ins
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  • Official Full Name
  • insulin
  • Background
  • After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • INS; insulin; ILPR; IRDN; IDDM1; IDDM2; MODY10; proinsulin; preproinsulin; insulin-dependent diabetes mellitus 2; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
Cat.#:INS-321Tag:
Source (Host):Species:Human
Product nameSynthesis Human Proinsulin C-Peptide (55-89), bioactive peptide hormone
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Cat.#:INS-5100HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INS Protein, GST-tagged
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Cat.#:INS-856HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS Protein, His-tagged
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Cat.#:INS-256HTag:N/A
Source (Host):S. cerevisiaeSpecies:S.cerevisiae
Product nameRecombinant Human Insulin
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Cat.#:INS-14HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS
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Cat.#:INS-1759HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS protein, His & GST-tagged
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Cat.#:INS-315HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Proinsulin protein
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Cat.#:INS-320HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human INS
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Cat.#:INS-341HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human INS
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Cat.#:INS-607HTag:Met, His&Lys
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS, Met, His&Lys-tagged
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Cat.#:INS-674HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS Protein, His/GST-tagged
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Cat.#:INS-88HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS, His-tagged
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Cat.#:INS-561MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse INS protein, His-tagged
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Cat.#:INS-623CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus INS Protein, His-tagged
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Cat.#:INS-6775CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken INS
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Cat.#:INS-679RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit INS Protein, His/GST-tagged
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Cat.#:INS-8684ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish INS
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Cat.#:Ins-1783GTag:His/SUMO
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Ins protein, His & SUMO-tagged
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Cat.#:INS-41PTag:N/A
Source (Host):Porcine Pancreas.Species:Pig
Product namePorcine Insulin
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Cat.#:INS-560CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle INS protein, His & GST-tagged
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Cat.#:INS-673CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle INS Protein, His/GST-tagged
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Cat.#:INS-676PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig INS Protein, His/GST-tagged
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Cat.#:INS-677PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig INS Protein, His/GST-tagged
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Cat.#:INS-5308HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin
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Cat.#:INS-5435BTag:N/A
Source (Host):Bovine pancreasSpecies:Bovine
Product nameNative Bovine Insulin
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Cat.#:INS-512DTag:
Source (Host):beef pancreasSpecies:Beef
Product nameNative Bovine INS
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Cat.#:INS-5195HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INS 293 Cell Lysate
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Cat.#:INS-194HTag:
Source (Host):Species:Human
Product nameHuman Proinsulin Reference standard
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Cat.#:INS-69HTag:
Source (Host):Species:Human
Product nameHuman Insulin Reference standard
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Cat.#:INS-193BTag:
Source (Host):Species:Bovine
Product nameBovine Proinsulin Reference standard
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Cat.#:INS-72BTag:
Source (Host):Species:Bovine
Product nameBovine Insulin Reference standard
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Cat.#:INS-74PTag:
Source (Host):Species:Pig
Product namePorcine Insulin Reference standard
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Cat.#:INS-P040HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P039HTag:
Source (Host):Species:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P056HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P057HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P060HTag:
Source (Host):Saccharomyces cerevisiaeSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P061HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Involved Pathway

INS involved in several pathways and played different roles in them. We selected most pathways INS participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
RAB5C; PRKACG; RAC1; MAPK10; RRAS; FGF8; FLT4; KSR2; GNG12; SOS1
Rap signaling pathway
LPAR4; PLCB1; FLT1; FGF7; HGF; INS; VEGFB; SRC; MAPK1; PDGFA
cGMP-PKG signaling pathway
ROCK1; RAF1; PIK3R2; LOC100328615; CALML3; AGTR1A; IRS4; MEF2B; GNA12; NOS3
HIF- signaling pathway
Trf; NOX3; VHL; EPO; PIK3R2; ARNT; EGLN1; RBX1; PFKL; PFKFB3
FoxO signaling pathway
SGK1; AKT1; PIK3R1; PTENB; STK11; PIK3CA; SKP2; PLK4; ATM; FOXO3
Phospholipase D signaling pathway
PIK3R5; PIP5K1A; PLCB3; INS; DGKD; KRAS; GAB2; PPAP2A; LPAR4; LPAR2
Oocyte meiosis
YWHAG; MAD2L1; PPP2R1B; YWHAE; RPS6KA3A; PPP2R5CB; YWHAZ; IGF1R; CDC23; PRKACAA
Regulation of autophagy
IFNA4; IFNA6; GABARAPL2; INS; IFNA8; IFNA5; ATG16L1; ATG10; PIK3R4; IFNA1
mTOR signaling pathway
RPS6KA2; PDPK1B; EIF4BB; AKT2; TSC1; VEGFAB; RPTOR; PRR5; PTENA; AKT2L
PIK-Akt signaling pathway
FGF21; TCL1B; AKT1; PDGFC; PRKCA; COL6A6; HSP90AB1; MTOR; INS; PTK2
AMPK signaling pathway
CAB39L; GYS1; PPP2R5E; PPP2R3A; CREB1; CAMKK2; FOXO3; ACACA; PIK3R1; CREB3L3
Regulation of actin cytoskeleton
ACTN3; FGF1B; CHRM2A; MAP2K2; ARPC5L; FN1; FGFR2; ITGB2L; FGFR1A; PXNA
Insulin signaling pathway
PPP1CB; RHOQ; ACACA; PDPK1B; FLOT1A; ELK1; PRKAR1A; KRAS; CALM2A; IRS4
Insulin secretion
ATP1B2; CREB3L3; GLP1R; Adcy4; RAPGEF4; VAMP2; ATP1B1; CREB5; CAMK2G; CAMK2B
Ovarian steroidogenesis
FSHR; INS1; SCARB1; CYP2J5; GDF9; BMP15; LDLR; LHCGR; HSD17B1; HSD3B2
Progesterone-mediated oocyte maturation
GNAI2B; BRAF; MAPK8B; HSP90AB1; MAD1L1; ANAPC11; PRKACBB; ADCY1A; CDC25A; PDE3B
Prolactin signaling pathway
KRAS; SHC3; PIK3CB; MAP2K1; SLC2A2; INS2; SIRPA; SOS1; RAF1; MAPK12
Regulation of lipolysis in adipocytes
PIK3CD; PNPLA2; AQP7; LOC100328615; ABHD5; PTGS2; NPR1; PIK3CB; PRKACB; FABP4
Type II diabetes mellitus
INS; MAPK1; IRS4; PIK3R5; PKM2; INS-IGF2; ADIPOQ; IRS1; PIK3R1; PIK3CA
Insulin resistance
PTPN11; INS1; IRS1; PPP1CA; NFKBIAA; PPP1CBL; ACACB; MAPK10; SLC2A1; SOCS3B
Non-alcoholic fatty liver disease (NAFLD)
SDHD; FASLG; COX7A2L; NDUFC1; MAP3K11; INS2; FAS; UQCRB; INS1; CYCS
Type I diabetes mellitus
HLA-F; HLA-DMA; CD86; FASLG; CPE; HLA-DOA; HLA-DPA1; Il2; HLA-DRB3; HLA-DQA1
Maturity onset diabetes of the young
HNF1B; PDX1; RFX6; MAFA; NEUROG3; IAPP; PAX6; NKX6-1; INS2; MNX1
Aldosterone-regulated sodium reabsorption
IGF1; ATP1A2; SFN; PIK3R3; ATP1B3; PIK3CA; PIK3CD; ATP1A4; KRAS; PIK3R1
Prostate cancer
AKT2; SMARCD1; NKX3-1; PTEN; CREB3L3; PIK3CD; TP53; FOXA1; BRAF; PDGFD

Protein Function

INS has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INS itself. We selected most functions INS had, and list some proteins which have the same functions with INS. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein GNRH2; ADM; SST3; POMCA; SCT; C1QTNF9; PTH; SST; ADCYAP1A; POMCB
Function identical protein binding
Related Protein APLP1; BIN1; FBXW7; KCNRG; AXIN1; PKD2; SAFB2; DYNLT1C; DCP1A; RBM10
Function insulin receptor binding
Related Protein IRS4; INS2; FRS2; SLC2A2; PIK3R1; ENPP1; DOK1; PTPN1; IGF1R; IGF1
Function insulin-like growth factor receptor binding
Related Protein GNAS; IRS1; ARRB1; IGF2A; PIK3R1; INSL4; IGF2; SOCS1; IGF3; INS
Function protease binding
Related Protein SERPINA1E; CCDC71L; BDKRB2; RNF139; NFRKB; INS2; TIMP4; COMP; Serpina1b; OS9
Function protein binding
Related Protein HDAC7; ID4; RYR1; RABEP1; TXNDC12; CDK11B; GP6; ANO6; CREB1; WFS1

Interacting Protein

INS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INS here. Most of them are supplied by our site. Hope this information will be useful for your research of INS.
DCN; MAPK6