insig1
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  • Official Full Name
  • insulin induced gene 1
  • Background
  • Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • INSIG1; insulin induced gene 1; insulin-induced gene 1 protein; CL 6; INSIG 1 membrane protein; MGC1405; CL6; INSI1_HUMAN; INSIG 1; INSIG-1; INSIG1 membrane protein; Insulin induced gene 1 protein; INSIG-1 membrane protein; CL-6
Cat.#:INSIG1-124HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human INSIG1, His-tagged
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Cat.#:INSIG1-8236MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse INSIG1 Protein
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Cat.#:INSIG1-3078RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat INSIG1 Protein
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Cat.#:INSIG1-624CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus INSIG1 Protein, His-tagged
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Cat.#:INSIG1-2654CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken INSIG1
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Cat.#:INSIG1-10242ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish INSIG1
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Cat.#:INSIG1-5193HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INSIG1 293 Cell Lysate
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Cat.#:INSIG1-5194HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human INSIG1 293 Cell Lysate
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Involved Pathway

INSIG1 involved in several pathways and played different roles in them. We selected most pathways INSIG1 participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Regulation of cholesterol biosynthesis by SREBP (SREBF), which may be useful for your reference. Also, other proteins which involved in the same pathway with INSIG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolism
MMS19; ISCUB; ABHD4; CYP4B1; FA2H; MED31; ACER1; CYGB2; CA13; ARL2BP
Metabolism of lipids and lipoproteins
MED10; PLD6; GRHL1; CYP27B1; APOF; AGPAT6; CERS3B; GLTPA; CPTP; SACM1LB
Regulation of cholesterol biosynthesis by SREBP (SREBF)
DHCR7; NFYAL; NFYBB; NFYBA; PMVK; INSIG2; MTF1; YY2; INSIG1; SREBF2
SREBP signalling
SEC23B; RBP4; INSIG2; INSIG1; RNF139; DBI

Protein Function

INSIG1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSIG1 itself. We selected most functions INSIG1 had, and list some proteins which have the same functions with INSIG1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein NRP1; RAD18; ZBTB5; Akap3; NR5A1; CSPP1; PYCARD; CASQ2; FAM64A; PLXDC1

Interacting Protein

INSIG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSIG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSIG1.
SEC27; copa_schpo; CYP2C1; CYP2C2; COP1

INSIG1 Related Articles

Wang, WX; Wilfred, BR; et al. Individual microRNAs (miRNAs) display distinct mRNA targeting "rules". RNA BIOLOGY 7:373-380(2010).