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IFT122

Official Full Name

intraflagellar transport 122 homolog (Chlamydomonas)
Overview

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms

IFT122; intraflagellar transport 122 homolog (Chlamydomonas); WD repeat domain 10 , WDR10; intraflagellar transport protein 122 homolog; SPG; WDR10p; WDR140; CED; WD repeat domain 10; WDR10; WD repeat-containing protein 10; WD repeat-containing protein 140;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IFT122-14088H	Recombinant Human IFT122, His-tagged	E.coli	His	1-359a.a.	$319 / 25ug
Human	IFT122-5276HCL	Recombinant Human IFT122 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	IFT122-8047M	Recombinant Mouse IFT122 Protein	Mammalian Cell	His		Inquiry
Mouse	IFT122-4448M	Recombinant Mouse IFT122 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	IFT122-4448M-B	Recombinant Mouse IFT122 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	IFT122-12147Z	Recombinant Zebrafish IFT122	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
IFT122 Related Articles

IFT122 involved in several pathways and played different roles in them. We selected most pathways IFT122 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT122 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	BBS13;CEP164;IFT172;CKAP5;TTC8;NEK2;CNGA2;PCM1;FLR
Hedgehog off state	IFT122;IFT88;TTC21B;KIF7;BBS13;OFD1;KIF3A;TULP3;IFT172
Intraflagellar transport	TTC30A;TNPO1;WDR19;TRAF3IP1;TTC30A1;KIFAP3;TCTEX1D1;TCTEX1D2;DYNLRB1
Organelle biogenesis and maintenance	PKD2;CEP89;MRPL39;DYF-1;SCLT1;GABPA;MRPL42;BBS10;MTFMT
Signal Transduction	PDK2B;CDC42EP3;FSTB;GAS8;IFT122;PTH;ARHGAP29;OR4D2;RGS17
Signaling by Hedgehog	CDON;NOTUM1A;IFT122;RPGRIP1L;GPR161;TTC21B;IFT52;HHAT;EFCAB7

IFT122 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT122 itself. We selected most functions IFT122 had, and list some proteins which have the same functions with IFT122. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PARP9;CGGBP1;RFWD3;HSF2;ZNF335;CENPW;SIGLEC8;PRIMPOL;CARD8

IFT122 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT122 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT122.

ORF; b4dyc6_human; NUDCD3; NUDC; gatA

Behal, RH; Miller, MS; et al. Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 287:11689-11703(2012).