IAPP
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Official Full Name
Islet amyloid polypeptide
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Overview
Amylin, or Islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone. It is cosecreted with insulin from the pancreatic β-cells in the ratio of approximately 100:1. Amylin plays a role in glycemic regulation by slowing gastric emptying and promoting satiety, thereby preventing post-prandial spikes in blood glucose levels. IAPP is processed from an 89-residue coding sequence. Proislet Amyloid Polypeptide (proIAPP,Proamylin, Amyloid Polypeptide Precursor, Proislet Protein) is produced in the pancreatic beta cells (β-cells) as a 67 amino acid, 7404 Dalton pro-peptide and undergoes post-translational modifications including protease cleavage to produce amylin. -
Synonyms
DAP; IAP; Islet amyloid polypeptide (diabetes-associated peptide; amylin); amylin; diabetes-associated peptide; insulinoma amyloid peptide; IAPP;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Synthetic
- Yeast
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- IAPP Related Articles
IAPP involved in several pathways and played different roles in them. We selected most pathways IAPP participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with IAPP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Maturity onset diabetes of the young | INS2;FOXA3;BHLHA15;IAPP;HNF1B;PAX4;NEUROG3;NR5A2;HNF4A |
IAPP has several biochemical functions, for example, hormone activity, identical protein binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IAPP itself. We selected most functions IAPP had, and list some proteins which have the same functions with IAPP. You can find most of the proteins on our site.
Function | Related Protein |
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hormone activity | IFNT2;INSL5;ADCYAP1A;INSL5A;FAM132A;CRH;GAST;SST3;GCG |
identical protein binding | GOT1;UBE4A;HACL1;HSP90AA1;KCTD17;P2RX2;NDC80;ALDOB;STXBP1 |
receptor binding | NRG2B;PLA2G1B;PVRL1;MLYCD;PLAT;HSPA1B;NUDT19;WNT7AA;NTF3 |
IAPP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IAPP here. Most of them are supplied by our site. Hope this information will be useful for your research of IAPP.
- Q&As
- Reviews
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Ask a questionCustomer Reviews (3)
Write a reviewIn addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.
The manufacturer's supply management capabilities assure a seamless and continuous provision of the IAPP protein.
With their meticulous documentation and support, I am confident that my utilization of IAPP protein in clinical trials will meet all necessary regulations and guidelines.
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