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INPP4A

  • Official Full Name

    inositol polyphosphate-4-phosphatase, type I, 107kDa

  • Overview

    This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.
  • Synonyms

    INPP4A; inositol polyphosphate-4-phosphatase, type I, 107kDa; inositol polyphosphate 4 phosphatase, type I, 107kD , INPP4; type I inositol 3,4-bisphosphate 4-phosphatase; type I inositol-3,4-bisphosphate 4-phosphatase; INPP4; TVAS1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INPP4A-119H Recombinant Human INPP4A, GST-tagged E.coli GST N-term-301aa
Human INPP4A-2403H Recombinant Human INPP4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human INPP4A-1866H Recombinant Human INPP4A protein, His & T7-tagged E.coli His/T7 Met1~Thr137 (Accession # Q96PE3)
Human INPP4A-2352H Recombinant Human INPP4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Inpp4a-3544M Recombinant Mouse Inpp4a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Inpp4a-1867M Recombinant Mouse Inpp4a protein, His & T7-tagged E.coli His/T7 Met1~Thr137 (Accession # Q9EPW0)
Rat INPP4A-3071R Recombinant Rat INPP4A Protein Mammalian Cell His
Rat INPP4A-2727R Recombinant Rat INPP4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat INPP4A-2727R-B Recombinant Rat INPP4A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque INPP4A-2275R Recombinant Rhesus monkey INPP4A Protein, His-tagged Mammalian Cell His
Rhesus Macaque INPP4A-2096R Recombinant Rhesus Macaque INPP4A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque INPP4A-2096R-B Recombinant Rhesus Macaque INPP4A Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • INPP4A Related Articles

INPP4A involved in several pathways and played different roles in them. We selected most pathways INPP4A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismMINPP1;PIK3C2A;PIP5K1AB;IP6K3;PLCD3A;MTMR1B;TPI1B;PLCG2;NUDT4A
Metabolic pathwaysACACB;PLA2G3;NADKA;MTHFD2;Atp5k;GCH2;ASPA;WBSCR17;PPOX
Phosphatidylinositol signaling systemPLCB4;PIP5K1BB;PLCD3A;INPP5E;PPIP5K2;CALM1B;PIK3C2G;PIP5K1B;PIK3CG

INPP4A has several biochemical functions, for example, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity, phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP4A itself. We selected most functions INPP4A had, and list some proteins which have the same functions with INPP4A. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol-3,4-bisphosphate 4-phosphatase activityINPP4A;INPP4B
phosphatidylinositol-4,5-bisphosphate 4-phosphatase activityTMEM55A;INPP4A;INPP4B;TMEM55B

INPP4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP4A here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP4A.

SMAD1

Sheffer, R; Bennett-Back, O; et al. Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene. NEUROGENETICS 16:23-26(2015).
Edea, Z; Dadi, H; et al. Linkage disequilibrium and genomic scan to detect selective loci in cattle populations adapted to different ecological conditions in Ethiopia. JOURNAL OF ANIMAL BREEDING AND GENETICS 131:358-366(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What are the potential implications of INPP4A dysregulation? 03/23/2022

Dysregulation of INPP4A can have implications in cancer and other diseases, as it can alter cellular signaling pathways and contribute to abnormal cell growth.

In which cellular processes does INPP4A play a role? 03/06/2022

INPP4A is involved in regulating processes like cell proliferation, growth, and survival through its influence on inositol phosphate signaling.

Can you provide information on the molecular structure of INPP4A? 11/08/2021

INPP4A is an enzyme with a specific catalytic domain responsible for its phosphatase activity. Its structure is important for its function in inositol phosphate metabolism.

How is INPP4A activity regulated? 03/24/2021

INPP4A activity can be regulated through various mechanisms, including post-translational modifications and interactions with other proteins.

What is the role of INPP4A in cellular signaling? 11/30/2020

INPP4A is known to regulate the levels of inositol phosphates, which are important secondary messengers in various cellular signaling pathways.

What is the subcellular localization of INPP4A? 10/06/2017

INPP4A is primarily located in the cytoplasm and plays a role in regulating inositol phosphate levels within the cell.

Is there any research on INPP4A as a therapeutic target? 02/14/2016

INPP4A is a subject of research in cancer therapy, as its modulation may impact the growth and survival of cancer cells.

Customer Reviews (3)

Write a review
Reviews
11/19/2017

    We observed that results obtained with the product remained stable and reliable over long-term experiments.

    08/05/2017

      The extended longevity of results gave us the confidence to delve deeper into complex biological processes.

      06/17/2016

        The longevity of the product's effects allowed us to study cellular responses over extended timeframes.

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