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ITIH2

  • Official Full Name

    inter-alpha-trypsin inhibitor heavy chain 2

  • Overview

    The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors;involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple;proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 (PubMed;2446322); Himmelfarb et al., 2004 (PubMed 14744536)).
  • Synonyms

    ITIH2; inter-alpha-trypsin inhibitor heavy chain 2; inter alpha (globulin) inhibitor, H2 polypeptide; inter-alpha-trypsin inhibitor heavy chain H2; H2P; Inter alpha globulin inhibitor H2 polypeptide; ITI HC2; OTTMUSP00000012019; AI747202; IGHEP2; Inter alpha (globulin) inhibitor H2; Inter alpha trypsin inhibitor complex component II; Inter alpha trypsin inhibitor heavy chain H2; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; Intin2; ITI heavy chain H2; ITI-HC2; Itih 2; ITIH2_HUMAN; OTTHUMP00000019058; OTTHUMP00000019059; RP23 119N4.3; Serum derived hyaluronan associated protein; Serum-derived hyaluronan-associated protein; SHAP; inter-alpha (globulin) inhibitor H2; inter-alpha (globulin) inhibitor, H2 polypeptide;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • KSI
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITIH2-5119HCL Recombinant Human ITIH2 293 Cell Lysate HEK293 N/A
Human ITIH2-1569H Recombinant Human ITIH2 protein, His & T7-tagged E.coli His/T7 Gly452~Asp702 (Accession # P19823)
Human ITIH2-1999H Recombinant Human ITIH2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITIH2-1021HFL Recombinant Full Length Human ITIH2 Protein, C-Flag-tagged Mammalian cells Flag
Human ITIH2-3126H Recombinant Human ITIH2 Protein (Gly452-Asp702), N-His tagged E.coli N-His Gly452-Asp702
Human ITIH2-1219H Recombinant Human ITIH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITIH2-1219H-B Recombinant Human ITIH2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Itih2-3612M Recombinant Mouse Itih2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bovine ITIH2-4336B Recombinant Bovine ITIH2 protein, His-KSI-tagged E.coli His-KSI 1-50aa
Zebrafish ITIH2-12249Z Recombinant Zebrafish ITIH2 Mammalian Cell His
Chicken ITIH2-3859C Recombinant Chicken ITIH2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITIH2 Related Articles
  • ITIH2 Related Research Area

ITIH2 involved in several pathways and played different roles in them. We selected most pathways ITIH2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ITIH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ITIH2 has several biochemical functions, for example, endopeptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITIH2 itself. We selected most functions ITIH2 had, and list some proteins which have the same functions with ITIH2. You can find most of the proteins on our site.

Function Related Protein
endopeptidase inhibitor activityMUG2;CST3;C3A.3;Serpina1c;SERPINA1D;C3;WFDC2;AHSG;Hc
serine-type endopeptidase inhibitor activitySERPINA1D;SPINT2;SERPINB1L1;MUG1;SPINK4;SPINK3;SERPINA6;SERPINH2;SERPINB10

ITIH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITIH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITIH2.

ATP5C1; d-mannose

Lin, BY; White, JT; et al. Deep depletion of abundant serum proteins reveals low-abundant proteins as potential biomarkers for human ovarian cancer. PROTEOMICS CLINICAL APPLICATIONS 3:853-861(2009).
Veeck, J; Chorovicer, M; et al. The extracellular matrix protein ITIH5 is a novel prognostic marker in invasive node-negative breast cancer and its aberrant expression is caused by promoter hypermethylation. ONCOGENE 27:865-876(2008).
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