ick
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  • Official Full Name
  • intestinal cell (MAK-like) kinase
  • Background
  • Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
  • Synonyms
  • ICK; intestinal cell (MAK-like) kinase; serine/threonine-protein kinase ICK; KIAA0936; LCK2; MGC46090; MRK; hICK; MAK-related kinase; laryngeal cancer kinase 2; serine/threonine protein kinase; ECO
Cat.#:ICK-28676THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ICK
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Cat.#:ICK-7867HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ICK protein, His & T7-tagged
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Cat.#:Ick-7868MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ick protein, His & T7-tagged
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Cat.#:ICK-7974MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ICK Protein
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Cat.#:ICK-2980RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ICK Protein
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Cat.#:Ick-7869RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ick protein, His & T7-tagged
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Cat.#:ICK-1026HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Intestinal Cell (MAK-like) Kinase, GST-tagged
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Cat.#:ICK-833HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ICK cell lysate
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Protein Function

ICK has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICK itself. We selected most functions ICK had, and list some proteins which have the same functions with ICK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RTCD1; PKN1B; BMPR1A; EP400; YME1L1B; ACTG1; PRKX; SLC27A2; SGK1; MAP2K7
Function cyclin-dependent protein serine/threonine kinase activity
Related Protein CCND3; MAK; CDK10; CDK8; CCNK; STK30; ICK; CDK14; CDK1; CDK5R1
Function magnesium ion binding
Related Protein MAST2; SERPINB1A; COMTB; SPHK1; IDH3B; STK38L; STK38; PRPS1; DYRK3; ITPK1
Function protein binding
Related Protein CRB1; SMARCAL1; FRAS1; MED29; CARKD; METTL21C; EPM2AIP1; ARHGEF15; MAU2; HIST2H4
Function protein serine/threonine kinase activity
Related Protein DCLK2; NEK12; PRKACAB; RAF1B; AKT2; OXSR1A; TTBK2; TSSK6; KALRN; DYRK1B

Interacting Protein

ICK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICK here. Most of them are supplied by our site. Hope this information will be useful for your research of ICK.
HSP90AB1; SMAD1; TP53; MCM7; PPP2CB; CPSF1; NUP188; PSMD1

ICK Related Articles

Vincent, M; Teppaz, G; et al. Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse. MABS 6:1026-1037(2014).
Vincent, M; Bessard, A; et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. INTERNATIONAL JOURNAL OF CANCER 133:757-765(2013).