INCENP
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Official Full Name
inner centromere protein antigens 135/155kDa
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Overview
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding;centromere proteins and passenger, or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive;proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM;117142). The term passenger proteins encompasses a broad collection of proteins that localize to the centromere;during specific stages of the cell cycle (Earnshaw and Mackay, 1994 (PubMed 8088460)). These include CENPE (MIM;117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and;CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 (PubMed 1860899)), the;initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of;mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During;telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after;cytokinesis (Cutts et al., 1999 (PubMed 10369859)). -
Synonyms
INCENP; inner centromere protein antigens 135/155kDa; inner centromere protein antigens (135kD, 155kD); inner centromere protein; FLJ31633; chromosomal passenger protein; inner centromere protein INCENP; binds and activates aurora-B and -C in vivo and in;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | INCENP-7037H | Recombinant Human INCENP, His-tagged | Sf9 Insect Cell | His | 783 aa-end | |
Mouse | INCENP-8205M | Recombinant Mouse INCENP Protein | Mammalian Cell | His | ||
Mouse | INCENP-4541M | Recombinant Mouse INCENP Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | INCENP-4541M-B | Recombinant Mouse INCENP Protein Pre-coupled Magnetic Beads | HEK293 | |||
Chicken | INCENP-6882C | Recombinant Chicken INCENP | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- INCENP Related Articles
INCENP involved in several pathways and played different roles in them. We selected most pathways INCENP participated on our site, such as Aurora B signaling, Aurora C signaling, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with INCENP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Aurora B signaling | NDC80;SMC4;CENPA;PEBP1;SGOL1;CBX5;CDCA8;KIF2C;KIF20A |
Aurora C signaling | AURKC;AURKB;INCENP |
Cell Cycle | CDCA5;SMAD2;ANAPC7;NIPBLB;TP53;NDEL1;TGFB2;SMAD3A;SYCE1 |
Cell Cycle, Mitotic | KIF2C;NCAPG2;LIN9;CENPP;ENSA;NCAPH2;TUBGCP2;PDS5B;NIPBLA |
M Phase | SPDL1;CDCA8;NIPBLB;TMEM188;MAU2;VRK1;NSL1;RANGAP1B;SGOL2 |
Mitotic Anaphase | SGOL2;CENPH;SKA1;AHCTF1;PDS5B;CCDC99;NDEL1A;CENPQ;SGOL1 |
Mitotic Metaphase and Anaphase | MLF1IP;ANKLE2;AHCTF1;CENPE;WAPAL;CENPI;TMPO;SGOL1;MIS12 |
Mitotic Prometaphase | WAPAL;PMF1;PANE1;CENPK;CENPO;CENPQ;ZWINT;CCDC99;NDC80 |
INCENP has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INCENP itself. We selected most functions INCENP had, and list some proteins which have the same functions with INCENP. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | MAP3K8;JAKMIP2;TAF6L;YWHAG;TBC1D1;SIRT3;PDGFA;SDC1;EML1 |
INCENP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INCENP here. Most of them are supplied by our site. Hope this information will be useful for your research of INCENP.
BIRC5; AURKB; CBX5
- Q&As
- Reviews
Q&As (6)
Ask a questionThe protein to participate in the nucleus division and dynamic correction, can be used for genetic research, oncology research, stem cell technology and drug screening, and other fields.
INCENP proteins are important components of mitotic regulatory proteins, which are involved in the regulation and control of various stages during mitosis. Studies have shown that INCENP plays an inhibitory role in the early stage of cancer and is involved in the formation and progression of tumors.
The important regulatory region of INCENP protein is located in its N-terminus, which is directly involved in the regulation and control of mitosis.
The mainly involved in regulating mitosis, but some studies show that INCENP may also be related to the biological processes such as cell adhesion and migration.
Some studies have shown that INCENP may be involved in spermatogenesis and maturation, and play a role in the regulation of sperm morphology and function.
The structure of INCENP protein has been resolved and found to possess a long, flexible tail, as well as a fragment formed with cross-linked proteins.
Customer Reviews (3)
Write a reviewLabeling effect is excellent in Western blot, which can be used for fluorescence labeling.
The catalytic activity is excellent, and the catalytic performance is stable regardless of the environment
I have recommended this brand to my colleagues and friends, and they all praise this product.
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