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INSIG2

  • Official Full Name

    insulin induced gene 2

  • Synonyms

    Insig-2; 2900053I11Rik; C730043J18Rik;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Papio anubis (Olive baboon)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • Xenopus laevis (African clawed frog)
  • Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Protein Conjugation
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INSIG2-5192HCL Recombinant Human INSIG2 293 Cell Lysate HEK293 N/A
Human INSIG2-2114H Recombinant Human INSIG2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human INSIG2-5098H Recombinant Human INSIG2 Protein, GST-tagged Wheat Germ GST
Human INSIG2-4331H Recombinant Human INSIG2 Full Length Transmembrane protein, His&Myc-tagged In vitro E. coli expression system His&Myc 1-225aa
Human INSIG2-5982HF Recombinant Full Length Human INSIG2 Protein, GST-tagged In Vitro Cell Free System GST 225 amino acids
Human INSIG2-1720HFL Recombinant Full Length Human INSIG2 Protein, C-Flag-tagged Mammalian cells Flag
Human INSIG2-1188H Recombinant Human INSIG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human INSIG2-2820H Recombinant Human INSIG2 Protein, His-tagged, OVA Conjugated Protein Conjugation N-His Met1-Pro16
Human INSIG2-1188H-B Recombinant Human INSIG2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Insig2-3552M Recombinant Mouse Insig2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat INSIG2-3079R Recombinant Rat INSIG2 Protein Mammalian Cell His
Rat INSIG2-2735R Recombinant Rat INSIG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat INSIG2-2735R-B Recombinant Rat INSIG2 Protein Pre-coupled Magnetic Beads HEK293
Callithrix jacchus (White-tufted-ear marmoset) RFL36643CF Recombinant Full Length Callithrix Jacchus Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-225)
Gallus gallus (Chicken) RFL6710GF Recombinant Full Length Chicken Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-167)
Homo sapiens (Human) RFL24215HF Recombinant Full Length Human Insulin-Induced Gene 2 Protein(Insig2) Protein, His&Myc-Tagged E.coli expression system His&Myc Full Length (1-225aa)
Mus musculus (Mouse) RFL7463MF Recombinant Full Length Mouse Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-225)
Papio anubis (Olive baboon) RFL21862PF Recombinant Full Length Papio Anubis Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-225)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL27451PF Recombinant Full Length Pongo Abelii Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-238)
Rattus norvegicus (Rat) RFL9077RF Recombinant Full Length Rat Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-225)
Rhesus Macaque INSIG2-2279R Recombinant Rhesus monkey INSIG2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque INSIG2-2100R-B Recombinant Rhesus Macaque INSIG2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque INSIG2-2100R Recombinant Rhesus Macaque INSIG2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Sus scrofa (Pig) RFL10815SF Recombinant Full Length Pig Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-225)
Xenopus laevis (African clawed frog) RFL32211XF Recombinant Full Length Xenopus Laevis Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-218)
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) RFL26196XF Recombinant Full Length Xenopus Tropicalis Insulin-Induced Gene 2 Protein(Insig2) Protein, His-Tagged E.coli expression system His Full Length (1-218)
Zebrafish INSIG2-12070Z Recombinant Zebrafish INSIG2 Mammalian Cell His
Chicken INSIG2-2919C Recombinant Chicken INSIG2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

INSIG2 involved in several pathways and played different roles in them. We selected most pathways INSIG2 participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Regulation of cholesterol biosynthesis by SREBP (SREBF), which may be useful for your reference. Also, other proteins which involved in the same pathway with INSIG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismKIAA1199;ARV1;PDK2B;ALDH9A1A.2;NEU3;UGT1B4;GLYATL2;UPP2;SAT1B
Metabolism of lipids and lipoproteinsESRRA;FABP11A;MED23;THEM5;APOA4A;PPP1R2;Agmo;GC;APOC2
Regulation of cholesterol biosynthesis by SREBP (SREBF)NFYBB;PMVK;DHCR7;INSIG2;NFYBA;INSIG1;SREBF2;NFYAL;YY2
SREBP signallingDBI;SEC23B;INSIG2;INSIG1;RBP4;RNF139

INSIG2 has several biochemical functions, for example, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSIG2 itself. We selected most functions INSIG2 had, and list some proteins which have the same functions with INSIG2. You can find most of the proteins on our site.

Function Related Protein
protein bindingPROP1;NUDT14;KLF5;THOC5;ACTG1;MASP2;IGF2BP3;C11orf49;CACNB2
transcription factor bindingSP100;SMAD2;GTF2F1;CTBP1;ENPP2;TAF12;MED12;SIRT1;BCL3

INSIG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSIG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSIG2.

RNF5; SEC27; copa_schpo; COP1

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there any post-translational modifications known to regulate INSIG2? 11/02/2020

While specific post-translational modifications may exist, the current literature provides limited information on post-translational regulation of INSIG2.

How does INSIG2 contribute to insulin sensitivity? 02/18/2020

INSIG2 contributes to insulin sensitivity by regulating lipid metabolism and insulin signaling pathways.

How does INSIG2 impact the activity of SREBP-1 and SREBP-2? 12/08/2019

INSIG2 inhibits the activity of both SREBP-1 and SREBP-2, impacting lipogenesis and cholesterol biosynthesis.

What is the relationship between INSIG2 and cholesterol synthesis? 06/21/2019

INSIG2 is a key regulator of cholesterol synthesis, modulating the activation of SREBP-2, a master regulator of cholesterol biosynthesis.

What is the role of INSIG2 in cellular response to ER stress? 12/01/2018

INSIG2 is involved in the cellular response to ER stress, playing a role in maintaining ER homeostasis.

Is there evidence of INSIG2 involvement in cancer development? 05/12/2018

There is evidence linking INSIG2 to cancer development, suggesting a potential role in tumorigenesis.

Does INSIG2 expression vary in response to different dietary conditions? 04/21/2018

Yes, INSIG2 expression can vary in response to different dietary conditions, reflecting its role in metabolic adaptation.

Customer Reviews (3)

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Reviews
08/16/2020

    We observed that results obtained with the product remained stable and reliable over long-term experiments.

    01/11/2020

      The product's impact extended to data analysis, with intuitive tools for interpreting experimental results.

      07/07/2017

        Its adaptability to various sample types and conditions made it a valuable asset for our diverse projects.

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