inmt
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  • Official Full Name
  • indolethylamine N-methyltransferase
  • Background
  • N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene.
  • Synonyms
  • INMT; indolethylamine N-methyltransferase; Amine N methyltransferase; Amine N-methyltransferase; Aromatic alkylamine N methyltransferase; Aromatic alkylamine N-methyltransferase; Arylamine N methyltransferase; Arylamine N-methyltransferase; Indolamine N-methyltransferase; Indolethylamine N methyltransferase; INMT_HUMAN; nicotine N methyltransferase; thioester S methyltransferase like; nicotine N-methyltransferase
Cat.#:INMT-584HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INMT Protein (1-263 aa), His-SUMO-tagged
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Cat.#:INMT-2399HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human INMT Protein, MYC/DDK-tagged
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Cat.#:INMT-2400HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INMT Protein, His-tagged
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Cat.#:INMT-5114HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INMT Protein, GST-tagged
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Cat.#:INMT-115HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INMT, GST-tagged
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Cat.#:INMT-8217MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INMT Protein
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Cat.#:INMT-2272RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey INMT Protein, His-tagged
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Cat.#:INMT-347HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human INMT lysate
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Involved Pathway

INMT involved in several pathways and played different roles in them. We selected most pathways INMT participated on our site, such as Selenocompound metabolism, Tryptophan metabolism, nicotine degradation IV, which may be useful for your reference. Also, other proteins which involved in the same pathway with INMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Selenocompound metabolism
TRR1; SPS2; TXNRD1; SEPSECS; SEPHS2; CCBL2; INMT; PAPSS2A; CCBL1; TXNRD2
Tryptophan metabolism
AOX2P; TPH1A; ASMT; ABP1; OGDH; AANAT2; ALDH2.2; AOX1; ALDH9A1A.1; AOC1
nicotine degradation IV
INMT

Protein Function

INMT has several biochemical functions, for example, amine N-methyltransferase activity, protein binding, thioether S-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INMT itself. We selected most functions INMT had, and list some proteins which have the same functions with INMT. You can find most of the proteins on our site.
Function
Related Protein
Function amine N-methyltransferase activity
Related Protein INMT
Function protein binding
Related Protein KLRC4-KLRK1; SDC2; RCC1; TRAF3IP2; IFITM3; HINT2; PPP2R5A; CASP6; TMEM139; TOR1AIP2
Function thioether S-methyltransferase activity
Related Protein INMT

Interacting Protein

INMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INMT here. Most of them are supplied by our site. Hope this information will be useful for your research of INMT.
KLHL12

INMT Related Articles

Bashiri, A; Heo, HJ; et al. Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat. MOLECULAR GENETICS AND GENOMICS 289:695-705(2014).
Chu, UB; Vorperian, SK; et al. Noncompetitive Inhibition of Indolethylamine-N-methyltransferase by N,N-Dimethyltryptannine and N,N-Dimethylaminopropyltryptamine. BIOCHEMISTRY 53:2956-2965(2014).