isl1
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  • Official Full Name
  • ISL LIM homeobox 1
  • Background
  • This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ISL1; ISL LIM homeobox 1; Isl-1; ISLET1; insulin gene enhancer protein ISL-1; islet-1; ISL1 transcription factor, LIM/homeodomain;
Cat.#:ISL1-5015HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ISL1 Protein, GST-tagged
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Cat.#:ISL1-129HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISL1
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Cat.#:ISL1-149HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISL1 protein, Arginine-tagged
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Cat.#:ISL1-28841THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ISL1
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Cat.#:ISL1-3102RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ISL1 Protein
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Cat.#:ISL1-6965CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ISL1
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Cat.#:ISL1-8599ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ISL1
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Cat.#:ISL1-5149HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ISL1 293 Cell Lysate
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Involved Pathway

ISL1 involved in several pathways and played different roles in them. We selected most pathways ISL1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
WNT1; WNT9B; HAND1; WNT7A; WNT2; FZD3; WNT3; AXIN1; PIK3CG; PCGF5

Protein Function

ISL1 has several biochemical functions, for example, RNA polymerase II activating transcription factor binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ISL1 itself. We selected most functions ISL1 had, and list some proteins which have the same functions with ISL1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II activating transcription factor binding
Related Protein EGR2; T; SIN3A; LMO2; NEUROD1; POU1F1; CTNNB1; TBX3; HNF4A; SMAD3
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TP73; CEBPG; ESR1; GATA1; RFX1A; MEOX2; NFATC4; NRL; MED8; SNAI3
Function RNA polymerase II transcription coactivator activity
Related Protein WBP2; CREBBP; NCOA1; SOX11; POU1F1; TRIM28; MEF2A; SOX12; CITED2; CITED1
Function bHLH transcription factor binding
Related Protein MAP3K10; ISL1; ASCL1; TCF4; SP1; RUNX2; TCF21; IKZF4; TCF3; SMAD3
Function chromatin binding
Related Protein NKX6; BARX2; SIRT6; TLE1; AJUBA; NKAP; EWSR1A; TOP2A; DLX3; CBFA2T3
Function enhancer sequence-specific DNA binding
Related Protein HMGB2; GATA1; MYT1; YY1; TFAP2B; GATA5; GATA4; LDB1; GATA3; FOXN4
Function estrogen receptor binding
Related Protein PHB2; ARRB1; XBP1; MMS19; TMEM38A; DDX17; PADI2; TRIP4; MED1; FUS
Function ligand-dependent nuclear receptor binding
Related Protein NCOA3; JUND; ISL1; TRIP4; C1D; NCOA1; BAZ2A; TRIM24; SRA1; MED1
Function protein binding
Related Protein GLI2; NUP62L; ERO1L; LRRC75A-AS1; MOB1A; GTPBP2; PRAC; TMIGD2; PRX; PFDN5
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein DLX3; DDIT3; LEF1; NKX2-8; MIXL1; PPARA; HOXA10; NFIB; POU1F1; STK16
Function zinc ion binding
Related Protein RNF34B; ALPI; GATAD2B; ZFP622; RNF34A; MYLIP; TET2; RNF25; CPA5; MARCH5L

Interacting Protein

ISL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISL1.
ZNF511; CDK6; KDM1A; PLCG2; CDKN2B; CRK; SMAD3; RELA

ISL1 Related Articles

Agaimy, A; Lell, M; et al. 'Neuroendocrine' middle ear adenomas: consistent expression of the transcription factor ISL1 further supports their neuroendocrine derivation. HISTOPATHOLOGY 66:182-191(2015).
Liu, J; Li, WQ; et al. Islet-1 Overexpression in Human Mesenchymal Stem Cells Promotes Vascularization Through Monocyte Chemoattractant Protein-3. STEM CELLS 32:1843-1854(2014).