ikbkap
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  • Official Full Name
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
  • Background
  • IKAP was initially identified as a scaffold protein of the IkappaB kinase complex that could bind to IKKa, IKK?, NF-kappaB, and the NF-kappaB-inducing kinase (NIK), although later evidence has cast doubt on this. More recent reports show that mutations in IKAP such as a frameshift leading to a truncated protein or a missense mutation that leads to defective phosphorylation are responsible for the autosomal recessive genetic disease familial dysautonomia (FD). Reports indicating that it forms part of the RNA polymerase II transcription elongation complex suggest that this disease may be due to compromised transcription elongation.
  • Synonyms
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein; IKBKAP; FD; DYS; ELP1; IKAP; IKI3; TOT1; FLJ12497; DKFZp781H1425; elongator complex protein 1; p150; OTTHUMP00000021869; IKK complex-associated protein; ikappaB kinase complex-associated protein
Cat.#:IKBKAP-497HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKBKAP Protein, MYC/DDK-tagged
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Cat.#:IKBKAP-8100MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IKBKAP Protein
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Cat.#:IKBKAP-3021RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IKBKAP Protein
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Involved Pathway

IKBKAP involved in several pathways and played different roles in them. We selected most pathways IKBKAP participated on our site, such as IL-1 Signaling Pathway, TNF-alpha NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
IL-1 Signaling Pathway
IKBKAP; IL1RN; SIRPA
TNF-alpha NF-kB Signaling Pathway
TRAF4A; TRPC4APA; ZFAND5A; SMARCB1A; SMARCC1; IKBKAP; CASP8AP2; SMARCA4A; NLRP4E; CAPN3A

Protein Function

IKBKAP has several biochemical functions, for example, ATP binding, contributes_to RNA polymerase II core binding, phosphorylase kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKAP itself. We selected most functions IKBKAP had, and list some proteins which have the same functions with IKBKAP. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PKZ; RIPK1L; ATAD1B; MAP3K5; PIK3CG; ABCB1A; SPHK1; TTLL6; GSK3AB; WNK2
Function contributes_to RNA polymerase II core binding
Related Protein ELP2; ELP3; ELP4; IKBKAP
Function phosphorylase kinase regulator activity
Related Protein ELP3; PRKAG2; IKBKAP; ELP4
Function protein kinase activity
Related Protein GM4922; RPS6KA5; EPHB4A; PRKAA1; MAPK12B; FYNA; CDK5; PKN2; GSG2; STK17B

Interacting Protein

IKBKAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKAP.
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