ISCU
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Official Full Name
iron-sulfur cluster scaffold homolog (E. coli)
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Overview
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins.;They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors,;chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster;scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance;and myoglobinuria. -
Synonyms
ISCU; iron-sulfur cluster scaffold homolog (E. coli); iron-sulfur cluster assembly enzyme ISCU, mitochondrial; mitochondrial; 2310020H20Rik; HML; hnifU; Iron sulfur cluster assembly enzyme ISCU mitochondrial; Iron sulfur cluster scaffold homolog (E. coli); Iron sulfur cluster scaffold homolog; Iron-sulfur cluster assembly enzyme ISCU; IscU iron sulfur cluster scaffold homolog; ISCU_HUMAN; ISU2; MGC74517; NIFU; NifU like N terminal domain containing; NifU like N terminal domain containing protein; NifU like protein; NifU-like N-terminal domain-containing protein; NifU-like protein; NIFUN; Nitrogen fixation cluster like; OTTHUMP00000238760; OTTHUMP00000238761; OTTHUMP00000238762; OTTHUMP00000238764; OTTHUMP00000238765; IscU iron-sulfur cluster scaffold homolog; RGD1309562;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Human
- Mouse
- Rhesus Macaque
- E. coli or Yeast
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Yeast
- GST
- His
- His (Fc)
- Avi
- Myc
- sumostar
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ISCU Related Articles
ISCU involved in several pathways and played different roles in them. We selected most pathways ISCU participated on our site, such as Metabolism, Mitochondrial iron-sulfur cluster biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISCU were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | ABHD14B;ADAL;COL4A3BP;CYB5A;ACMSD;NUDT3A;TYMP;SACM1LB;ATP5L |
| Mitochondrial iron-sulfur cluster biogenesis | ISCUB;LYRM4;ISCU |
ISCU has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ISCU itself. We selected most functions ISCU had, and list some proteins which have the same functions with ISCU. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 2 iron, 2 sulfur cluster binding | UQCRFS1;CIAPIN1;ISCU;CISD2;GLRX2;FDX1;FDX1B;ISCA2;XDH |
| 4 iron, 4 sulfur cluster binding | NDUFS8A;ETFDH;RSAD1;EXO5;DEM1;DDX11;NDUFS7;ISCUB;NFU1 |
| ferrous iron binding | ALKBH2;HEPH;EGLN2;ISCA2;ISCUB;TRR1;BCO1;FECH;ACP5 |
| iron ion binding | HBE1;CYP4V2;CYP2P10;BA1;ALOX5B.3;CYP2C38;FBXL5;CYP8B3;CYP2AA9 |
| iron-sulfur transferase activity | ISCUB;ISCU |
| protein binding | CCDC53;ARHGEF3;C19orf44;CDC20;HDAC10;BCL2L11;RTDR1;SMARCA2;CTGF |
| protein complex scaffold | HOMER1;GNB2L1;WWC1;DISC1;MAGI3;SLC9A3R2;AKAP13;PKP2;CHCHD3 |
ISCU has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISCU here. Most of them are supplied by our site. Hope this information will be useful for your research of ISCU.
NECAB2; HPRT1; CCDC172; NUP62; GOLGA2; IKZF1; KRT40
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