INSL4
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Official Full Name
insulin-like 4 (placenta)
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Overview
INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. -
Synonyms
INSL4; insulin-like 4 (placenta); early placenta insulin-like peptide; EPIL; early placenta insulin like peptide (EPIL); Early placenta insulin like peptide A chain; Early placenta insulin like peptide; Early placenta insulin like peptide B chain; Early placenta insulin-like peptide A chain; INSL4_HUMAN; insulin like 4; insulin like 4 (placenta); Insulin like peptide 4; Insulin-like peptide 4; OTTHUMP00000021025; Placentin; early placenta insulin-like peptide (EPIL);
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- C
- His
- GST
- GST|His
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | INSL4-319H | Recombinant Human INSL4 protein(Met1-Thr139), His-tagged | HEK293 | C-His | Met1-Thr139 | |
Human | INSL4-118H | Recombinant Human INSL4, His-tagged | HEK293 | His | ||
Human | INSL4-723H | Recombinant Human INSL4 Protein, GST-His-tagged | E.coli | GST/His | ||
Human | INSL4-001HCL | Recombinant Human INSL4 cell lysate | Human Cell | N/A | ||
Human | INSL4-3117H | Recombinant Human INSL4 Protein (Ala26-Thr139), C-His tagged | Mammalian cells | C-His | Ala26-Thr139 | |
Human | INSL4-5984HF | Recombinant Full Length Human INSL4 Protein, GST-tagged | In Vitro Cell Free System | GST | 26-139 amino acids | |
Human | INSL4-5096H | Recombinant Human INSL4 Protein, GST-tagged | Wheat Germ | GST |
- Involved Pathway
- Protein Function
- Interacting Protein
- INSL4 Related Articles
- INSL4 Related Research Area
INSL4 involved in several pathways and played different roles in them. We selected most pathways INSL4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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INSL4 has several biochemical functions, for example, hormone activity, insulin-like growth factor receptor binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSL4 itself. We selected most functions INSL4 had, and list some proteins which have the same functions with INSL4. You can find most of the proteins on our site.
Function | Related Protein |
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hormone activity | FNDC5;BMP10;IGF3;GCG;INHBA;C19orf80;GPHA2;PRL8A9;PRL2C2 |
insulin-like growth factor receptor binding | Ren1;IRS1;INS;GNAS;YWHAG;INS2;SHC1;IGF3;SOCS2 |
receptor binding | HNF4A;TNFSF18;SRPX2;HAND2;TRIM24;ABCA1;FGF12A;CADM1B;ANGPT2 |
INSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSL4.
- Q&As
- Reviews
Q&As (7)
Ask a questionModulating INSL4 activity could have therapeutic implications for conditions related to reproductive health and pregnancy.
In pathological conditions like preeclampsia, there are alterations in INSL4 expression levels, indicating a potential link to pregnancy-related complications.
Research indicates genetic variations in the INSL4 gene may be linked to recurrent pregnancy loss and fertility issues.
INSL4 is associated with endometrial receptivity, particularly during the window of implantation, suggesting involvement in successful pregnancy establishment.
INSL4 may play a role in early embryonic development, potentially influencing processes like blastocyst implantation and embryo-maternal communication.
While primarily associated with reproductive processes, INSL4 may have additional roles in non-reproductive physiological processes, warranting further investigation.
INSL4 influences trophoblast invasion, contributing to placental development, a critical aspect of successful pregnancy.
Customer Reviews (3)
Write a reviewTailoring the product to our unique experimental conditions enhanced the precision of our results.
The longevity of the product's effects allowed us to study cellular responses over extended timeframes.
We found that the product's support for data analysis and visualization significantly expedited our research.
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