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  • Official Full Name
  • iduronate 2-sulfatase
  • Background
  • Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
  • Synonyms
  • IDS; iduronate 2-sulfatase; SIDS; Hunter syndrome; AW214631; Alpha L iduronate sulfate sulfatase; Alpha-L-iduronate sulfate sulfatase; IDS_HUMAN; Iduronate 2 sulfatase 14 kDa chain; Iduronate 2 sulfatase 42 kDa chain; Iduronate 2 sulfatase; Iduronate 2-sulfatase 14 kDa chain; Iduronate sulfatase; Idursulfase; MPS2; RP23-29M4.1; iduronate 2-sulfatase 42 kDa chain
Cat.#:IDS-993HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IDS Protein, MYC/DDK-tagged
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Cat.#:Ids-1974MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Iduronate 2-Sulfatase, His-tagged
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Cat.#:IDS-1580HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDS protein, His-tagged
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Cat.#:IDS-211HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IDS Protein, His-tagged
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Cat.#:Ids-1581MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ids protein, His-tagged
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Cat.#:Ids-640MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Ids Protein, His-tagged
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Cat.#:IDS-7994MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IDS Protein
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Cat.#:Ids-1582RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ids protein, His & GST-tagged
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Cat.#:IDS-5038CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IDS
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Cat.#:IDS-5003ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDS
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Cat.#:IDS-2934HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IDS cell lysate
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Cat.#:IDS-P037HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IDS therapeutic protein
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Involved Pathway

IDS involved in several pathways and played different roles in them. We selected most pathways IDS participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan degradation
GNSA; HPSE2; HYAL1; NAGLU; GLB1; IDS; IDUA; ARSB; GNSB; HPSE
Metabolic pathways
CYP2C55; CPOX; NADK2; B3GNT3; MTHFD1B; DSE; AKR1C3; ALOX12E; LDHA; GLCEB
Lysosome
LAPTM4B; ATP6V0B; ASAH1B; AP4E1; ACP5; LAPTM5; CTSSB.1; SMPD1; PLA2G15; Ctsl

Protein Function

IDS has several biochemical functions, for example, iduronate-2-sulfatase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDS itself. We selected most functions IDS had, and list some proteins which have the same functions with IDS. You can find most of the proteins on our site.
Function
Related Protein
Function iduronate-2-sulfatase activity
Related Protein IDS
Function metal ion binding
Related Protein VPS29; SKINT8; PDLIM3A; MGRN1A; TRIM46B; HEPHL1; ZFP146; NR1D4A; HRG; ZSCAN21

Interacting Protein

IDS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDS here. Most of them are supplied by our site. Hope this information will be useful for your research of IDS.
Dlg4; FOS; midostaurin

IDS Related Articles

Andersson, B; Swolin-Eide, D; et al. Short-term changes in bone formation markers following growth hormone (GH) treatment in short prepubertal children with a broad range of GH secretion. CLINICAL ENDOCRINOLOGY 82:91-99(2015).
Boado, RJ; Hui, EKW; et al. Insulin Receptor Antibody-Iduronate 2-Sulfatase Fusion Protein: Pharmacokinetics, Anti-Drug Antibody, and Safety Pharmacology in Rhesus Monkeys. BIOTECHNOLOGY AND BIOENGINEERING 111:2317-2325(2014).