JAG1;ADAM10;MIB1;HEY2;HDAC6;JAG2;HEYL
Delta-Notch Signaling PathwayASCL1A;TCF3B;JAG1;APPA;TUBB3;HES6;ASCL1;YY1;YY1A
DiseaseNUP50;TLR6;MMADHC;CPSF4;KPNA5;CCR5;AMN;WHSC2;TIRAP
Diseases of signal transductionOPN1MW;LRRFIP1;KREMEN2;OPN1SW;CTBP1;RBP1;FKBP1A;RBP4;HEYL
Heart DevelopmentNKX2;SMYD1;FOXC2;HEY1;IRX4;TBX20;FOXH1;GATA6;TBX5
NOTCH1 Intracellular Domain Regulates TranscriptionTLE2;HEY1;TUBB3;HEYL;TLE1;HEY2;TLE3;TLE4
Neural Crest DifferentiationTFAP2B;FOXD3;SOX5;OLIG2;ZIC1;DMBX1;CDH6;HOXA1;DLX5

HEY2 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, histone deacetylase binding, microsatellite binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HEY2 itself. We selected most functions HEY2 had, and list some proteins which have the same functions with HEY2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II activating transcription factor bindingBEX1;POU1F1;NEUROD1;EP300;SMAD3;HEY2;HNF4A;BHLHE40;CTNNB1
histone deacetylase bindingBCOR;USF1;ANKRD1;NIPBL;CRY1;MYOCD;BRMS1;SP1;CCND1
microsatellite bindingHEY1;HEY2;HEYL
protein bindingODF2;MAT2B;MYLK2;VPS25;SMN1;KAT8;FABP1;GGA2;KRT16
protein dimerization activityHER8A;ANO7;MXD3;HES4;DERL3;BHLHE41;POLR2J;ZBED6;ARNTL1B
sequence-specific DNA bindingHOXB1A;TP63;PPARA;NKX2.4A;GSX2;DMRTA2;DMBX1B;HOXB13;GLI1
transcription factor activity, RNA polymerase II core promoter sequence-specificHEY2;PAX7;TFAP2B;MEF2C;MAX;HEY1;HEYL;SMAD3;NKX3
transcription factor activity, protein bindingHEY1;HEYL;HEY2
transcription factor activity, sequence-specific DNA bindingZSCAN10;NFYB;ZNF812;FOXN3;ZNF498;POU5F3;IRF1B;HES1;TFDP1B
transcription factor bindingPIM1;LMO4;RNF4;PAX6;DRAP1;EP300;TRIB1;NFATC2;PSMC5

HEY2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEY2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HEY2.

TRAF1; RBPMS; SIRT1; HTT; PLSCR1; ENO1; ATXN1

Irshad, K; Mohapatra, SK; et al. A Combined Gene Signature of Hypoxia and Notch Pathway in Human Glioblastoma and Its Prognostic Relevance. PLOS ONE 10:-(2015).
Brandt, WD; Schreck, KC; et al. Notch Signaling Activation in Pediatric Low-Grade Astrocytoma. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:121-131(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All HEY2 Products

Required fields are marked with *

My Review for All HEY2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends