idh1
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  • Official Full Name
  • isocitrate dehydrogenase 1 (NADP+), soluble
  • Background
  • Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate.
  • Synonyms
  • Cytosolic NADP isocitrate dehydrogenase; Cytosolic NADP-isocitrate dehydrogenase; ICDH; IDCD; IDH; IDH1; IDHC_HUMAN; IDP; IDPC; Isocitrate dehydrogenase [NADP] cytoplasmic; Isocitrate dehydrogenase 1 (NADP+) soluble; NADP dependent isocitrate dehydrogenase cytosolic; NADP dependent isocitrate dehydrogenase peroxisomal; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; PICD; Isocitrate dehydrogenase
Cat.#:IDH1-565MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IDH1 Protein (7-407 aa), His-tagged
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Cat.#:IDH1-109HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH1(R100A) Protein, His-tagged
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Cat.#:IDH1-1284HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Isocitrate Dehydrogenase 1 (NADP+), Soluble, His-tagged
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Cat.#:IDH1-042HTag:MYC/DDK
Source (Host):HEK293 cellSpecies:Human
Product nameRecombinant Human IDH1 Protein, MYC/DDK-tagged
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Cat.#:IDH1-043HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IDH1 Protein, His-tagged
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Cat.#:IDH1-044HTag:DDK
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IDH1 Protein, DDK-tagged
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Cat.#:IDH1-1044HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH1 Protein, His-tagged
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Cat.#:IDH1-108HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH1(G97D) Protein, His-tagged
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Cat.#:IDH1-110HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH1(R100Q) Protein, His-tagged
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Cat.#:IDH1-111HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH1(R132C) Protein, His-tagged
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Cat.#:IDH1-112HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH1(R132H) Protein, His-tagged
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Cat.#:IDH1-114HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human IDH1(Y139D) Protein, His-tagged
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Cat.#:IDH1-14047HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH1, His-tagged
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Cat.#:IDH1-246HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IDH1
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Cat.#:IDH1-2527HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH1, His tagged
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Cat.#:IDH1-5849HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IDH1 protein, DDK-tagged
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Cat.#:Idh1-1583MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Idh1 protein, His & GST-tagged
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Cat.#:IDH1-7984MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IDH1 Protein
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Cat.#:Idh1-1584RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Idh1 protein, His-tagged
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Cat.#:IDH1-2985RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IDH1 Protein
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Cat.#:IDH1-2191RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IDH1 Protein, His-tagged
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Cat.#:IDH1-11544ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDH1
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Cat.#:IDH1-5307HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDH1 293 Cell Lysate
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Involved Pathway

IDH1 involved in several pathways and played different roles in them. We selected most pathways IDH1 participated on our site, such as Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Citrate cycle (TCA cycle)
SDHD; MDH1AA; SUCLG1; ACLY; IDH3G; FH; PDHA1; DLAT; OGDH; MDH1
Glutathione metabolism
GSTP2; GSTM3; GSTM6; GGT1; ANPEP; GSTP1; ANPEPB; GGT6; GSTT1; GPX5
Metabolic pathways
DCT; TPI1; SUCLG1; CYP27B1; PIGW; POLR2J; NME6; PTDSS1A; CMAS; DLDH
Carbon metabolism
GPT; TKTL1; SUCLA2; PC; GPT2L; PSPH; ALDOB; PGAM2; AGXTB; HADHA
-Oxocarboxylic acid metabolism
GOT2B; IDH2; GOT2; ACO2; IDH3G; GPT2L; GPT2; AADAT; GOT1; IDH1
Biosynthesis of amino acids
RPIA; PKMA; GAPDH; ENO3; IDH1; TPI1B; MAT2AB; PGK2; ARG2; IDH3B
Peroxisome
ANI_1_2390104; PEX11B; PMVK; DAO.3; DAO.1; DDO; NOS2; AGXTB; ABCD2; MPV17L
Central carbon metabolism in cancer
TRP53; TP53; SIRT6; SCO2; KRAS; PIK3CD; SLC7A5; PIK3R5; PIK3CA; SLC2A2

Protein Function

IDH1 has several biochemical functions, for example, NAD binding, NADP binding, isocitrate dehydrogenase (NADP+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH1 itself. We selected most functions IDH1 had, and list some proteins which have the same functions with IDH1. You can find most of the proteins on our site.
Function
Related Protein
Function NAD binding
Related Protein GAPDH; NDUFS2; HSD17B10; BDH2; LDHB; TESCA; GPD1; AOX3L1; DLD; CYB5R3
Function NADP binding
Related Protein NOS2; H6PD; NOX5; HMGCRB; FMO1; NDOR1; DPYD; G6PDX; FMO3; MTHFR
Function isocitrate dehydrogenase (NADP+) activity
Related Protein IDH1; IDH2
Function magnesium ion binding
Related Protein NIM1; COMT; PPM1NB; EYA2; PGM5; TSSK2; NLK; PCK1; ENO1A; NUDT18
Function protein homodimerization activity
Related Protein CSF1; ATPIF1A; IGJ; PEX7; STK10; NR0B2; SRGAP2A; ADIPOQ; ABCG1; PRPS2
Function receptor binding
Related Protein TNFSF12; APOF; CADM2; F7; Fert2; FZD8; CCL2; Icosl; UFD1L; INSL3

Interacting Protein

IDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH1.
gltX; mtfA; CEP57L1; ZHX1; 15-deoxy-delta(12,14; ere_dna

IDH1 Related Articles

Bunse, L; Schumacher, T; et al. Proximity ligation assay evaluates IDH1(R132H) presentation in gliomas. JOURNAL OF CLINICAL INVESTIGATION 125:593-606(2015).
Kawasoe, T; Takeshima, H; et al. Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme. JOURNAL OF NEUROSURGERY 122:317-323(2015).