ITPKA
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Official Full Name
inositol-trisphosphate 3-kinase A
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Overview
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro. -
Synonyms
ITPKA; inositol-trisphosphate 3-kinase A; inositol 1,4,5 trisphosphate 3 kinase A; IP3 3KA; IP3KA; IP3K A; IP3 3-kinase A; insP 3-kinase A; inositol 1,4,5-trisphosphate 3-kinase A; IP3-3KA;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc|DDK
- Involved Pathway
- Protein Function
- Interacting Protein
ITPKA involved in several pathways and played different roles in them. We selected most pathways ITPKA participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), Calcium signaling pathway, D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) | ITPKA;ITPKB;ITPK1 |
| Calcium signaling pathway | PDGFRA;PTGFR;TRHR2;GRIN2C;GRM1;SLC8A1;P2RX3;PHKB;NOS1 |
| D-myo-inositol (1,3,4)-trisphosphate biosynthesis | ITPKB;ITPKA |
| Inositol phosphate metabolism | PLCG2;INPP5E;ITPK1;PI4K2A;PLCD1;PIP5KL1;MTMR7;PIP5K1C;MTM1 |
| Metabolic pathways | MRI1;PTS;GALNTL1;NT5C3B;GPT2;POLR2C;GMDS;POLR3F;ASNS |
| Metabolism | NAT2;ARSK;COX10;APOBB.1;NUDT3;CYP2C18;B3GNT1;CPNE3;CPNE6 |
| Phosphatidylinositol signaling system | MTMR7A;PIP5K1BA;PIP5K1A;TMEM55A;ITPKB;ITPKC;PLCD1B;MTM1;PIK3CG |
| Synthesis of IP3 and IP4 in the cytosol | PLCD3;ITPKB;ITPKA |
ITPKA has several biochemical functions, for example, ATP binding, Rac GTPase binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKA itself. We selected most functions ITPKA had, and list some proteins which have the same functions with ITPKA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | IDE;ROCK1;KIF4;GSK3AB;DDX55;SIK2;ATP1A1A.5;FYNB;MLH1 |
| Rac GTPase binding | CORO1C;RAB7;NOXA1;SRGAP2;ARHGEF2;RAB7A;NCF2;ARHGAP4A;ARFIP2 |
| calmodulin binding | UBR4;ADD3;MYH7;TTN;SPATA17;MYO7A;TRPC2;MIP;MYO5C |
| calmodulin-dependent protein kinase activity | DCX;DAPK1;MYLK2;CAMK2D1;CAMK1D;CAMK2A;CAMK2B;MKNK2A;MAPKAPK2B |
| inositol-1,4,5-trisphosphate 3-kinase activity | ITPKC;ITPKA;IP6K1;IP6K2;IP6K3;ITPKB;IPMKB;IPMK |
ITPKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKA here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKA.
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