ins
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  • Official Full Name
  • insulin
  • Background
  • After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • INS; insulin; ILPR; IRDN; IDDM1; IDDM2; MODY10; proinsulin; preproinsulin; insulin-dependent diabetes mellitus 2; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519
Cat.#:INS-321Tag:
Source (Host):Species:Human
Product nameSynthesis Human Proinsulin C-Peptide (55-89), bioactive peptide hormone
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Cat.#:INS-5100HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human INS Protein, GST-tagged
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Cat.#:INS-856HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS Protein, His-tagged
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Cat.#:INS-256HTag:N/A
Source (Host):S. cerevisiaeSpecies:S.cerevisiae
Product nameRecombinant Human Insulin
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Cat.#:INS-14HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS
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Cat.#:INS-1759HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS protein, His & GST-tagged
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Cat.#:INS-315HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Proinsulin protein
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Cat.#:INS-320HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human INS
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Cat.#:INS-341HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human INS
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Cat.#:INS-607HTag:Met, His&Lys
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS, Met, His&Lys-tagged
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Cat.#:INS-674HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS Protein, His/GST-tagged
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Cat.#:INS-88HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS, His-tagged
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Cat.#:INS-561MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse INS protein, His-tagged
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Cat.#:INS-623CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus INS Protein, His-tagged
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Cat.#:INS-6775CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken INS
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Cat.#:INS-679RTag:His/GST
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit INS Protein, His/GST-tagged
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Cat.#:INS-8684ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish INS
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Cat.#:Ins-1783GTag:His/SUMO
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Guinea pig Ins protein, His & SUMO-tagged
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Cat.#:INS-41PTag:N/A
Source (Host):Porcine Pancreas.Species:Pig
Product namePorcine Insulin
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Cat.#:INS-560CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle INS protein, His & GST-tagged
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Cat.#:INS-673CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle INS Protein, His/GST-tagged
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Cat.#:INS-676PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig INS Protein, His/GST-tagged
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Cat.#:INS-677PTag:His/GST
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig INS Protein, His/GST-tagged
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Cat.#:INS-5308HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Insulin
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Cat.#:INS-5435BTag:N/A
Source (Host):Bovine pancreasSpecies:Bovine
Product nameNative Bovine Insulin
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Cat.#:INS-512DTag:
Source (Host):beef pancreasSpecies:Beef
Product nameNative Bovine INS
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Cat.#:INS-5195HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INS 293 Cell Lysate
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Cat.#:INS-194HTag:
Source (Host):Species:Human
Product nameHuman Proinsulin Reference standard
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Cat.#:INS-69HTag:
Source (Host):Species:Human
Product nameHuman Insulin Reference standard
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Cat.#:INS-193BTag:
Source (Host):Species:Bovine
Product nameBovine Proinsulin Reference standard
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Cat.#:INS-72BTag:
Source (Host):Species:Bovine
Product nameBovine Insulin Reference standard
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Cat.#:INS-74PTag:
Source (Host):Species:Pig
Product namePorcine Insulin Reference standard
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Cat.#:INS-P040HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P039HTag:
Source (Host):Species:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P056HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P057HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P060HTag:
Source (Host):Saccharomyces cerevisiaeSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Cat.#:Insulin-P061HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INS therapeutic protein
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Involved Pathway

INS involved in several pathways and played different roles in them. We selected most pathways INS participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ras signaling pathway
FASLG; SHC4; KSR2; RAPGEF5; MET; ETS2; RAC3; FGF3; MAP2K2; GRIN2B
Rap signaling pathway
RAC2; FYB; SIPA1L1; GRIN1; PLCB4; RAPGEF1; THBS1; FGF7; ANGPT1; FGF6
cGMP-PKG signaling pathway
PLCB4; ATP1B4; PRKG2; CREB5; PDE3B; INS1; GTF2IRD1; GNA12; PIK3CB; VDAC2
HIF- signaling pathway
FLT1; EP300; PLCG2; IFNGR1; MKNK2; PDHA1; TCEB1; AKT2; INS; VHL
FoxO signaling pathway
TGFBR1B; IGF1; PIK3CD; CCND2; PRKAA2; GABARAPL2; FOXG1; BRAF; STK11; CDKN1BB
Phospholipase D signaling pathway
INS1; PIP5K1C; INSR; GNA12; GRM4; AGPAT5; AVPR2; PPAP2A; GRM6; SHC3
Oocyte meiosis
CAMK2G; CCNE2; CALM4; PPP2R5CB; ADCY1B; YWHABL; FBXO43; YWHAE2; PPP2R5B; CDC26
Regulation of autophagy
INS2; ATG4C; ATG10; ATG16L1; ULK1; ATG4A; IFNA13; ATG4B; IFNA12; BECN1
mTOR signaling pathway
AKT1S1; BRAF; IGF1; RB1CC1; PRKCBA; PTENA; AKT2; INSB; EIF4BB; DEPDC6
PIK-Akt signaling pathway
PPP2R5D; RELA; VWF; YWHAE; IFNA16; PIK3CD; ITGB6; LPAR4; PPP2R2C; TEK
AMPK signaling pathway
CPT1A; PPP2R3C; ULK1; PPP2R2C; AKT1; ADIPOR1; PRKAA2; CCND1; RAB11B; RPS6KB2
Regulation of actin cytoskeleton
PIK3CG; RAF1B; MYH10; ITGA7; ARHGEF1; Fgf15; ITGAM; ITGA10; CYFIP1; PPP1CC
Insulin signaling pathway
PTPRF; TSC1A; PPP1R3CB; PRKAR1AB; PRKAA1; PRKACBB; AKT1; AKT3A; FLOT1A; ACACA
Insulin secretion
KCNN1; KCNMB1; CREB5; KCNJ11; CREB3L1; PLCB4; CAMK2B; PDX1; SLC2A1; ATP1A1
Ovarian steroidogenesis
PLA2G4C; IGF1R; FSHR; HSD3B5; LHB; HSD3B1; PLA2G4D; INS; Adcy4; IGF1
Progesterone-mediated oocyte maturation
PRKACA; FZR1; ANAPC1; CDC25B; PIK3R3; MAPK13; ADCY1B; PGR; PRKACBB; CDC16
Prolactin signaling pathway
INS1; PIK3CB; SIRPA; MAPK10; SOCS4; SOCS5; TNFRSF11A; SOCS6; SOCS2; INS2
Regulation of lipolysis in adipocytes
ABHD5; PIK3CG; PDE3B; PIK3R1; GNAS; NPY1R; TSHR; NPY; PIK3CD; Adcy4
Type II diabetes mellitus
PIK3R2; PDX1; INSR; MTOR; IRS1; IRS4; MAPK9; PIK3R1; INS1; HK3
Insulin resistance
CREB5; NR1H3; PRKAB1B; PPP2R4; PRKAA1; RELA; PRKCQ; CREB3L1; CRTC2; PRKAG1
Non-alcoholic fatty liver disease (NAFLD)
AKT2; UQCR10; NFKB1; CEBPA; NDUFC2-KCTD14; ERN1; NDUFC2; PRKAB2; NDUFS1; PKLR
Type I diabetes mellitus
INS1; Fasl; PTPRN2; FASLG; HLA-A; HSPD1; HLA-C; INS; HLA-DMB; INS2
Maturity onset diabetes of the young
NKX6; NEUROG3; MNX1; PAX6; NR5A2; HNF1B; HES1; PDX1; INS; IAPP
Aldosterone-regulated sodium reabsorption
PIK3R3; PIK3R1; KRAS; NR3C2; PIK3CA; PRKCG; SFN; INS; PIK3CD; HSD11B2
Prostate cancer
NFKBIA; MTOR; PDGFC; BRAF; CREB3L2; MDM2; HRAS; SMARCD1; NKX3; INS

Protein Function

INS has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INS itself. We selected most functions INS had, and list some proteins which have the same functions with INS. You can find most of the proteins on our site.
Function
Related Protein
Function hormone activity
Related Protein UTS2A; GH2; BNP; IAPP; INS-IGF2; INS2; TSHB; RLN3A; PRLH; INSL4
Function identical protein binding
Related Protein LRRK1; PDGFB; BNIP2; KLHL7; ADIPOQ; ATXN3; ESYT2; TRIM21; GSTM3; BNIP3L
Function insulin receptor binding
Related Protein IGF1; FRS2; GRB10; DOK3; FRS2B; SNX1; DOK1B; SHC1; LMBRD1; DOK4
Function insulin-like growth factor receptor binding
Related Protein IGF2B; REN; IGF2; YWHAG; INS; IGF1; ARRB1; SOCS1; Ren1; YWHAH
Function protease binding
Related Protein SERPINB4; CCDC71L; DPP4; CD28; CAST; FADD; BCL2; SERPINA1A; CD70; KIT
Function protein binding
Related Protein DHPS; PCGF6; KIF22; PDCD1; MTMR7; SMAD7; MAP4; PRDM10; TFDP2; CUL2

Interacting Protein

INS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INS here. Most of them are supplied by our site. Hope this information will be useful for your research of INS.
DCN; MAPK6