IKZF3
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Official Full Name
IKAROS family zinc finger 3 (Aiolos)
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Overview
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012] -
Synonyms
IKZF3; IKAROS family zinc finger 3 (Aiolos); AIO; AIOLOS; ZNFN1A3; zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- MYC
- His
- His (Fc)
- Avi
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
IKZF3 involved in several pathways and played different roles in them. We selected most pathways IKZF3 participated on our site, such as IL2-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL2-mediated signaling events | CISH;DOK2;STAM2;IKZF3 |
IKZF3 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF3 itself. We selected most functions IKZF3 had, and list some proteins which have the same functions with IKZF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | ETV5;PHOX2A;PCGF6;DBP;HMX3;KAT2B;CDX1A;ZNF79;LYL1 |
| metal ion binding | ASAP2A;CYP2B19;DNAJC21;FRAS1;RXRBB;SCRT1;ATP2A2A;ITGA4;CYP3A25 |
| protein binding | TAF8;CLNK;TOM1;ZNF664-FAM101A;IYD;NAA50;THBS1;SMAD7;SOCS3 |
| protein heterodimerization activity | HIST1H2BN;MYH7;AXL;MCL1A;P4HB;CHUK;TBX18;HIST1H4K;TGFB1 |
| protein homodimerization activity | TAP1;CLN6;SMAGP;CEBPB;TFAP4;ROPN1B;BAXB;PVR;SLC16A1 |
| sequence-specific DNA binding | GRHL2A;HOXD13A;SP5;ZBTB4;DBPA;IRX4;ETV5B;NR6A1;DRGX |
| transcription factor activity, sequence-specific DNA binding | FOXP4;PLAGL2;ZFP37;ZFP287;IRF1A;PHTF1;ZNF8;MTA1;FOXG1D |
| transcription regulatory region DNA binding | ZNF567;FOXA1;Ar;TCF7L1B;CARM1;ZNF613;NKX3-1;SALL3;TBP |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | EP300;RFX6;GATA4;DLX2;FOXF2;CEBPA;BARX1;RXRB;GATA1 |
IKZF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF3.
PRKAB2; CDKN2D; ATPAF2; TEKT4; MAGOHB
- Q&As
- Reviews
Q&As (5)
Ask a questionSeveral clinical trials are exploring the potential of targeting IKZF3 protein in the treatment of autoimmune diseases and cancer, with the aim of developing novel therapeutic strategies.
IKZF3 protein regulates the proliferation and survival of cancer cells, and its dysregulation has been associated with the development of various types of cancer.
IKZF3 protein interacts with various cellular pathways involved in immune regulation, cell proliferation, and apoptosis, making it a potential target for therapeutic interventions.
Genetic variations in the IKZF3 gene have been linked to susceptibility to autoimmune diseases and may impact clinical outcomes in patients with these conditions.
Research has suggested that IKZF3 protein expression levels may have prognostic value in certain types of cancer, and further studies are needed to validate its clinical significance.
Customer Reviews (3)
Write a reviewWith its high purity and bioactivity, IKZF3 protein ensures reliable and consistent results in a wide range of experimental applications.
the IKZF3 protein is carefully characterized, and its functional properties are well-documented.
The IKZF3 protein is of exceptional quality and is perfectly suited to meet the experimental needs of researchers.
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