INPP4B
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Official Full Name
inositol polyphosphate-4-phosphatase, type II, 105kDa
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Overview
Phosphotidylinositol lipids and phosphoinositides are important second messengers, their generation controlling many cellular events. Intracellular levels of these molecules are regulated by phosphoinositide kinases and phosphatases. One of the best chara -
Synonyms
INPP4B; inositol polyphosphate-4-phosphatase, type II, 105kDa; inositol polyphosphate 4 phosphatase, type II, 105kD; type II inositol 3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type II; type II inositol-3,4-bisphosphate 4-phospha;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
INPP4B involved in several pathways and played different roles in them. We selected most pathways INPP4B participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | MINPP1;INPP5B;OCRL;PLCD1A;INPP5E;PI4KAA;PIP4K2C;PIP5K1AA;PLCB3 |
| Metabolic pathways | MTHFS;NANSA;ACAT2;ASAH1B;UQCRFS1;PPAP2B;ADA;FUT9A;NAPRT1 |
| Phosphatidylinositol signaling system | PPIP5K1;DGKAA;ITPKA;PLCD1;MTMR7A;PLCE1;PIP4K2C;PLCG2;SYNJ2 |
INPP4B has several biochemical functions, for example, lipid binding, phosphatidylinositol trisphosphate phosphatase activity, phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP4B itself. We selected most functions INPP4B had, and list some proteins which have the same functions with INPP4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lipid binding | FABP11A;BPIFA5;RASGRP1;PTGS1;BPIFB1;PAQR5B;CYTH1;ACBD5A;BPIFB2 |
| phosphatidylinositol trisphosphate phosphatase activity | INPP4B;INPP5D;INPP5K |
| phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity | INPP4A;INPP4B |
| phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity | INPP4B;INPP4A;TMEM55A;TMEM55B |
| protein binding | NPM1;REXO1L1;RIOK3;RFC3;H2-AA;PES1;CCHCR1;RHOJ;RALB |
INPP4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP4B here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP4B.
ere_dna; PYCARD
- Q&As
- Reviews
Q&As (7)
Ask a questionINPP4B modulates cell survival by antagonizing the PI3K-AKT/PKB signaling pathway.
INPP4B hydrolyzes phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-trisphosphate.
INPP4B plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles.
INPP4B antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides.
INPP4B catalyzes the hydrolysis of the 4-position phosphate of various phosphoinositides.
The lipid phosphatase activity of INPP4B is critical for tumor suppressor function.
INPP4B modulates cell cycle progression by dephosphorylating phosphoinositides and thereby affecting cell cycle progression.
Customer Reviews (3)
Write a reviewIt's user-friendliness made it a favorite among team members, enhancing collaboration.
Time-sensitive assays were notably improved by the swift effects of the product.
The product's manufacturer went above and beyond to ensure our satisfaction, strengthening our trust in the brand.
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