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INSL4

  • Official Full Name

    insulin-like 4 (placenta)

  • Overview

    INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.
  • Synonyms

    INSL4; insulin-like 4 (placenta); early placenta insulin-like peptide; EPIL; early placenta insulin like peptide (EPIL); Early placenta insulin like peptide A chain; Early placenta insulin like peptide; Early placenta insulin like peptide B chain; Early placenta insulin-like peptide A chain; INSL4_HUMAN; insulin like 4; insulin like 4 (placenta); Insulin like peptide 4; Insulin-like peptide 4; OTTHUMP00000021025; Placentin; early placenta insulin-like peptide (EPIL);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • GST|His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INSL4-319H Recombinant Human INSL4 protein(Met1-Thr139), His-tagged HEK293 C-His Met1-Thr139
Human INSL4-118H Recombinant Human INSL4, His-tagged HEK293 His
Human INSL4-723H Recombinant Human INSL4 Protein, GST-His-tagged E.coli GST/His
Human INSL4-001HCL Recombinant Human INSL4 cell lysate Human Cell N/A
Human INSL4-3117H Recombinant Human INSL4 Protein (Ala26-Thr139), C-His tagged Mammalian cells C-His Ala26-Thr139
Human INSL4-5984HF Recombinant Full Length Human INSL4 Protein, GST-tagged In Vitro Cell Free System GST 26-139 amino acids
Human INSL4-5096H Recombinant Human INSL4 Protein, GST-tagged Wheat Germ GST
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • INSL4 Related Articles
  • INSL4 Related Research Area

INSL4 involved in several pathways and played different roles in them. We selected most pathways INSL4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with INSL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

INSL4 has several biochemical functions, for example, hormone activity, insulin-like growth factor receptor binding, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INSL4 itself. We selected most functions INSL4 had, and list some proteins which have the same functions with INSL4. You can find most of the proteins on our site.

Function Related Protein
hormone activityFNDC5;BMP10;IGF3;GCG;INHBA;C19orf80;GPHA2;PRL8A9;PRL2C2
insulin-like growth factor receptor bindingRen1;IRS1;INS;GNAS;YWHAG;INS2;SHC1;IGF3;SOCS2
receptor bindingHNF4A;TNFSF18;SRPX2;HAND2;TRIM24;ABCA1;FGF12A;CADM1B;ANGPT2

INSL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INSL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of INSL4.

Bruni, L; Luisi, S; et al. Changes in the maternal serum concentration of proearly placenta insulin-like growth factor peptides in normal vs abnormal pregnancy. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 197:-(2007).
Mock, P; Frydman, R; et al. Expression of Pro-EPIL peptides encoded by the insulin-like 4 (INSL4) gene in chromosomally abnormal pregnancies.. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 85:3941-3944(2000).
  • Q&As
  • Reviews

Q&As (7)

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Are there therapeutic implications associated with modulating INSL4 activity? 08/28/2022

Modulating INSL4 activity could have therapeutic implications for conditions related to reproductive health and pregnancy.

How does INSL4 expression change in pathological conditions, such as preeclampsia? 04/06/2022

In pathological conditions like preeclampsia, there are alterations in INSL4 expression levels, indicating a potential link to pregnancy-related complications.

Are there any genetic variations in the INSL4 gene associated with reproductive outcomes? 06/01/2021

Research indicates genetic variations in the INSL4 gene may be linked to recurrent pregnancy loss and fertility issues.

Is there a relationship between INSL4 and endometrial receptivity? 10/01/2019

INSL4 is associated with endometrial receptivity, particularly during the window of implantation, suggesting involvement in successful pregnancy establishment.

What are the potential functions of INSL4 during early embryonic development? 04/02/2019

INSL4 may play a role in early embryonic development, potentially influencing processes like blastocyst implantation and embryo-maternal communication.

Is INSL4 involved in any non-reproductive physiological processes? 07/03/2018

While primarily associated with reproductive processes, INSL4 may have additional roles in non-reproductive physiological processes, warranting further investigation.

What is the impact of INSL4 on trophoblast invasion and placental development? 05/13/2018

INSL4 influences trophoblast invasion, contributing to placental development, a critical aspect of successful pregnancy.

Customer Reviews (3)

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Reviews
03/24/2022

    Tailoring the product to our unique experimental conditions enhanced the precision of our results.

    10/10/2020

      The longevity of the product's effects allowed us to study cellular responses over extended timeframes.

      12/12/2019

        We found that the product's support for data analysis and visualization significantly expedited our research.

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