id4
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  • Official Full Name
  • inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
  • Background
  • This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic;helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently,;the activity of the encoded protein depends on the protein binding partner.
  • Synonyms
  • ID4; inhibitor of DNA binding 4, dominant negative helix-loop-helix protein; DNA-binding protein inhibitor ID-4; bHLHb27; class B basic helix-loop-helix protein 27; IDB4
Cat.#:ID4-14045HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ID4, His-tagged
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Cat.#:ID4-28078THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ID4
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Cat.#:ID4-28592THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ID4
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Cat.#:ID4-7982MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ID4 Protein
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Cat.#:ID4-2189RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ID4 Protein, His-tagged
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Cat.#:ID4-5855CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ID4
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Cat.#:ID4-3700ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ID4
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Cat.#:ID4-5309HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ID4 293 Cell Lysate
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Involved Pathway

ID4 involved in several pathways and played different roles in them. We selected most pathways ID4 participated on our site, such as TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ID4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TGF-beta signaling pathway
MAPK3; AMHR2; RHOAB; NDR1; ID2A; SKP1; RPS6KB2; RHOAA; ID1; IFNG1-2
Signaling pathways regulating pluripotency of stem cells
WNT9A; WNT7A; LIF; RAF1; SMAD5; PCGF2; FGF2; WNT2; WNT11; SOX2

Protein Function

ID4 has several biochemical functions, for example, RNA polymerase II transcription factor binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ID4 itself. We selected most functions ID4 had, and list some proteins which have the same functions with ID4. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription factor binding
Related Protein GATA6; GATA4; GFI1B; GATA1A; DHX9; SPOP; TBX20; TP53; T; MIXL1
Function protein binding
Related Protein AHSP; ELF2; ANP32B; DHRS1; RALB; PPIL3; TAG-260; ITGB1; AASDHPPT; CDKN2AIP
Function protein dimerization activity
Related Protein POLR2J3; USF1L; CLOCKA; MTOR; FIGLA; AIFM1; HER5; ATOH7; PPP3CA; STAT3
Function transcription corepressor activity
Related Protein SIAH2; MXI1; CDX2; AJUBA; PROX1; POU1F1; SSX4; YAF2; SKOR2; CREG1

Interacting Protein

ID4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ID4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ID4.
SRC; NCK1; PLCG1; PIK3R1; CRK; GRB2

ID4 Related Articles

Snyder, AD; Dulin-Smith, AN; et al. Expression Pattern of Id Proteins in Medulloblastoma. PATHOLOGY & ONCOLOGY RESEARCH 19:437-446(2013).
Mohebbi, H; Rahimi, R; et al. Immunological responses to four-day of consecutive and non-consecutive circuit resistance exercise. MEDICINA DELLO SPORT 65:485-496(2012).