INPP5B
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Official Full Name
inositol polyphosphate-5-phosphatase, 75kDa
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Overview
Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. -
Synonyms
INPP5B; inositol polyphosphate-5-phosphatase, 75kDa; inositol polyphosphate 5 phosphatase, 75kD; type II inositol-1,4,5-trisphosphate 5-phosphatase; 4; 5-trisphosphate 5-phosphatase; 5PTase; 75 kDa inositol polyphosphate 5 phosphatase; 75 kDa inositol polyphosphate-5-phosphatase; 75kDa; EC 3.1.3.36; I5P2_HUMAN; Inositol polyphosphate 5-phosphatase II; Inositol polyphosphate-5-phosphatase B; Inpp5b protein; INPP5P; MGC65156; MGC71303; OTTHUMP00000004726; OTTHUMP00000004727; OTTHUMP00000004728; Phosphoinositide 5 phosphatase; Phosphoinositide 5-phosphatase; Type II inositol 1,4,5 trisphosphate 5 phosphatase; Type II inositol-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | INPP5B-27623TH | Recombinant Human INPP5B | Wheat Germ | N/A | 748 amino acids |
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| Human | INPP5B-861HCL | Recombinant Human INPP5B cell lysate | N/A |
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| Human | INPP5B-5106H | Recombinant Human INPP5B Protein, GST-tagged | Wheat Germ | GST |
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| Human | INPP5B-258HF | Recombinant Full Length Human INPP5B Protein | In Vitro Cell Free System | 748 amino acids |
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| Human | INPP5B-5954HF | Recombinant Full Length Human INPP5B Protein, GST-tagged | In Vitro Cell Free System | GST | 748 amino acids |
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| Mouse | INPP5B-8226M | Recombinant Mouse INPP5B Protein | Mammalian Cell | His |
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| Mouse | INPP5B-4556M-B | Recombinant Mouse INPP5B Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | INPP5B-4556M | Recombinant Mouse INPP5B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- INPP5B Related Articles
INPP5B involved in several pathways and played different roles in them. We selected most pathways INPP5B participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLCZ1;INPP4B;ALDH6A1;INPPL1;PIP4K2A;PLCB1;PLCE1;PIP5K1B;PIK3C2A |
| Metabolic pathways | CKB;RDH8A;MGAT5B;DHCR24;EXT1B;ADSSL;HYAL6;PGS1;TPH1B |
| Phosphatidylinositol signaling system | PIP5K1C;PIK3R5;PIK3CA;INPP5J;PI4K2A;CALM4;PLCB1;MTMR14;CALML5 |
INPP5B has several biochemical functions, for example, inositol-1,4,5-trisphosphate 5-phosphatase activity, metal ion binding, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5B itself. We selected most functions INPP5B had, and list some proteins which have the same functions with INPP5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| inositol-1,4,5-trisphosphate 5-phosphatase activity | INPP5J;INPP5B;INPP5A;INPP5K |
| metal ion binding | TPP1;GMPR;AIFM3;RHEBL1;CYP4F14;NCALDB;FOLH1;ZFYVE27;CTDSP2 |
| phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | INPP5E;OCRL;SYNJ2;EPM2A;INPP5B;PTPMT1 |
| protein binding | UBE2N;ASAP2;SUZ12;TXN2;AP2M1;C4BP;RAB33A;POLR1C;SPG11 |
INPP5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5B here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5B.
Setdb1; Cbx4; RNASEH2A; Shoc2; KIF20A; FGFR1OP; Tuba3a; JUN; JAK3; Rmdn3; Clspn; Dync1li1; Cdc26; PARD6B; NUF2; DNAJC11
- Q&As
- Reviews
Q&As (7)
Ask a questionINPP5B is primarily located in the cytoplasm, where it functions to regulate inositol phosphate levels within the cell.
The activity of INPP5B can be regulated through post-translational modifications and interactions with other proteins.
INPP5B regulates cellular signaling by controlling the levels of inositol phosphates, which are essential secondary messengers in various cellular pathways.
INPP5B is a subject of research in cancer therapy, as its modulation may affect the behavior of cancer cells.
INPP5B is an enzyme involved in the dephosphorylation of inositol phosphates, specifically in the conversion of inositol 1,4,5-trisphosphate (IP3) to inositol 1,4-bisphosphate.
INPP5B is involved in regulating processes such as cell growth, proliferation, and cytoskeletal dynamics through its influence on inositol phosphate signaling.
Dysregulation of INPP5B can impact various cellular functions and has been associated with conditions like cancer, as it can alter signaling pathways that control cell growth and survival.
Customer Reviews (3)
Write a reviewWe found the product's straightforward protocols highly conducive to seamless integration into our lab work.
Clear and concise instructions simplified the application of the product, reducing the learning curve.
We appreciated the product's efficiency in achieving target protein upregulation with minimal time investment.
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