ip6k2
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  • Official Full Name
  • Inositol Hexakisphosphate Kinase 2
  • Background
  • This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • PIUS; IHPK2; IP6K2; inositol hexakisphosphate kinase 2; insp6 kinase 2; OTTHUMP00000164824; OTTHUMP00000210210; OTTHUMP00000210211; OTTHUMP00000210215; OTTHUMP00000210229; OTTHUMP00000210234; pi uptake stimulator; inositol hexaphosphate kinase 2; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase
Cat.#:IP6K2-503HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IP6K2 Protein, His-tagged
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Cat.#:IP6K2-8257MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IP6K2 Protein
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Cat.#:IP6K2-3085RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IP6K2 Protein
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Cat.#:IP6K2-2309CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IP6K2
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Cat.#:IP6K2-11516ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IP6K2
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Cat.#:IP6K2-5186HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IP6K2 293 Cell Lysate
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Involved Pathway

IP6K2 involved in several pathways and played different roles in them. We selected most pathways IP6K2 participated on our site, such as Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with IP6K2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phosphatidylinositol signaling system
INPP5A; PIK3R3A; PIP5K1AB; PTENA; PLCD3; PLCD1B; CDS2; INPP4AB; TMEM55A; MTMR7B

Protein Function

IP6K2 has several biochemical functions, for example, ATP binding, inositol hexakisphosphate 1-kinase activity, inositol hexakisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IP6K2 itself. We selected most functions IP6K2 had, and list some proteins which have the same functions with IP6K2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RIPK4; CLP1; TRIO; DMC1; ABCG1; SEPHS1; ITPKC; FGFR4; LIMK1; RAD51C
Function inositol hexakisphosphate 1-kinase activity
Related Protein IP6K3; PPIP5K1; IP6K2; PPIP5K2; IP6K1
Function inositol hexakisphosphate 3-kinase activity
Related Protein PPIP5K1; IP6K2; IP6K1; PPIP5K2; IP6K3
Function inositol hexakisphosphate 5-kinase activity
Related Protein IP6K3; PPIP5K2; IP6K2; PPIP5K1; IP6K1
Function inositol-1,4,5-trisphosphate 3-kinase activity
Related Protein IPMKB; IP6K3; ITPKB; ITPKA; IPMK; IP6K2; IP6K1; ITPKC
Function protein binding
Related Protein LPL; ARID3B; HPX; IRS4; ARHGEF1; FCN1; USP49; BBS2; MYH10; KCNA2

Interacting Protein

IP6K2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IP6K2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IP6K2.
MEOX2; RBPMS; PLSCR1; LNX2

IP6K2 Related Articles

Rao, F; Xu, J; et al. Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:1773-1778(2015).
Wang, HC; DeRose, EF; et al. IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. NATURE COMMUNICATIONS 5:-(2014).