isg15
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  • Official Full Name
  • ISG15 ubiquitin-like modifier
  • Background
  • The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
  • Synonyms
  • ISG15; ISG15 ubiquitin-like modifier; G1P2; IP17; UCRP; IFI15; hUCRP; ubiquitin-like protein ISG15; ubiquitin cross-reactive protein; interferon-stimulated protein, 15 kDa; interferon-induced 17-kDa/15-kDa protein; interferon, alpha-inducible protein (clone IFI-15K);
Cat.#:ISG15-431MTag:His-GFP
Source (Host):BacteriaSpecies:Mouse
Product nameRecombinant Mouse ISG15 Protein, His-GFP-tagged
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Cat.#:ISG15-4606HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ISG15 Protein, GST-tagged
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Cat.#:ISG15-191HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISG15
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Cat.#:ISG15-242HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ISG15
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Cat.#:ISG15-258HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human ISG15, StrepII-tagged
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Cat.#:ISG15-28645THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISG15
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Cat.#:ISG15-28728THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISG15
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Cat.#:ISG15-551HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISG15 Protein, His-tagged
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Cat.#:ISG15-61HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human ISG15 protein, His-tagged
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Cat.#:Isg15-83HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Isg15, None tagged
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Cat.#:Isg15-1868MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Isg15 protein, His-tagged
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Cat.#:ISG15-2306RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ISG15 Protein, His-tagged
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Cat.#:ISG15-8009ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ISG15
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Cat.#:ISG15-29HTag:Calmodulin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISG15 Ubiquitin-Like Modifier, Calmodulin-Tagged
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Cat.#:ISG15-5152HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ISG15 293 Cell Lysate
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Involved Pathway

ISG15 involved in several pathways and played different roles in them. We selected most pathways ISG15 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISG15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RIG-I-like receptor signaling pathway
NT5C3; IL-8; NFKBIAA; RIPK1; NFKBIA; MAPK14B; DDX3; MAPK12; IFNA21; IFNPHI1

Protein Function

ISG15 has several biochemical functions, for example, protein binding, protein tag. Some of the functions are cooperated with other proteins, some of the functions could acted by ISG15 itself. We selected most functions ISG15 had, and list some proteins which have the same functions with ISG15. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein LCE3E; SLC22A2; STK11; ATP6V1C1; BMP1; FRMD8; MTMR7; DNER; MBD3; AGTR1
Function protein tag
Related Protein SUMO2; RNF41; SUMO1; SUMO3B; SUMO3A; NFATC2IP; ISG15; SUMO2B; SUMO3; UBL5

Interacting Protein

ISG15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISG15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISG15.
UBA7; USP18; FLNB; PPM1B; ELF3

ISG15 Related Articles

Baez-Santos, YM; St John, SE; et al. The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds. ANTIVIRAL RESEARCH 115:21-38(2015).
Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).