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HSPA1B

  • Official Full Name

    heat shock 70kDa protein 1B

  • Overview

    This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
  • Synonyms

    HSPA1B; heat shock 70kDa protein 1B; heat shock 70kD protein 1B; heat shock 70 kDa protein 1A/1B; HSP70 2; HSP70-1/HSP70-2; HSP70.1/HSP70.2; heat shock 70 kDa protein 1/2; HSPA1A; HSP70-2; HSP70-1B; FLJ54328;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HSPA1B-5102H Recombinant Human HSPA1B Protein, GST-tagged Wheat Germ GST
Human HSPA1B-29401TH Recombinant Human HSPA1B N/A
Human HSPA1B-28995TH Recombinant Human HSPA1B E.coli N/A
Human HSPA1B-29397TH Recombinant Human HSPA1B E.coli N/A
Human HSPA1B-29402TH Recombinant Human HSPA1B E.coli N/A
Human HSPA1B-29395TH Recombinant Human HSPA1B, His-tagged E.coli His
Human HSPA1B-29399TH Recombinant Human HSPA1B, His-tagged His
Human HSPA1B-2623H Recombinant Human HSPA1B protein(381-610 aa), C-His-tagged E. coli C-His 381-610 aa
Mouse HSPA1B-7905M Recombinant Mouse HSPA1B Protein Mammalian Cell His
Mouse Hspa1b-403M Recombinant Mouse Hspa1b Protein, His-tagged E.coli His Met1~Asp642
Mouse HSPA1B-4355M Recombinant Mouse HSPA1B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HSPA1B-4355M-B Recombinant Mouse HSPA1B Protein Pre-coupled Magnetic Beads HEK293
Mouse Hspa1b-3057M Recombinant Mouse Hspa1b protein, His-SUMO-tagged E.coli His-SUMO 2-642aa
Cattle HSPA1B-402C Recombinant Cattle HSPA1B Protein, His-tagged E.coli His Met1~Asp641
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HSPA1B Related Articles

HSPA1B involved in several pathways and played different roles in them. We selected most pathways HSPA1B participated on our site, such as Spliceosome, MAPK signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
SpliceosomeSRSF1A;SNW1;HSPA1A;RBM17;HNRPK;PRPF3;TRA2A;PRPF18;SART1
MAPK signaling pathwayNTRK2;RPS6KAL;PLA2G4AA;NF1;FGF20;IL1B;CASP3A;MAPK12B;MAP2K3
Protein processing in endoplasmic reticulumDNAJB12;ATF4B1;STT3A;YOD1;SEC31B;SAR1AB;UBE2D1A;EIF2AK2;EIF2S1B
EndocytosisSH3GLB2A;DNM3;SH3GLB1;ARPC5B;ARRB2A;LDLRAP1A;EPN3;WASH1;VPS26B
Antigen processing and presentationHLA-DPB1;B2M;KLRC3;Ctsl;HLA-DQA1;CD4;HLA-DQB1;TAPBP;H2-Q10
Estrogen signaling pathwayFKBP5;NRAS;ESR1;KCNJ9;SOS1;ITPR1;GNAQ;PLCB4;KRAS
LegionellosisRELA;ITGAM;HSF1;CXCL1;IL1B;HSPD1;BCL2L13;EEF1A1;VCP
ToxoplasmosisSOCS1;IFNGR2;MAP2K6;BIRC3;HLA-DQB1;PDPK1;IFNG;CD40LG;TNF
MeaslesSTAT5A;PIK3R2;PRKCQ;CD46;IFNB1;IRAK1;Ifna15;NFKBIB;CD3E
Influenza AHLA-DRB5;IFNA6;HLA-DRB4;IRF7;IFNA5;IFNA16;IFNA7;GSK3B;HSPA6
Epstein-Barr virus infectionPOLR2A;PLCG1;STAT3;TBPL2;EP300;CSNK2A2;PSMD4;HDAC2;PRKACG

HSPA1B has several biochemical functions, for example, ATP binding, ATPase activity, ATPase activity, coupled. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA1B itself. We selected most functions HSPA1B had, and list some proteins which have the same functions with HSPA1B. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPGK1;CMPK;PIK3C2A;EHD2;IGF1RA;KIF3A;UCK1;PI4KA;AACS
ATPase activityABCF3;HSPA8;HSPA5;ATAD2;EIF4A1B;OLA1;KIF7;HSPA1B;ABCC5
ATPase activity, coupledPEX1;HSPA8;MYH3;HSPA6;HSPA1B;CCT8;VPS4A;HSPA1A;VPS4B
C3HC4-type RING finger domain bindingDNAJA1;HSPA8;PINK1;HSPA1B;KCNH2;HSPA1A
G-protein coupled receptor bindingGNAL;RSPO3;NPFFL;APLN;RSPO4;AKAP5;HAND2;INSL3;GHRL
enzyme bindingBCL10;HSPA6;DDX5;HMOX1;HINFP;IL6R;CSF3;DDC;Slc4a2
heat shock protein bindingSSUH2RS1;CDC37;HSPA1B;DNAJA4;KCNJ11;TOMM34;PACRG;APAF1;GPR37
protein bindingPRPF8;TMEM43;MSR1;FARSA;ARNTL1A;FIGNL1;KLK6;NBN;CCDC85B
protein binding involved in protein foldingHSPA1A;DNAJB8;RIC3;PFDN1;CALR;CLGN;CALR3;HSPA1B;PDCL3
receptor bindingMIF;HCST;ACOT2;AGRP2;DAO1;ACOT8;ACOX3;CADM2A;JAK2
ubiquitin protein ligase bindingGABARAPL1;RBX1;UBE2Z;GPR19;CD40;HIF1A;TRAF4;FANCL;STUB1
unfolded protein bindingERO1LB;CLPXA;DNAJB5;HSPA8;TMEM67;DNAJA3A;HSP26;PPIA;AIPL1
virus receptor activityPVR;ICAM1;ANPEP;SIVA1;PVRL1;LDLR;DPP4;ITGB1;DAG1

HSPA1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA1B.

EGFR; STUB1; SNCA; HSP90AA1

Negroni, L; Taouji, S; et al. Integrative Quantitative Proteomics Unveils Proteostasis Imbalance in Human Hepatocellular Carcinoma Developed on Nonfibrotic Livers. MOLECULAR & CELLULAR PROTEOMICS 13:3473-3483(2014).
Lenna, S; Townsend, DM; et al. HLA-B35 Upregulates Endothelin-1 and Downregulates Endothelial Nitric Oxide Synthase via Endoplasmic Reticulum Stress Response in Endothelial Cells. JOURNAL OF IMMUNOLOGY 184:4654-4661(2010).
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