INSIG2
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Official Full Name
insulin induced gene 2
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Synonyms
Insig-2; 2900053I11Rik; C730043J18Rik;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Callithrix jacchus (White-tufted-ear marmoset)
- Chicken
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Papio anubis (Olive baboon)
- Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Macaque
- Sus scrofa (Pig)
- Xenopus laevis (African clawed frog)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Zebrafish
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Mammalian cells
- Protein Conjugation
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
INSIG2 involved in several pathways and played different roles in them. We selected most pathways INSIG2 participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Regulation of cholesterol biosynthesis by SREBP (SREBF), which may be useful for your reference. Also, other proteins which involved in the same pathway with INSIG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Metabolism | KIAA1199;ARV1;PDK2B;ALDH9A1A.2;NEU3;UGT1B4;GLYATL2;UPP2;SAT1B |
Metabolism of lipids and lipoproteins | ESRRA;FABP11A;MED23;THEM5;APOA4A;PPP1R2;Agmo;GC;APOC2 |
Regulation of cholesterol biosynthesis by SREBP (SREBF) | NFYBB;PMVK;DHCR7;INSIG2;NFYBA;INSIG1;SREBF2;NFYAL;YY2 |
SREBP signalling | DBI;SEC23B;INSIG2;INSIG1;RBP4;RNF139 |
INSIG2 has several biochemical functions, for example, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSIG2 itself. We selected most functions INSIG2 had, and list some proteins which have the same functions with INSIG2. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | PROP1;NUDT14;KLF5;THOC5;ACTG1;MASP2;IGF2BP3;C11orf49;CACNB2 |
transcription factor binding | SP100;SMAD2;GTF2F1;CTBP1;ENPP2;TAF12;MED12;SIRT1;BCL3 |
INSIG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSIG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSIG2.
RNF5; SEC27; copa_schpo; COP1
- Q&As
- Reviews
Q&As (7)
Ask a questionWhile specific post-translational modifications may exist, the current literature provides limited information on post-translational regulation of INSIG2.
INSIG2 contributes to insulin sensitivity by regulating lipid metabolism and insulin signaling pathways.
INSIG2 inhibits the activity of both SREBP-1 and SREBP-2, impacting lipogenesis and cholesterol biosynthesis.
INSIG2 is a key regulator of cholesterol synthesis, modulating the activation of SREBP-2, a master regulator of cholesterol biosynthesis.
INSIG2 is involved in the cellular response to ER stress, playing a role in maintaining ER homeostasis.
There is evidence linking INSIG2 to cancer development, suggesting a potential role in tumorigenesis.
Yes, INSIG2 expression can vary in response to different dietary conditions, reflecting its role in metabolic adaptation.
Customer Reviews (3)
Write a reviewWe observed that results obtained with the product remained stable and reliable over long-term experiments.
The product's impact extended to data analysis, with intuitive tools for interpreting experimental results.
Its adaptability to various sample types and conditions made it a valuable asset for our diverse projects.
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