inpp5d
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  • Official Full Name
  • inositol polyphosphate-5-phosphatase, 145kDa
  • Background
  • SHIP-1 p145 (SH2-containing-inositol phosphatase), an effector molecule, associates with activated Fms oncogenes. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 -tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.
  • Synonyms
  • INPP5D; inositol polyphosphate-5-phosphatase, 145kDa; inositol polyphosphate 5 phosphatase, 145kD; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; hp51CN; SHIP; SHIP-1; p150Ship; SH2 domain-containing inositol phosphatase 1; SH2 containing inositol phosphatase, isoform b; SH2 domain-containing inositol 5-phosphatase 1; SH2 domain-containing inositol-5-phosphatase 1; inositol polyphosphate-5-phosphatase of 145 kDa; signaling inositol polyphosphate 5 phosphatase SIP-145; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SHIP1; SIP-145; MGC104855; MGC142140; MGC142142
Cat.#:INPP5D-359HTag:Flag
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human INPP5D Protein, Flag-tagged
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Cat.#:INPP5D-8227MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INPP5D Protein
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Cat.#:INPP5D-3073RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INPP5D Protein
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Cat.#:INPP5D-5198HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INPP5D 293 Cell Lysate
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Involved Pathway

INPP5D involved in several pathways and played different roles in them. We selected most pathways INPP5D participated on our site, such as Inositol phosphate metabolism, Phosphatidylinositol signaling system, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPP5D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PLCD1A; ITPK1; PIP4K2AA; INPPL1; INPP5KA; NUDT4A; ISYNA1; INPP5A; ITPKA; PLCD3A
Phosphatidylinositol signaling system
INPP5KA; PIP5K2; IP6K3; CALM3; ITPR3; INPP5D; PPIP5K1; PIP4K2B; CALM4; PIP5K1C
B cell receptor signaling pathway
PLEKHA1; RAC3; FOS; RASGRP3; PIK3CA; AKT1; LILRB3; PPP3R1; PIK3CG; VAV2
Fc epsilon RI signaling pathway
PIK3CD; INPP5D; LYN; PIK3R2; VAV1; MAPK8; PRKCA; PLA2G4C; GM-CSF; PLCG1
Fc gamma R-mediated phagocytosis
PRKCD; ASAP2; WASL; WASF2; PIK3CA; PIK3R1; PLD1; RAF1; VASP; PRKCA

Protein Function

INPP5D has several biochemical functions, for example, PTB domain binding, SH3 domain binding, inositol-polyphosphate 5-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by INPP5D itself. We selected most functions INPP5D had, and list some proteins which have the same functions with INPP5D. You can find most of the proteins on our site.
Function
Related Protein
Function PTB domain binding
Related Protein NUP62; INPP5D; APP; INSR
Function SH3 domain binding
Related Protein ADAM15; CBL; RAD9A; CTTNBP2; CYBA; ABL1; CIT; SH3BP1; PLSCR4; RAD9
Function inositol-polyphosphate 5-phosphatase activity
Related Protein INPP5D; INPP5E; INPP5K; INPP5J; INPP5A; INPPL1
Function phosphatidylinositol trisphosphate phosphatase activity
Related Protein INPP5K; INPP4B; INPP5D
Function protein binding
Related Protein KCNJ4; Anks6; GGA1; MDM2; GPATCH8; RPL11; AIRE; CCDC117; MEIOB; TAF1B

Interacting Protein

INPP5D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPP5D here. Most of them are supplied by our site. Hope this information will be useful for your research of INPP5D.
KHDRBS3; FCGR2B; KRTAP10-7; KRTAP10-9; KRT31; KRT40