IARS
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Official Full Name
isoleucyl-tRNA synthetase
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Overview
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5 UTRs. -
Synonyms
IARS; isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic; IARS1; ILRS; isoleucine tRNA ligase 1; cytoplasmic; FLJ20736; IleRS; IRS; Isoleucine tRNA ligase; Isoleucine tRNA synthetase; Isoleucyl tRNA synthetase; PRO0785; OTTHUMP00000021636; isoleucine--tRNA ligase; isoleucine tRNA ligase 1, cytoplasmic;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- Myc
- His|T7
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | IARS-8217H | Recombinant Human IARS protein, His & T7-tagged | E.coli | His/T7 | Met1~Arg500 (Accession # P41252) |
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| Human | IARS-5318HCL | Recombinant Human IARS 293 Cell Lysate | HEK293 | N/A |
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| Human | IARS-4313H | Recombinant Human IARS protein, His&Myc-tagged | E.coli | His&Myc | 693-852aa |
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| Human | IARS-2929H | Recombinant Human IARS protein, His-tagged | E.coli | His | 707-1055 aa | |
| Mouse | IARS-7964M | Recombinant Mouse IARS Protein | Mammalian Cell | His |
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| Mouse | IARS-4398M-B | Recombinant Mouse IARS Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | IARS-4398M | Recombinant Mouse IARS Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Zebrafish | IARS-10267Z | Recombinant Zebrafish IARS | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- IARS Related Articles
IARS involved in several pathways and played different roles in them. We selected most pathways IARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aminoacyl-tRNA biosynthesis | YARS2;MTFMT;RARS;HARS2;PSTK;QARS;HARS;SARS;AARS2 |
IARS has several biochemical functions, for example, ATP binding, GTPase binding, aminoacyl-tRNA editing activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IARS itself. We selected most functions IARS had, and list some proteins which have the same functions with IARS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TAP1;MYO3A;UCKL1;PRKAA1;ERCC3;NLRP9B;DGKQ;DDX10;CAMK1DA |
| GTPase binding | GNB2;SPTBN1;YBX1;MARCH5;RASA1;SH3GL1;GNB3;GOLGA4;HSP90AA1 |
| aminoacyl-tRNA editing activity | IARS;AARS;VARS2;VARS;IARS2;LARS;DTD1;DTD2;LARS2 |
| isoleucine-tRNA ligase activity | IARS2;IARS |
| protein binding | GRAMD3;CETN3;MAP3K3;ATPAF1;ASS1;THBD;PELI3;ATP1A1;TOMM22 |
IARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IARS here. Most of them are supplied by our site. Hope this information will be useful for your research of IARS.
EPRS; gag; NFKB2; NFKBIE; MAP3K7; YWHAZ; NFKB2; NFKBIB; TANK; MAP3K14; MAP3K3; IKBKG; ERBB2; 15-deoxy-delta(12,14
- Q&As
- Reviews
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