iars
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  • Official Full Name
  • isoleucyl-tRNA synthetase
  • Background
  • Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5 UTRs.
  • Synonyms
  • IARS; isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic; IARS1; ILRS; isoleucine tRNA ligase 1; cytoplasmic; FLJ20736; IleRS; IRS; Isoleucine tRNA ligase; Isoleucine tRNA synthetase; Isoleucyl tRNA synthetase; PRO0785; OTTHUMP00000021636; isoleucine--tRNA ligase; isoleucine tRNA ligase 1, cytoplasmic
Cat.#:IARS-8217HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IARS protein, His & T7-tagged
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Cat.#:IARS-7964MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IARS Protein
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Cat.#:IARS-10267ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IARS
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Cat.#:IARS-5318HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IARS 293 Cell Lysate
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Involved Pathway

IARS involved in several pathways and played different roles in them. We selected most pathways IARS participated on our site, such as Aminoacyl-tRNA biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IARS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Aminoacyl-tRNA biosynthesis
YARS; TARS2; QRSL1; RARS2; RARS; MADD; HARS2; KARS; WARS; DARS

Protein Function

IARS has several biochemical functions, for example, ATP binding, GTPase binding, aminoacyl-tRNA editing activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IARS itself. We selected most functions IARS had, and list some proteins which have the same functions with IARS. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NRBP1; PLK1; SIK3; ROR2; DCAMKL2; DCLK3; GRK5; DHX34; NUBPL; CUL9
Function GTPase binding
Related Protein AIMP1; STOML2; RASA1; SH3GL1; VPS41; HSP90AA1; ENO1; GOLGA4; GM5506; IARS
Function aminoacyl-tRNA editing activity
Related Protein LARS2; VARS; PRORSD1; IARS; VARS2; DTD2; LARS; IARS2; AARS; DTD1
Function isoleucine-tRNA ligase activity
Related Protein IARS2; IARS
Function protein binding
Related Protein NLGN3; HNRPDL; TUBA1A; CD6; ROCK1; TNFRSF1A; RCAN1; CNEP1R1; NRL; MRPL40

Interacting Protein

IARS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IARS here. Most of them are supplied by our site. Hope this information will be useful for your research of IARS.
EPRS; gag; NFKB2; NFKBIE; MAP3K7; YWHAZ; NFKB2; NFKBIB; TANK; MAP3K14; MAP3K3; IKBKG; ERBB2; 15-deoxy-delta(12,14

IARS Related Articles

Smid, BE; Hoogendijk, SL; et al. A revised home treatment algorithm for Fabry disease: Influence of antibody formation. MOLECULAR GENETICS AND METABOLISM 108:132-137(2013).
Wilcox, WR; Linthorst, GE; et al. Anti-alpha-galactosidase A antibody response to agalsidase beta treatment: Data from the Fabry Registry. MOLECULAR GENETICS AND METABOLISM 105:443-449(2012).