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IFT88

Official Full Name

intraflagellar transport 88 homolog (Chlamydomonas)
Overview

This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.
Synonyms

IFT88; intraflagellar transport 88 homolog (Chlamydomonas); tetratricopeptide repeat domain 10 , TTC10; intraflagellar transport protein 88 homolog; D13S1056E; hTg737; MGC26259; polaris homolog; Tg737; TPR repeat protein 10; tetratricopeptide repeat domai;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	IFT88-14096H	Recombinant Human IFT88, GST-tagged	E.coli	GST	C-term-302a.a.	$319 / 25ug
Human	IFT88-5271HCL	Recombinant Human IFT88 293 Cell Lysate	HEK293	N/A		Inquiry
Human	IFT88-5270HCL	Recombinant Human IFT88 293 Cell Lysate	HEK293	N/A		Inquiry
Zebrafish	IFT88-222Z	Recombinant Zebrafish IFT88	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

IFT88 involved in several pathways and played different roles in them. We selected most pathways IFT88 participated on our site, such as Assembly of the primary cilium, Endochondral Ossification, Hedgehog off state, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	TMEM216;IQCB1;RABL5;IFT122;PLK4;ARL13B;MAPRE1B;TUBB4B;CYS1
Endochondral Ossification	ADAMTS1;MGP;SOX9A;KIF3A;SERPINH1;MMP13;COL10A1;RUNX3;PTHLH
Hedgehog off state	WDR35;IFT52;GPR161;IFT172;KIF3A;BBS13;IFT88;MKS1;KIF7
Hedgehog signaling events mediated by Gli proteins	SAP30;MTSS1;CSNK1G2;IFT88;SAP18;LGALS3;CSNK1G3;SPOP;SIN3B
Intraflagellar transport	TTC21B;OST4;KIFAP3B;C11orf60;TCTEX1D1;IFT88;CLUAP1;TTC30A;IFT43
Organelle biogenesis and maintenance	TSFM;IFT52;MTRF1L;MRPL28;MARK4;CYS1;TCTEX1D2;CEP89;LZTFL1
Signal Transduction	ARHGAP26;NPS;SOX4A;TAX1BP1;RNF41;SCT;APOA4B.2;LRP10;SKILB
Signaling by Hedgehog	SCUBE2;IFT52;HHAT;WDR19;SPOP;BOC;RPGRIP1L;DISP2;WDR35

IFT88 has several biochemical functions, for example, kinesin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT88 itself. We selected most functions IFT88 had, and list some proteins which have the same functions with IFT88. You can find most of the proteins on our site.

Function	Related Protein
kinesin binding	PRC1;ATCAY;JIP1;ARPC2;SERPINB1A;PLEKHM2;MAPK8IP2;FAM83D;KIF18B
protein binding	ATXN7L3;FOXP4;PAM16;ARHGEF40;CLCNKB;CDC7;THEG;TTBK2;LNPEP

IFT88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT88 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT88.

SMNDC1; PRRC2A; q99ib8-pro_0000045602