ING5
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Official Full Name
inhibitor of growth family, member 5
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Overview
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. -
Synonyms
ING5; inhibitor of growth family, member 5; inhibitor of growth protein 5; FLJ23842; p28ING5; 1700001C14Rik; 1700027H23Rik; 1810018M11Rik; ING 5; ING-5; Inhibitor of growth family member 5; p28 ING 5; p28 ING-5; p28 ING5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ING5 Related Articles
ING5 involved in several pathways and played different roles in them. We selected most pathways ING5 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with ING5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | KAT7;HIST2H3C;ING5A;SUZ12A;PADI6;SMYD2;SMARCC1;KDM7AB;MTA1 |
| Chromatin organization | ASH2L;PHF20B;C3orf75;ZZZ3;ARID5B;EED;KDM6AL;PBRM1;MTA1 |
| HATs acetylate histones | CSRP2BP;MORF4L1;ANO9A;PHF15;ING5B;ATXN7;YEATS4;C20orf20;USP22 |
ING5 has several biochemical functions, for example, chromatin binding, methylated histone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ING5 itself. We selected most functions ING5 had, and list some proteins which have the same functions with ING5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | MORF4L1;MED12;ING5;POU4F2;SOX14;PCGF2;BAZ1B;RNF20;UXT |
| methylated histone binding | SPIN1;ING3;WDR92;JHDM1D;PHF8;L3MBTL1;CBX8;RRP8;ATRX |
| protein binding | ITM2C;CTLA2B;TBP;NEU4;PLK2;MOB4;MID1IP1;CD163;RNF138 |
| zinc ion binding | RNF181;ING2;NR2F1;NR4A2;NR2C2;PHF21A;TRIM35-22;ADH5;ZSWIM3 |
ING5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ING5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ING5.
NAV2; CCDC67; 80125; HGS; ARFIP2; KRTAP10-7; ICA1
- Q&As
- Reviews
Q&As (7)
Ask a questionYes, ING5 is known to interact with specific histone modifications, including histone H3 trimethylated at Lysine 4 (H3K4me3).
The interaction between ING5 and H3K4me3 is important for targeting specific chromatin regions and regulating gene expression.
ING5 is known to interact with chromatin remodeling complexes, facilitating changes in chromatin structure and gene expression.
Yes, ING5 has been identified as a potential tumor suppressor, and its loss or dysfunction can contribute to tumorigenesis.
ING5 is involved in cell cycle control, and its expression can impact cell proliferation and the cell cycle progression of cells.
ING5 is a chromatin regulator that plays a role in transcriptional regulation and epigenetic
Mutations or alterations in ING5 have been reported in various cancer types, suggesting its potential role in cancer development.
Customer Reviews (3)
Write a reviewThe knowledge gained from the product's usage justified its cost, marking a prudent investment in our research endeavors.
Despite its cost, the product's contributions to our research goals made it an invaluable asset.
The product's adaptability to various buffers contributed to its stable and reliable performance.
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