inpp5b
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  • Official Full Name
  • inositol polyphosphate-5-phosphatase, 75kDa
  • Background
  • Cellular calcium signaling is controlled by the production of inositol phosphates (IPs) by phospholipase C in response to extracellular signals. The IP signaling molecules are inactivated by a family of inositol polyphosphate-5-phosphatases (5-phosphatases). This gene encodes the type II 5-phosphatase. The protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
  • Synonyms
  • INPP5B; inositol polyphosphate-5-phosphatase, 75kDa; inositol polyphosphate 5 phosphatase, 75kD; type II inositol-1,4,5-trisphosphate 5-phosphatase; 4; 5-trisphosphate 5-phosphatase; 5PTase; 75 kDa inositol polyphosphate 5 phosphatase; 75 kDa inositol polyphosphate-5-phosphatase; 75kDa; EC 3.1.3.36; I5P2_HUMAN; Inositol polyphosphate 5-phosphatase II; Inositol polyphosphate-5-phosphatase B; Inpp5b protein; INPP5P; MGC65156; MGC71303; OTTHUMP00000004726; OTTHUMP00000004727; OTTHUMP00000004728; Phosphoinositide 5 phosphatase; Phosphoinositide 5-phosphatase; Type II inositol 1,4,5 trisphosphate 5 phosphatase; Type II inositol-1
Cat.#:INPP5B-5106HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INPP5B Protein, GST-tagged
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Cat.#:INPP5B-27623THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human INPP5B
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Cat.#:INPP5B-8226MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INPP5B Protein
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Cat.#:INPP5B-861HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INPP5B cell lysate
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Involved Pathway

INPP5B involved in several pathways and played different roles in them. We selected most pathways INPP5B participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
NUDT4A; PTENA; INPP4B; PI4K2A; PLCD3; SYNJ2; PTEN; PIP4K2C; PTENB; PIK3CA
Metabolic pathways
NADSYN1; MTHFD1L; MIBP; PTGS1; ACSL1A; EXT1A; COX7C; BHMT; ASAH1; FDPS
Phosphatidylinositol signaling system
SYNJ2; CALM2; TMEM55A; PRKCBA; PIK3C2G; PIK3R2; PIP4K2AA; MTMR8; PLCE1; PLCG1

Protein Function

INPP5B has several biochemical functions, for example, inositol-1,4,5-trisphosphate 5-phosphatase activity, metal ion binding, phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5B itself. We selected most functions INPP5B had, and list some proteins which have the same functions with INPP5B. You can find most of the proteins on our site.
Function
Related Protein
Function inositol-1,4,5-trisphosphate 5-phosphatase activity
Related Protein INPP5B; INPP5A; INPP5J; INPP5K
Function metal ion binding
Related Protein FBXO5; LMAN1; KLF18; XPA; POMT2; PPP3CC; LIMCH1B; DROSHA; OSGEPL1; FKBP8
Function phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Related Protein SYNJ2; INPP5B; INPP5E; OCRL; PTPMT1; EPM2A
Function protein binding
Related Protein WDFY2; RANGAP1; STIM1; pab1; GSG1; ZRANB2; GLP1R; PIK3R4; PEX19; MITF

Interacting Protein

INPP5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5B here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5B.
Setdb1; Cbx4; RNASEH2A; Shoc2; KIF20A; FGFR1OP; Tuba3a; JUN; JAK3; Rmdn3; Clspn; Dync1li1; Cdc26; PARD6B; NUF2; DNAJC11

INPP5B Related Articles

Sarantis, H; Balkin, DM; et al. Yersinia Entry into Host Cells Requires Rab5-Dependent Dephosphorylation of PI(4,5)P-2 and Membrane Scission. CELL HOST & MICROBE 11:117-128(2012).