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HIP1

Official Full Name

huntingtin interacting protein 1
Overview

The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

HIP1; huntingtin interacting protein 1; huntingtin-interacting protein 1; ILWEQ; HIP-I; huntingtin-interacting protein I; MGC126506;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E. coli
E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HIP1-13782H	Recombinant Human HIP1, GST-tagged	E.coli	GST	435-764a.a.	$319 / 25ug
Human	HIP1-26095TH	Recombinant Human HIP1	Wheat Germ	N/A	110 amino acids	Inquiry
Human	HIP1-28314TH	Recombinant Human HIP1	Wheat Germ	N/A	1037 amino acids	Inquiry
Human	HIP1-4755H	Recombinant Human HIP1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HIP1-788HCL	Recombinant Human HIP1 cell lysate		N/A		Inquiry
Human	HIP1-1738H	Recombinant Human HIP1 protein, His & T7-tagged	E.coli	His/T7	Leu817~Glu1037 (Accession # O00291)	Inquiry
Human	HIP1-118H	Recombinant Human HIP1 protein, His-tagged	E. coli	His	435-764 aa	Inquiry
Human	HIP1-233HF	Recombinant Full Length Human HIP1 Protein	In Vitro Cell Free System		1037 amino acids	Inquiry
Human	HIP1-3474HF	Recombinant Full Length Human HIP1 Protein, GST-tagged	In Vitro Cell Free System	GST	1037 amino acids	Inquiry
Mouse	Hip1-5638M	Active Recombinant Mouse Huntingtin Interacting Protein 1, His-tagged	Mammalian cells	His		Inquiry
Mouse	HIP1-7634M	Recombinant Mouse HIP1 Protein	Mammalian Cell	His		Inquiry
Mouse	Hip1-4166M	Recombinant Mouse Hip1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Hip1-4166M-B	Recombinant Mouse Hip1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	HIP1-7597Z	Recombinant Zebrafish HIP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HIP1 Related Articles

HIP1 involved in several pathways and played different roles in them. We selected most pathways HIP1 participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Huntingtons disease	COX8C;UQCRH;NDUFB7;NDUFA4L2;DNAH14;DNALI1;COX7A1;COX8A;TBPL1

HIP1 has several biochemical functions, for example, actin binding, clathrin binding, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HIP1 itself. We selected most functions HIP1 had, and list some proteins which have the same functions with HIP1. You can find most of the proteins on our site.

Function	Related Protein
actin binding	MSRB2;CFL1;PAWR;CAPZA3;MYO5C;TNS1;MYO6;IPP;FSCN2
clathrin binding	SYT1;SYT1B;SYTL2;SYT10;SNAP91;PICALMB;AFTPHA;SYT11;SYT15
phosphatidylinositol binding	SLC12A9;HIP1R;RAG2;TULP2;ESYT2;SNX1B;PIK3C2B;PLD1;SNX33
protein binding	PPIA;LINGO1;FCRL4;ADAMTSL3;ZBTB5;PLAA;PJA1;UNC119;FAM101A
structural constituent of cytoskeleton	TUBA2;NGS;TUBB4B;SPTBN1;ARPC4;TUBB4A;PLS1;INA;GFAP

HIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HIP1.

HTT; CLTCL1; CLTC; REL; DAZAP2; AP2A1

Yan, R; Chen, MX; et al. Glycoprotein lb alpha clustering induces macrophage-mediated platelet clearance in the liver. THROMBOSIS AND HAEMOSTASIS 113:107-117(2015).

Masuda, T; Sakuma, C; et al. Spatiotemporal patterns of the Huntingtin-interacting protein 1-related gene in the mouse head. CONGENITAL ANOMALIES 53:141-148(2013).