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ITGB3BP

  • Official Full Name

    integrin beta 3 binding protein (beta3-endonexin)

  • Overview

    This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
  • Synonyms

    ITGB3BP; integrin beta 3 binding protein (beta3-endonexin); centromere protein R; CENPR; HSU37139; NRIF3; TAP20; Beta3 endonexin; CENP R; Integrin beta 3 binding protein; NRIF 3; Nuclear receptor interacting factor 3; TAP 20; beta 3 endonexin; beta-3-endonexin; OTTHUMP00000015392; OTTHUMP00000015409; OTTHUMP00000015410; integrin beta-3-binding protein; nuclear receptor-interacting factor 3; CENP-R;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGB3BP-543H Recombinant Human integrin beta 3 binding protein (beta3-endonexin), His-tagged E.coli His
Human ITGB3BP-180H Recombinant Human ITGB3BP, GST-tagged E.coli GST 1-177aa
Human ITGB3BP-5123HCL Recombinant Human ITGB3BP 293 Cell Lysate HEK293 N/A
Human ITGB3BP-2506H Recombinant Human ITGB3BP protein, His-tagged E.coli His 1-177 aa
Human ITGB3BP-5781HF Recombinant Full Length Human ITGB3BP Protein, GST-tagged In Vitro Cell Free System GST 177 amino acids
Human ITGB3BP-4975H Recombinant Human ITGB3BP Protein, GST-tagged Wheat Germ GST
Human ITGB3BP-1217H Recombinant Human ITGB3BP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGB3BP-1967HFL Recombinant Full Length Human ITGB3BP Protein, C-Flag-tagged Mammalian cells Flag
Human ITGB3BP-3126H Recombinant Human ITGB3BP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGB3BP-1217H-B Recombinant Human ITGB3BP Protein Pre-coupled Magnetic Beads HEK293
Mouse Itgb3bp-3607M Recombinant Mouse Itgb3bp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ITGB3BP-3115R Recombinant Rat ITGB3BP Protein Mammalian Cell His
Rat ITGB3BP-2771R-B Recombinant Rat ITGB3BP Protein Pre-coupled Magnetic Beads HEK293
Rat ITGB3BP-2771R Recombinant Rat ITGB3BP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ITGB3BP-3450C Recombinant Chicken ITGB3BP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ITGB3BP involved in several pathways and played different roles in them. We selected most pathways ITGB3BP participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB3BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell CyclePHF8;TGFB1A;CUL1A;SKA2;DYNC1I2;TRP53;SMAD2;RAD9;CENPK
Cell Cycle, MitoticCSNK1D;CDKN2D;NDEL1B;ITGB3BP;NDEL1;SET;CSNK1E;CENPN;CLIP1
Cell death signalling via NRAGE, NRIF and NADETIAM2;ARHGEF1A;CASP2;AATF;NET1;DCLRE1B;ARHGEF18;AKAP13;ITGB3BP
Chromosome MaintenanceDKC1;RUVBL2;RBBP4;DNA2;ACD;CENPI;CENPC1;OIP5;POT1A
Deposition of new CENPA-containing nucleosomes at the centromereCENPC1;MLF1IP;CENPP;CENPW;RBBP7;CENPL;OIP5;CENPK;CENPA
M PhaseDSN1;DULLARD;NUF2;NIPBLA;SMC4;CENPE;LEMD3;PDS5B;STAG1
Mitotic AnaphaseZW10;WAPAL;PDS5A;ZWINT;NSL1;CENPC1;SPC24;CENPE;CLIP1
Mitotic Metaphase and AnaphaseMIS12;ITGB3BP;PMF1;CENPK;CENPL;PDS5A;CDCA8;KNTC1;VRK1

ITGB3BP has several biochemical functions, for example, protein C-terminus binding, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB3BP itself. We selected most functions ITGB3BP had, and list some proteins which have the same functions with ITGB3BP. You can find most of the proteins on our site.

Function Related Protein
protein C-terminus bindingCLIC6;MAP3K7;ZBTB16;SDCBP;DAB2;EP300;TOP2A;SDCBP2;TAE1
protein bindingC21orf2;KRT6A;NFAT5;PRPF19;GLS;CD40;EMID2;NKAP;TLR1
signal transducer activityADRB2A;GNB1A;DKK1;OXTRL;CC2D1A;OLFR958;PLK2;PLCG2;LPAR2A

ITGB3BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB3BP here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB3BP.

ARFIP2; COL4A3BP; KIFC3; HIP1; SVIL; KDM1A; OFD1; WFS1; RECQL5; ALDH2; PDHA1; ACTG1

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