idh3g
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  • Official Full Name
  • isocitrate dehydrogenase 3 (NAD+) gamma
  • Background
  • Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined.
  • Synonyms
  • IDH3G; isocitrate dehydrogenase 3 (NAD+) gamma; isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; mitochondrial; H IDHG; H-IDHG; IDH gamma; IDH3G_HUMAN; Isocitrate dehydrogenase [NAD] subunit gamma; Isocitric dehydrogenase; Isocitric dehydrogenase subunit gamma; NAD (H) specific isocitrate dehydrogenase gamma subunit; NAD(+) specific ICDH; NAD(+)-specific ICDH; NAD(+)-specific ICDH subunit gamma; NAD+ specific ICDH; OTTHUMP00000025984; OTTHUMP00000025985; OTTHUMP00000025987; OTTHUMP00000025988; OTTHUMP00000214764; IDH-gamma; NAD+-specific ICDH; NAD (H)-specific isocitrate dehydrogenase gamma subunit; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit
Cat.#:IDH3G-1324HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Isocitrate Dehydrogenase 3 (NAD+) Gamma, His-tagged
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Cat.#:IDH3G-28079THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IDH3G
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Cat.#:IDH3G-28927THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDH3G, His-tagged
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Cat.#:IDH3G-7988MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IDH3G Protein
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Cat.#:IDH3G-2471ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDH3G
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Cat.#:IDH3G-5302HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDH3G 293 Cell Lysate
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Cat.#:IDH3G-5303HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDH3G 293 Cell Lysate
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Involved Pathway

IDH3G involved in several pathways and played different roles in them. We selected most pathways IDH3G participated on our site, such as Citrate cycle (TCA cycle), Metabolic pathways, Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDH3G were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Citrate cycle (TCA cycle)
IDH3B; FH; CS; PCXB; SUCLG1; MDH2; DLAT; PC; OGDH; DLDH
Metabolic pathways
NDUFS8B; POLR2J2; ITPKB; UGT8; G6PDX; AGXT; XYLT2; ST3GAL5; QDPRB2; PNP
Carbon metabolism
PGK2; SUCLG2; GPT2L; PDHB; TKTL2; ENO1B; PGAM1B; FBP1; SUCLA2; CAT
-Oxocarboxylic acid metabolism
ACY1; GPT2L; GOT2; GPT2; GOT1; IDH2; IDH3A; AADAT; ACO2; GPT
Biosynthesis of amino acids
SDSL; RPE; ALDH7A1; PRPS1L1; pykF; PFKL; ALDOAB; GPT; GLULC; ASS1

Protein Function

IDH3G has several biochemical functions, for example, ATP binding, NAD binding, isocitrate dehydrogenase (NAD+) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDH3G itself. We selected most functions IDH3G had, and list some proteins which have the same functions with IDH3G. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ITPK1; BAZ1B; UBE2QL1; TARSL2; UCKL1A; DDX4; PRKCDA; ATP1A1B; SPS2; MTHFD1
Function NAD binding
Related Protein AOX1; AHCY; ADH4; UGDH; CTBP1; IDH2; GRHPRA; PARP1; GRHPR; HADHA
Function isocitrate dehydrogenase (NAD+) activity
Related Protein IDH3B; IDH3G; IDH3A
Function magnesium ion binding
Related Protein PKMB; DCTPP1; ADSS; CLYBL; NME1; FOXK2; THTPA; STK38; CIB3; RPS6KA6

Interacting Protein

IDH3G has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDH3G here. Most of them are supplied by our site. Hope this information will be useful for your research of IDH3G.
IDH3A; adp; MYC

IDH3G Related Articles

Bzymek, KP; Colman, RF; et al. Role of alpha-Asp(181), beta-Asp(192), and gamma-Asp(190) in the distinctive subunits of human NAD-specific isocitrate dehydrogenase. BIOCHEMISTRY 46:5391-5397(2007).
Dal Monego, S; Colitti, M; et al. Evaluation of gene expression profiles of pig skeletal muscle in response to energy content of the diets using human microarrays. ITALIAN JOURNAL OF ANIMAL SCIENCE 6:45-59(2007).