ING3
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Official Full Name
inhibitor of growth family, member 3
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Synonyms
ING3; inhibitor of growth family, member 3; inhibitor of growth protein 3; Eaf4; FLJ20089; MEAF4; p47ING3; ING2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ING3-112H | Recombinant Human ING3, GST-tagged | E.coli | GST | N-term-92aa | |
| Human | ING3-5207HCL | Recombinant Human ING3 293 Cell Lysate | HEK293 | N/A |
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| Human | ING3-5129H | Recombinant Human ING3 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ING3-301316H | Recombinant Human ING3 protein, GST-tagged | E.coli | GST | Met1-Phe92 |
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| Human | ING3-5876HF | Recombinant Full Length Human ING3 Protein, GST-tagged | In Vitro Cell Free System | GST | 92 amino acids |
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| Human | ING3-3884H | Recombinant Human ING3 protein, His-tagged | E.coli | His | 1-92 aa | |
| Mouse | ING3-8209M | Recombinant Mouse ING3 Protein | Mammalian Cell | His |
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| Mouse | ING3-4544M | Recombinant Mouse ING3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Ing3-3537M | Recombinant Mouse Ing3 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | ING3-4544M-B | Recombinant Mouse ING3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | ING3-3063R | Recombinant Rat ING3 Protein | Mammalian Cell | His |
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| Rat | ING3-2719R | Recombinant Rat ING3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | ING3-2719R-B | Recombinant Rat ING3 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ING3-11176Z | Recombinant Zebrafish ING3 | Mammalian Cell | His |
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| Chicken | ING3-2434C | Recombinant Chicken ING3 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ING3 Related Articles
- ING3 Related Research Area
ING3 involved in several pathways and played different roles in them. We selected most pathways ING3 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KDM5B;PHF20B;PADI1;MSL2;PRDM16;ARID2;ATXN7L3;ELP4;RBBP4 |
| Chromatin organization | ASH2L;KDM2AA;PRMT7;MTA3;MSL2B;KDM4B;KAT6A;TAF6L;KDM5C |
| HATs acetylate histones | MSL2A;C3orf75;MBIP;KAT7;CSRP2BP;MORF4L1;PHF17;ACTL6A;KAT7B |
ING3 has several biochemical functions, for example, contributes_to histone acetyltransferase activity, methylated histone binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING3 itself. We selected most functions ING3 had, and list some proteins which have the same functions with ING3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to histone acetyltransferase activity | KAT2A;TADA2A;TAF6L;SAP130;SUPT3H;TADA1;TAF5L;SUPT7L;TAF9 |
| methylated histone binding | LOXL2;LRWD1;CBX8;ZMYND11;GLYR1;MSH6;ING2;PHF2;ING5 |
| zinc ion binding | GATA1A;WTIP;PAPPA2;RNF170;FBXO11A;GM3258;ZDHHC4;EDEM3;SOD3A |
ING3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING3.
MRGBP; VPS72; RUVBL2; TRRAP; DNAJB5; KAT7; YEATS4; ACTL6A; SNRPA1; HSPA5; PLD1; EPC2; NKAP; JADE3
- Q&As
- Reviews
Q&As (7)
Ask a questionING3 recognizes histone H3 trimethylated at Lysine 4 (H3K4me3) through the Plant HomeoDomain (PHD) present at its C-terminal region.
The crystal structure of ING3’s PHD showed similarity to the PHD domains of its four homologs, suggesting a common structural motif among them.
ING3 facilitates acetylation of histones H2A and H4 by interacting with the NuA4-Tip60 MYST histone acetyltransferase complex.
The PHD of ING3 binds histone H3K4me3 with low-micromolar affinity, while its affinity for non-methylated histone is reduced by 54-fold.
The structural features explain the possible deleterious effects of ING3 mutations detected in tumors, which may disrupt its histone recognition and functional roles.
ING3 has been proposed to be an oncoprotein, suggesting its potential involvement in tumorigenesis.
The crystal structure of the N-terminal domain of ING3 revealed that it forms homodimers with an antiparallel coiled-coil fold.
Customer Reviews (3)
Write a reviewThe product’s unique attributes propelled our research to innovative heights.
Dependable protein-protein interaction outcomes were achieved due to the product's pure composition.
The product consistently met our expectations, reinforcing the credibility of our findings.
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