INSL3
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Official Full Name
insulin-like 3 (Leydig cell)
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Overview
The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism. -
Synonyms
INSL3; insulin-like 3 (Leydig cell); relaxin like factor , RLNL; insulin-like 3; MGC119818; MGC119819; RLF; ley-I-L; relaxin-like factor b; leydig insulin-like peptide; leydig insulin -like hormone; leydig insulin -like peptide; RLNL;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- INSL3 Related Articles
- INSL3 Related Research Area
INSL3 involved in several pathways and played different roles in them. We selected most pathways INSL3 participated on our site, such as Class A/1 (Rhodopsin-like receptors), G alpha (s) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with INSL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | EDN3;RLN2;EDNRAB;PPY;NMU;GPBAR1;OPN4.1;GPR132;CNR1 |
| G alpha (s) signalling events | VIP2;CALCB;NPS;PDE10A;PTHLHA;CRHR1;SCT;ADCYAP1R1;RXFP2 |
| GPCR downstream signaling | TAS2R16;SSTR5;GPR55A;TRPC6A;UTS2D;OXGR1A.3;NET1;PTHLHA;KALRNB |
| GPCR ligand binding | EMR1;TAAR1;SST;OPN1SW1;OPN5;ADCYAP1B;CXCR6;LPAR5A;PENK |
| Peptide ligand-binding receptors | OXTRL;CCRL2;QRFP;PNOC;UTS2;CCBP2;FPR-RS6;NMBB;NTS |
| Relaxin receptors | INSL5;RLN2;INSL3;RXFP2;RLN3A;RLN3 |
| Signal Transduction | PTPRK;ARHGAP28;GMIP;NEDD8L;TNKS2;PDE10A;RGS1;S1PR3;SKI |
| Signaling by GPCR | NET1;OR52B4;CALCB;RAMP3;CCBP2;OR10A5;MLN;GHRH;ARHGEF1B |
INSL3 has several biochemical functions, for example, G-protein coupled receptor binding, hormone activity, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSL3 itself. We selected most functions INSL3 had, and list some proteins which have the same functions with INSL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein coupled receptor binding | HSPA1A;USP33;ITGB4;GNA12A;RLN3;NPFF;HSPA8;GNA15.4;AKAP5 |
| hormone activity | INS-IGF2;LEPB;URP2;INSL5;GCGB;PYYA;STC1L;THPO;LEPA |
| insulin receptor binding | FRS2A;INS1;SNX2;ENPP1;FRS2B;IRS1;FRS2;DOK7;SLC2A2 |
| protease binding | FLOT1;SERPINA1E;TRP53;SELL;XBP1;DPP4;LRP1;PEO1;SRI |
| receptor binding | MYO1C;FKBP1B;TNFSF12;GUSB;INSL4;SLC9A3R1;CX3CL1;FGF18B;NRTN |
INSL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSL3.
- Q&As
- Reviews
Q&As (7)
Ask a questionINSL3 is prominently expressed in the testes, but it is also found in the ovaries and other tissues.
During fetal development, INSL3 expression is crucial for proper testicular descent, a process essential for male reproductive health.
INSL3 is regulated at the transcriptional level by various factors, including hormones such as luteinizing hormone (LH).
INSL3 plays a vital role in reproductive physiology by promoting testicular descent during fetal development and supporting spermatogenesis in adulthood.
Beyond reproduction, INSL3 may have metabolic effects, potentially influencing bone metabolism and insulin sensitivity.
In the female reproductive system, INSL3 is involved in ovarian follicle development and is produced by theca cells.
Research suggests a correlation between INSL3 levels in semen and male fertility, making it a potential biomarker.
Customer Reviews (3)
Write a reviewUser-friendly data analysis capabilities contributed to the product's overall value for our research.
The product's adaptability to custom protocols empowered us to explore innovative experimental setups.
The ability to use the product across different scientific disciplines broadened the scope of our investigations.
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