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ICK

  • Official Full Name

    intestinal cell (MAK-like) kinase

  • Overview

    Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
  • Synonyms

    ICK; intestinal cell (MAK-like) kinase; serine/threonine-protein kinase ICK; KIAA0936; LCK2; MGC46090; MRK; hICK; MAK-related kinase; laryngeal cancer kinase 2; serine/threonine protein kinase; ECO;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ICK-1026H Recombinant Human Intestinal Cell (MAK-like) Kinase, GST-tagged Sf9 Insect Cell GST
Human ICK-7867H Recombinant Human ICK protein, His & T7-tagged E.coli His/T7 Met1~Phe284 (Accession # Q9UPZ9)
Human ICK-28676TH Recombinant Human ICK Insect Cell N/A 632 amino acids
Human ICK-833HCL Recombinant Human ICK cell lysate N/A
Human ICK-9666HF Active Recombinant Full Length Human ICK Protein, GST-tagged Insect (sf21) GST 1-632
Mouse ICK-7974M Recombinant Mouse ICK Protein Mammalian Cell His
Mouse Ick-7868M Recombinant Mouse Ick protein, His & T7-tagged E.coli His/T7 Met1~Phe284 (Accession # Q9JKV2)
Mouse ICK-4404M Recombinant Mouse ICK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ICK-4404M-B Recombinant Mouse ICK Protein Pre-coupled Magnetic Beads HEK293
Rat ICK-2980R Recombinant Rat ICK Protein Mammalian Cell His
Rat Ick-7869R Recombinant Rat Ick protein, His & T7-tagged E.coli His/T7 Met1~Phe284 (Accession # Q62726)
Rat ICK-2635R Recombinant Rat ICK Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ICK-2635R-B Recombinant Rat ICK Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ICK Related Articles

ICK involved in several pathways and played different roles in them. We selected most pathways ICK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ICK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ICK has several biochemical functions, for example, ATP binding, cyclin-dependent protein serine/threonine kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ICK itself. We selected most functions ICK had, and list some proteins which have the same functions with ICK. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACTC1A;ACSL3;TNIKA;MLKL;RPS6KA2;CHKA;MYO6;CENPE;PPP1CA
cyclin-dependent protein serine/threonine kinase activityCDK14;CDK15;CDK10;CDK9;MOK;ICK;STK30;CDKL2;CDK5
magnesium ion bindingATP11C;THTPA;PKM2;GCLC;COMTB;NUAK2;CIB3;ATP8B1;ICK
protein bindingPKN3;FAM108A1;NEBL;SOX14;RPS13;KIAA0101;TXLNG;SCRN1;SRGAP2
protein serine/threonine kinase activitySMOK2B;PRKCQ;PRKCZ;ICK;HIPK1;RPS6KA3;TSSK1;PAK3;BUB1B

ICK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICK here. Most of them are supplied by our site. Hope this information will be useful for your research of ICK.

HSP90AB1; SMAD1; TP53; MCM7; PPP2CB; CPSF1; NUP188; PSMD1

Vincent, M; Teppaz, G; et al. Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse. MABS 6:1026-1037(2014).
Vincent, M; Bessard, A; et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. INTERNATIONAL JOURNAL OF CANCER 133:757-765(2013).
  • Q&As
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