idua
Share
  • Official Full Name
  • iduronidase, alpha-L-
  • Background
  • This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I).
  • Synonyms
  • IDUA; iduronidase, alpha-L-; alpha-L-iduronidase; MPS1; Alpha L iduronidase; IDA; Iduronidase alpha L
Cat.#:IDUA-196HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human IDUA Protein, His-tagged
+Inquiry
Cat.#:IDUA-1421HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IDUA Protein (28-653 aa), His-tagged
+Inquiry
Cat.#:IDUA-569HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDUA Protein (28-653 aa), His-tagged
+Inquiry
Cat.#:IDUA-995HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IDUA Protein, MYC/DDK-tagged
+Inquiry
Cat.#:IDUA-27HTag:
Source (Host):NS0Species:Human
Product nameRecombinant Human IDUA, His-tagged
+Inquiry
Cat.#:IDUA-1579HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDUA protein, His & T7-tagged
+Inquiry
Cat.#:Idua-220MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Idua protein, His-tagged
+Inquiry
Cat.#:Idua-3369MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Idua, His-tagged
+Inquiry
Cat.#:IDUA-3082CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IDUA
+Inquiry
Cat.#:IDUA-P025HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IDUA therapeutic protein
+Inquiry

Involved Pathway

IDUA involved in several pathways and played different roles in them. We selected most pathways IDUA participated on our site, such as Glycosaminoglycan degradation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDUA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycosaminoglycan degradation
HPSE2; GNSA; SGSH; IDUA; HYAL6; HEXA; GNS; ARSB; HEXB; NAGLU
Metabolic pathways
PNAT10; DEGS1; OXSR1; NMRK1; ALDH1A2; HSD17B12A; FUT9A; PLCB4; GALM; B3GNT2
Lysosome
CTSG; IDUA; ACP2; GUSB; AP1G2; AP4E1; CTSSB.2; ATP6V0A2; ATP6V0A4; Abca2

Protein Function

IDUA has several biochemical functions, for example, L-iduronidase activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IDUA itself. We selected most functions IDUA had, and list some proteins which have the same functions with IDUA. You can find most of the proteins on our site.
Function
Related Protein
Function L-iduronidase activity
Related Protein IDUA
Function receptor binding
Related Protein PVRL2L; MBL2; CROT; FASLG; CCL15; SNX17; RARA; MLYCD; MAP7; C3

Interacting Protein

IDUA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDUA here. Most of them are supplied by our site. Hope this information will be useful for your research of IDUA.
MPP3

IDUA Related Articles

Pasqualim, G; Baldo, G; et al. Effects of Enzyme Replacement Therapy Started Late in a Murine Model of Mucopolysaccharidosis Type I. PLOS ONE 10:-(2015).
Hinderer, C; Bell, P; et al. Intrathecal Gene Therapy Corrects CNS Pathology in a Feline Model of Mucopolysaccharidosis I. MOLECULAR THERAPY 22:2018-2027(2014).