IRS1
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Official Full Name
insulin receptor substrate 1
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Overview
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009] -
Synonyms
IRS1; insulin receptor substrate 1; HIRS-1; IRS-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Sf9 Insect Cell
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|T7
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- IRS1 Related Articles
- IRS1 Related Gene Family
- IRS1 Related Research Area
- IRS1 Related Signal Pathway
IRS1 involved in several pathways and played different roles in them. We selected most pathways IRS1 participated on our site, such as cGMP-PKG signaling pathway, FoxO signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | FXYD2;MYH7;KCNJ8;SLC25A6;VDAC1;PIK3R2;NFATC2;CREB3L3;ROCK1 |
| FoxO signaling pathway | SMAD3A;MAPK1;G6PC3;KRAS;HOMER1;KLF2B;PRKAA2;CCND2;INSRA |
| mTOR signaling pathway | ULK2;ULK3;EIF4E2RS1;PIK3R3B;AKT3A;HIF1AB;EIF4BA;RPS6KB1;MLST8 |
| PIK-Akt signaling pathway | Ifna11;PTEN;IKBKG;CCNE1;TNC;TCL1;PDGFRA;ITGA1;FGF16 |
| AMPK signaling pathway | PPP2R3C;PFKP;G6PC2;TSC1;PFKFB4;Scd1;RAB2A;PIK3R2;CPT1A |
| Neurotrophin signaling pathway | IRS1;CAMK4;HRAS;MAPK9;RAP1A;PSEN1;NTF4;KRAS;MAP2K1 |
| Insulin signaling pathway | PHKB;CBL;PRKACAB;G6PC2;PRKCZ;PPP1R3C;INSR;FBP1;CALML5 |
| Adipocytokine signaling pathway | AKT1;POMCA;RELA;CPT1A;TNFRSF1A;ACSL4A;NFKBIB;ADIPOR1B;PTPN11A |
| Regulation of lipolysis in adipocytes | GNAI3;GNAI1;Adcy4;PIK3R3;NPR1;PRKG2;PIK3CB;NPY;PIK3R2 |
| Type II diabetes mellitus | INSR;IRS4;PIK3CD;PDX1;ADIPOQ;INS-IGF2;MAPK10;CACNA1G;TNF |
| Insulin resistance | PRKAG3B;IL6;GSK3B;MAPK8;TBC1D4;MLXIPL;PYGMA;PRKAB1A;TRIB3 |
| Non-alcoholic fatty liver disease (NAFLD) | FASLG;NDUFA1;RXRA;NDUFA6;NDUFB11;ADIPOR2;GSK3A;NDUFC2-KCTD14;DDIT3 |
| Aldosterone-regulated sodium reabsorption | KRAS;ATP1A2;ATP1B1;NR3C2;PIK3R3;PIK3R5;INSR;PIK3R1;MAPK1 |
| MicroRNAs in cancer | HOXD10;ITGA5;ZEB2;KIF23;ZEB1;CD44;HDAC4;ST14;TNN |
IRS1 has several biochemical functions, for example, SH2 domain binding, insulin receptor binding, insulin-like growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRS1 itself. We selected most functions IRS1 had, and list some proteins which have the same functions with IRS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH2 domain binding | IRS1;NUP62;MS4A2;SH3PXD2B;SYP;JAK2;LAX1;CTR9;DLC1 |
| insulin receptor binding | SNX1;DOK5;GRB10;SHC1;INS2;INS;IGF2;SNX4;DOK1B |
| insulin-like growth factor receptor binding | IGF1;INSR;GNAS;REN;IGF2B;SOCS2;IGF2;YWHAH;IGF2A |
| phosphatidylinositol 3-kinase binding | IRS2;IGF1R;TYRO3;IRS4;INSRB;CALM1;ATP1A1;PDGFRB;FYN |
| protein binding | RAD1;MFF;TMED2;G6PD;RARRES2;ORM1;HOXA1;FAS;TGFB1 |
| protein kinase C binding | DACT3;PDLIM5;GLRX3;SDC4;HDAC9;AKT1;PLEK;IRS1;AKT2 |
| signal transducer activity | GNB2;RERG;RRH;GNG8;STAT3;TAS2R143;MGAA;HCAR1-1;OLFR867 |
| transmembrane receptor protein tyrosine kinase adaptor activity | PIK3R1;IRS1;SH2B2;DOK2;GAB2;SHC1;BLNK;TRAT1;FRS2 |
IRS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRS1.
PIK3R1; PIK3CA
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