itgb3bp
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  • Official Full Name
  • integrin beta 3 binding protein (beta3-endonexin)
  • Background
  • This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • ITGB3BP; integrin beta 3 binding protein (beta3-endonexin); centromere protein R; CENPR; HSU37139; NRIF3; TAP20; Beta3 endonexin; CENP R; Integrin beta 3 binding protein; NRIF 3; Nuclear receptor interacting factor 3; TAP 20; beta 3 endonexin; beta-3-endonexin; OTTHUMP00000015392; OTTHUMP00000015409; OTTHUMP00000015410; integrin beta-3-binding protein; nuclear receptor-interacting factor 3; CENP-R
Cat.#:ITGB3BP-4975HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGB3BP Protein, GST-tagged
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Cat.#:ITGB3BP-180HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGB3BP, GST-tagged
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Cat.#:ITGB3BP-543HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human integrin beta 3 binding protein (beta3-endonexin), His-tagged
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Cat.#:ITGB3BP-3115RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITGB3BP Protein
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Cat.#:ITGB3BP-3450CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITGB3BP
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Cat.#:ITGB3BP-5123HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGB3BP 293 Cell Lysate
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Involved Pathway

ITGB3BP involved in several pathways and played different roles in them. We selected most pathways ITGB3BP participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cell death signalling via NRAGE, NRIF and NADE, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGB3BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
SMC3; ENSAA; MCM3L; SMC1AL; CCNA1; DMC1; CENPL; ORC2; CDKN1B; NEK2
Cell Cycle, Mitotic
SPDL1; DPF1; NDEL1A; CDK11B; PDS5A; RCC2; CENPE; RBBP4; RANGAP1B; NUPL2
Cell death signalling via NRAGE, NRIF and NADE
OBSCN; KALRNB; AATF; ARHGEF3; ITGB3BP; AKAP13; ECT2; NET1; CASP2; ABR
Chromosome Maintenance
POT1; CENPA; SMARCA5; OIP5; WRAP53; CENPO; CENPK; MIS18BP1; TERF2; CENPI
Deposition of new CENPA-containing nucleosomes at the centromere
MIS18BP1; CENPP; OIP5; MLF1IP; RBBP4; CENPL; MIS18A; ITGB3BP; CENPI; CENPW
M Phase
ENSAA; ENSAB; DULLARD; VRK2; NCAPD2; ZWINT; CENPI; SPC25; CENPH; MLF1IP
Mitotic Anaphase
ANKLE2; CENPH; MIS12; ERCC6L; RCC2; TMPO; NUF2; PDS5A; INCENP; SPDL1
Mitotic Metaphase and Anaphase
NDEL1; NUDC; AHCTF1; CENPI; B9D2; PMF1; NDEL1A; CENPQ; ANKLE2; SPDL1

Protein Function

ITGB3BP has several biochemical functions, for example, protein C-terminus binding, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGB3BP itself. We selected most functions ITGB3BP had, and list some proteins which have the same functions with ITGB3BP. You can find most of the proteins on our site.
Function
Related Protein
Function protein C-terminus binding
Related Protein MAPRE1; PRDX3; SP1; HOMER3; MED12; KCNIP3; PLEKHB1; TRP53; ERCC4; CALCOCO1
Function protein binding
Related Protein STAMBP; SCAF8; AMY1A; GNAT1; GRIN2D; ZC3H18; PDE6G; OAZ3; DIS3L; MOAP1
Function signal transducer activity
Related Protein ERG; GPR132B; VMN1R44; TMEM9B; GNG10; TMTOPS2A; MAPKAPK2; OLFR492; SHC3; OLFCG2

Interacting Protein

ITGB3BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGB3BP here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGB3BP.
ARFIP2; COL4A3BP; KIFC3; HIP1; SVIL; KDM1A; OFD1; WFS1; RECQL5; ALDH2; PDHA1; ACTG1