irak2
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  • Official Full Name
  • interleukin-1 receptor-associated kinase 2
  • Background
  • Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/I
  • Synonyms
  • IRAK2; interleukin-1 receptor-associated kinase 2; interleukin-1 receptor-associated kinase-like 2; interleukin-1 receptor associated kinase-2; IRAK-2; MGC150550
Cat.#:IRAK2-5053HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IRAK2 Protein, GST-tagged
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Cat.#:IRAK2-27503THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IRAK2
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Cat.#:IRAK2-332HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IRAK2, GST-tagged, Active
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Cat.#:IRAK2-7069HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IRAK2 protein, His-tagged
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Cat.#:Irak2-7070MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Irak2 protein, His-tagged
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Cat.#:IRAK2-8293MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IRAK2 Protein
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Cat.#:IRAK2-3094RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IRAK2 Protein
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Cat.#:Irak2-7071RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Irak2 protein, His-tagged
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Cat.#:IRAK2-2317CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IRAK2
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Cat.#:IRAK2-1417HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human IRAK2 (Active), GST-tagged
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Cat.#:IRAK2-5171HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IRAK2 293 Cell Lysate
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Involved Pathway

IRAK2 involved in several pathways and played different roles in them. We selected most pathways IRAK2 participated on our site, such as Apoptosis, Neurotrophin signaling pathway, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
TNF; CASP7; CDK5RAP2; DCC; DBNLA; NTRK1; CSF2RB; IRF2A; NGF; STK24A
Neurotrophin signaling pathway
IRAK1; MAPK9; PIK3R3; MATK; SORT1; IRS1; MAPK7; RAP1A; GAB1; PIK3R5
Tuberculosis
MAPK13; Pla2r1; CAMK2D; IL10RB; MAPK9; cgr2b; IFNA13; FCGR3; ATP6V0B; TLR2

Protein Function

IRAK2 has several biochemical functions, for example, ATP binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IRAK2 itself. We selected most functions IRAK2 had, and list some proteins which have the same functions with IRAK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ANKK1; IARS; NVL; NUBPL; MYO7A; RPS6KA6; DNAH6; CDKL1; DCLK1A; MCCC2
Function protein binding
Related Protein ID1; CDC42EP1; USP13; GTF3C4; LDOC1; PTBP3; PXMP2; RAB3C; CDK13; STYK1
Function protein heterodimerization activity
Related Protein H2-AA; ATF3; KCNN1; HIST1H4G; POLE4; MAPK6; TAS1R3; ARNT; INHBA; H2BFWT
Function protein homodimerization activity
Related Protein KCNK3; BLOC1S6; SOD1; PTPRO; HSPB6; SLC9A7; CAMK2A; PYGB; HIF1AN; BCL2L2
Function protein serine/threonine kinase activity
Related Protein ERN2; ADCK5; TRIO; STK32C; TSSK5; TLK2; SQSTM1; LIMK2; TLK1B; CLK2

Interacting Protein

IRAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRAK2.
TRAF6; IRAK1; TIRAP; IRAK3; k7_vaccc; ARAF; STT3A; TARDBP; ZC3H12A

IRAK2 Related Articles

Furi, I; Sipos, F; et al. Association of Self-DNA Mediated TLR9-Related Gene, DNA Methyltransferase, and Cytokeratin Protein Expression Alterations in HT29-Cells to DNA Fragment Length and Methylation Status. SCIENTIFIC WORLD JOURNAL :-(2013).
Rosenbaek, LL; Assentoft, M; et al. Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. JOURNAL OF PHYSIOLOGY-LONDON 590:6121-6139(2012).
Ovsyannikova, I; Haralambieva, I; et al. The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity. HUMAN GENETICS 130:547-561(2011).