itpka
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  • Official Full Name
  • inositol-trisphosphate 3-kinase A
  • Background
  • Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.
  • Synonyms
  • ITPKA; inositol-trisphosphate 3-kinase A; inositol 1,4,5 trisphosphate 3 kinase A; IP3 3KA; IP3KA; IP3K A; IP3 3-kinase A; insP 3-kinase A; inositol 1,4,5-trisphosphate 3-kinase A; IP3-3KA
Cat.#:ITPKA-2641HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITPKA Protein, MYC/DDK-tagged
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Cat.#:ITPKA-190HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITPKA, GST-tagged
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Cat.#:ITPKA-8386MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITPKA Protein
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Cat.#:ITPKA-3123RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITPKA Protein
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Cat.#:ITPKA-6444CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ITPKA
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Involved Pathway

ITPKA involved in several pathways and played different roles in them. We selected most pathways ITPKA participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), Calcium signaling pathway, D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
ITPKA; ITPKB; ITPK1
Calcium signaling pathway
LTB4R2; PLCD4; PPP3R1; P2RX4B; TNNC2; EDNRB; P2RX7; PHKA1; ORAI3; PLCZ1
D-myo-inositol (1,3,4)-trisphosphate biosynthesis
ITPKA; ITPKB
Inositol phosphate metabolism
PIP5K2; PLCB1; MTMR1A; PIK3CD; PI4KA; OCRL; PIP5K1A; PLCH1; PLCD3A; MTMR7A
Metabolic pathways
GUK1B; ATP6V0A2B; CHIA; POLA1; ENO3; DPM3; HYAL6; PRODH2; IDH3G; TYMP
Metabolism
ACOT7; CBLC-1; CHST14; PLD6; AS3MT; AMD2; B3GNT1; GLYATL1; SLC25A21; CYP2AD6
Phosphatidylinositol signaling system
PIK3CA; PI4K2B; CALM1; TMEM55A; PIP5K1A; PIP5K1C; ITPKC; IMPAD1; PIK3CB; ITPKB
Synthesis of IP3 and IP4 in the cytosol
PLCD3; ITPKB; ITPKA

Protein Function

ITPKA has several biochemical functions, for example, ATP binding, Rac GTPase binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKA itself. We selected most functions ITPKA had, and list some proteins which have the same functions with ITPKA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SUPV3L1; NWD1; ACSL4; ERCC6L2; PCXA; MELK; YARS; AK7B; RAD51B; CCT8L2
Function Rac GTPase binding
Related Protein DVL1; CDKL5; SOD1; NOXA1; DOCK7; PAK2B; EPS8; MAP3K11; RCC2; PAK7
Function calmodulin binding
Related Protein KCNN2; MAPKAPK2; KCNN1B; PHKA2; ADD3; PPP3CA; MAP6; KCNH5; OBSCN; RIT2
Function calmodulin-dependent protein kinase activity
Related Protein MKNK2B; MYLK3; MAPKAPK2B; MKNK2; CAMKK2; MYLK2; CAMKK1; DAPK1; DCX; CAMK2G
Function inositol-1,4,5-trisphosphate 3-kinase activity
Related Protein IPMKB; IP6K2; ITPKC; ITPKB; ITPKA; IP6K1; IP6K3; IPMK

Interacting Protein

ITPKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKA here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKA.
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