IMPDH1
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Official Full Name
IMP (inosine 5-monophosphate) dehydrogenase 1
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Overview
The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] -
Synonyms
IMPDH1; IMP (inosine 5-monophosphate) dehydrogenase 1; IMPD; RP10; IMPD1; LCA11; sWSS2608; inosine-5-monophosphate dehydrogenase 1; IMPD 1; IMPDH 1; IMPDH-I; IMP dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Sf21 insect cells
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
IMPDH1 involved in several pathways and played different roles in them. We selected most pathways IMPDH1 participated on our site, such as Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with IMPDH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Purine metabolism | POLE4;POLE;Adcy4;POLA2;ADSS;NPR1;PRPS1B;AK7B;TWISTNB |
Drug metabolism - other enzymes | UCK2A;IMPDH1A;DPYS;IMPDH1;UGT1A3;TPMT.1;CES1C;UGT1A6;DPYDB |
Metabolic pathways | GCNT3;CMASA;B4GALT7;ADK;MSMO1;GCDH;PLCZ1;POLR2B;PLA2G12A |
IMPDH1 has several biochemical functions, for example, DNA binding, IMP dehydrogenase activity, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IMPDH1 itself. We selected most functions IMPDH1 had, and list some proteins which have the same functions with IMPDH1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ASXL2;ZBTB7A;NFYA;HIST1H2A9;ZNF789;FOXC1B;NFE2L2;GM14478;CHST13 |
IMP dehydrogenase activity | IMPDH1A;IMPDH1B;IMPDH2;IMPDH1 |
RNA binding | WDHD1;IFIT10;TTC6;THUMPD3;IFIT1;HNRNPAB;DDX11;NR0B1;HNRPK |
metal ion binding | ITPK1A;MUS81;ZBTB2A;ZNF606;UQCRC2A;JADE3;MAP3K15;TGM2A;ZFP768 |
nucleic acid binding | ZNF45L;ZFP385C;AEN;ZNRD1;ZBTB46;BHLHE22;MARF1;SETD1BA;SFRS3B |
IMPDH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IMPDH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IMPDH1.
GMNN; q7cfv5_yerpe; HTRA1; MYO1C; SEC16A; XRCC3; Junb; Lgals3bp; EMC2; Rpl35; MMGT1
- Q&As
- Reviews
Q&As (6)
Ask a questionIt is expressed in a wide range of tissues and organs, including liver, kidney, heart, muscle and immune system, among others.
This is involved in the regulation of purine metabolism in immune cells, affecting T cell activation and immune cell function.
It is highly expressed in tumor cells. It is involved in the regulation of purine metabolism and nucleic acid synthesis, and plays an important role in cell proliferation and survival.
IMPDH1 mutations may be associated with some drug resistance, because IMPDH1 is a key enzyme in purine nucleotide synthesis and plays an important role in drug treatment.
The interacts with molecules such as mTOR signaling pathway, GTpase-activating proteins and uric acid.
Mutations in IMPDH1 can cause genetic diseases such as carnivorous syphilis, immune-related diseases and neurological disorders.
Customer Reviews (3)
Write a reviewThe operation method is very simple, and accurate experimental results can be obtained easily.
Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.
High sensitivity, small amount can successfully complete the experiment.
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