ift122
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  • Official Full Name
  • intraflagellar transport 122 homolog (Chlamydomonas)
  • Background
  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms
  • IFT122; intraflagellar transport 122 homolog (Chlamydomonas); WD repeat domain 10 , WDR10; intraflagellar transport protein 122 homolog; SPG; WDR10p; WDR140; CED; WD repeat domain 10; WDR10; WD repeat-containing protein 10; WD repeat-containing protein 140
Cat.#:IFT122-14088HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFT122, His-tagged
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Cat.#:IFT122-8047MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IFT122 Protein
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Cat.#:IFT122-12147ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IFT122
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Cat.#:IFT122-5276HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IFT122 293 Cell Lysate
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Involved Pathway

IFT122 involved in several pathways and played different roles in them. We selected most pathways IFT122 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT122 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of the primary cilium
CENPJ; IFT122; HSPB11; CSNK1D; WDR19; CEP290; DYNLL2; DYNLRB1; TMEM67; CEP89
Hedgehog off state
IFT122; IFT52; BBS13; IFT172; TULP3; RPGRIP1L; TTC21B; OFD1; KIF3A; KIF7
Intraflagellar transport
IFT172; TTC30A; TTC21B; KIF3B; IFT81; TCTEX1D1; WDR34; KIFAP3A; HSPB11; KIF17
Organelle biogenesis and maintenance
MRPL42; MRPS34; C10orf2; MRPS30; C11orf60; TTC21B; IFT52; TTC26; TMEM67; TFB2M
Signal Transduction
TAC3; SH2B3; UTS2; VIP2; OXER1; CDC73; FOXH1; ABHD12; OPN5; RGS1
Signaling by Hedgehog
NOTUM1A; IFT88; GAS8; EVC2; WDR35; INTU; EFCAB7; SPOPL; BBS13; TULP3

Protein Function

IFT122 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT122 itself. We selected most functions IFT122 had, and list some proteins which have the same functions with IFT122. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein MYLK2; BAAT; QKI; PEX11A; BCL2; MYC; C18orf56; CHAC1; DPF2; SLC22A5

Interacting Protein

IFT122 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT122 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT122.
ORF; b4dyc6_human; NUDCD3; NUDC; gatA

IFT122 Related Articles

Behal, RH; Miller, MS; et al. Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 287:11689-11703(2012).