itpk1
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  • Official Full Name
  • inositol-tetrakisphosphate 1-kinase
  • Background
  • Inositol-tetrakisphosphate 1-kinase is an enzyme that in humans is encoded by the ITPK1 gene.
  • Synonyms
  • ITPK1; inositol-tetrakisphosphate 1-kinase; inositol 1,3,4 triphosphate 5/6 kinase; ins(1,3,4)P(3) 5/6-kinase; inositol-triphosphate 5/6-kinase; inositol 1,3,4-triphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6 kinase; inositol 1,3,4-trisphosphate
Cat.#:ITPK1-4950HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITPK1 Protein, GST-tagged
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Cat.#:ITPK1-8385MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITPK1 Protein
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Cat.#:ITPK1-1959CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITPK1
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Cat.#:ITPK1-1351HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Inositol-Tetrakisphosphate 1-kinase, His-tagged
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Cat.#:ITPK1-5112HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITPK1 293 Cell Lysate
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Involved Pathway

ITPK1 involved in several pathways and played different roles in them. We selected most pathways ITPK1 participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3), D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
ITPKA; ITPK1; ITPKB
1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)
ITPK1
D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis
ITPK1
D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis
ITPK1
Factors involved in megakaryocyte development and platelet production
KIF5A; RACGAP1; KIF3C; CBX5; GATA6; KIF11; BA1; SH2B3; KIF3B; ZFPM2A
Hemostasis
SLC7A11; MFN2; RACGAP1; WDR1; GATA6; SERPINF2B; KIFC1; MGC173646; TFA; RHOGA
Inositol phosphate metabolism
PIK3CB; PTENA; INPP4AB; SYNJ2; ISYNA1; PLD4; TPI1A; ALDH6A1; INPP4A; PIK3CD
Metabolic pathways
UCK2B; IMPAD1; PGM1; HSD17B12B; PNP6; SDHD; IPPK; IDI2; DUT; PCYT1AB

Protein Function

ITPK1 has several biochemical functions, for example, ATP binding, catalytic activity, inositol tetrakisphosphate 1-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPK1 itself. We selected most functions ITPK1 had, and list some proteins which have the same functions with ITPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein FLT3; NETO2; TNK2; NAT10; TBK1; ATP2A3; PPP1CA; DAK; ABCA1; ATP6V1A
Function catalytic activity
Related Protein CKBB; HADHAA; PNP4B; DDAH2; MOSC2; ECI2; PHKA1; HYAL6; MTHFD1B; NDUFA9A
Function inositol tetrakisphosphate 1-kinase activity
Related Protein ITPK1A; ITPK1
Function inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity
Related Protein NT5DC3; SGPP2; PTPRQ; CTDSPL2B; SACM1LB; SACM1L; SACM1LA; TENC1; ITPK1; PXYLP1
Function inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity
Related Protein SACM1LA; NT5DC3; TENC1; PXYLP1; PTPRQ; ITPK1; CTDSPL2B; CTDSPL2A; SGPP2; SACM1LB
Function inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity
Related Protein ITPK1; SGPP2; SACM1LB; SACM1L; CTDSPL2A; TENC1; PXYLP1; NT5DC3; CTDSPL2B; PTPRQ
Function inositol-1,3,4-trisphosphate 5-kinase activity
Related Protein ITPK1A; ITPK1
Function inositol-1,3,4-trisphosphate 6-kinase activity
Related Protein ITPK1; ITPK1A
Function inositol-3,4,6-trisphosphate 1-kinase activity
Related Protein ITPK1
Function isomerase activity
Related Protein TOP1L; GPR19; PBLD2; PDIP5; PPIFA; PGAM1; PGAM1B; PPIAB; PGAM1A; TSTA3
Function magnesium ion binding
Related Protein DYRK3; ZNF143B; PSPH; FARS2; NT5C1A; DCTPP1; NT5C1B; WEE1; PKLR; PRPSAP1

Interacting Protein

ITPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPK1.
TRAF2; pi3p; CDC5L

ITPK1 Related Articles

Guan, Z; Wang, JH; et al. The Maternal ITPK1 Gene Polymorphism Is Associated with Neural Tube Defects in a High-Risk Chinese Population. PLOS ONE 9:-(2014).
Porcu, E; Medici, M; et al. A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function. PLOS GENETICS 9:-(2013).