ikzf3
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  • Official Full Name
  • IKAROS family zinc finger 3 (Aiolos)
  • Background
  • This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
  • Synonyms
  • IKZF3; IKAROS family zinc finger 3 (Aiolos); AIO; AIOLOS; ZNFN1A3; zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos);
Cat.#:IKZF3-487HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IKZF3 Protein, MYC/DDK-tagged
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Cat.#:IKZF3-14138HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IKZF3, His-tagged
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Cat.#:IKZF3-8106MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IKZF3 Protein
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Cat.#:IKZF3-6383CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IKZF3
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Cat.#:IKZF3-5251HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IKZF3 293 Cell Lysate
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Involved Pathway

IKZF3 involved in several pathways and played different roles in them. We selected most pathways IKZF3 participated on our site, such as IL2-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKZF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
IL2-mediated signaling events
STAM2; DOK2; IKZF3; CISH

Protein Function

IKZF3 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKZF3 itself. We selected most functions IKZF3 had, and list some proteins which have the same functions with IKZF3. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein STAT4; CDX1A; ATF4B1; ALX4; ZGLP1; ZIK1; HOXD9; GLIS1; TAL2; PAX9
Function metal ion binding
Related Protein MYLIPB; ERI3; PHLPP1; ZFP42; CYB5R4; CMAH; ZFY1; FGD2; PDLIM3B; HGS
Function protein binding
Related Protein ADAMTS3; PTPRC; NPDC1; FUS; CHMP1B; CASP14; TRMT61B; HTR1B; SNTB1; EFNA1
Function protein heterodimerization activity
Related Protein PHC2B; H2AFB1; TPD52L2; GTF2A2; PRMT5; IRAK2; BTBD11; SIM1; ADRA2A; PAFAH1B2
Function protein homodimerization activity
Related Protein TFRC; ACTN1; ANXA9; CALCOCO2; PRDX4; DPYD; TRIM9; TPD52; ASNSD1; ENPP1
Function sequence-specific DNA binding
Related Protein HOXA4A; ZNF323; HOXA4; HOXA10B; HOXD12A; ARXA; HOXC6B; DLX3; IKZF1; NKX1.2LB
Function transcription factor activity, sequence-specific DNA binding
Related Protein STAT1B; PPARA; CDX2; HOXC6B; ZFP12; TCF25; RUNX1T1; TCF3A; ZNF71; POU3F2B
Function transcription regulatory region DNA binding
Related Protein TCF7L1B; KLF1; THRA; YAP1; BCOR; GFI1; PHB; JUND; TFAP4; NR5A2
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein RXRB; OSR2; MYOCD; MAFF; GATA1; TRPS1; CREBBP; PPARG; PKNOX1; GATA2A

Interacting Protein

IKZF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKZF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of IKZF3.
PRKAB2; CDKN2D; ATPAF2; TEKT4; MAGOHB