itpkb
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  • Official Full Name
  • inositol-trisphosphate 3-kinase B
  • Background
  • The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.
  • Synonyms
  • ITPKB; inositol-trisphosphate 3-kinase B; inositol 1,4,5 trisphosphate 3 kinase B; IP3 3KB; IP3KB; 1D myo inositol trisphosphate 3 kinase B; Inositol 1 4 5 trisphosphate 3 kinase B; Inositol trisphosphate 3 kinase B; IP3 3 kinase; IP3 3 kinase B; IP3K; IP3K B; PIG 37; PIG37; Proliferation inducing protein 37; IP3 3-kinase B; insP 3-kinase B; OTTHUMP00000035705; proliferation-inducing protein 37; inositol 1,4,5-trisphosphate 3-kinase B; IP3K-B; IP3-3KB
Cat.#:ITPKB-591HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITPKB Protein (442-946 aa), His-SUMO-tagged
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Cat.#:ITPKB-4949HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITPKB Protein, GST-tagged
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Cat.#:ITPKB-3124RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITPKB Protein
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Cat.#:ITPKB-883HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITPKB cell lysate
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Involved Pathway

ITPKB involved in several pathways and played different roles in them. We selected most pathways ITPKB participated on our site, such as 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian), Calcium signaling pathway, D-myo-inositol (1,3,4)-trisphosphate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
ITPKB; ITPKA; ITPK1
Calcium signaling pathway
PLCZ1; HTR2A; PPIFA; EDNRA; CALM4; AGTR1B; ITPKA; ERBB2; PPP3CCB; TACR3L
D-myo-inositol (1,3,4)-trisphosphate biosynthesis
ITPKA; ITPKB
Inositol phosphate metabolism
IP6K3; PLCB1; ISYNA1; NUDT3; PLCE1; PIP4K2A; ITPKB; MTMR4; INPP5L; INPP4A
Metabolic pathways
REV3L; AMDHD1; PNLIPRP1; ATP6V1H; DDOST; MTHFD2; DAO; ATP5G3B; NSDHL; SDHDA
Metabolism
PDP2; Agmo; OAZ1; SLC25A32; LSM1; SLC35B2; PNPLA8; ADA; PTPMT1; CYP2F1
Phosphatidylinositol signaling system
CALM2B; DGKZ; PIP4K2A; CALM1; PLCD1; CALM; INPP4B; ITPR3; INPP5KA; IP6K1
Synthesis of IP3 and IP4 in the cytosol
ITPKA; PLCD3; ITPKB

Protein Function

ITPKB has several biochemical functions, for example, ATP binding, calmodulin binding, inositol-1,4,5-trisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKB itself. We selected most functions ITPKB had, and list some proteins which have the same functions with ITPKB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ADCK2; ASNA1; KIF23; PFKP; HSPE1; UBE2J2; RRM1; ABCB7; ABCC8; NLK2
Function calmodulin binding
Related Protein UBR4; SLC9A1; MAP6; MYO1A; NETO2; EPB41B; MYO6; CAMK1G; MYLK2; MYO1G
Function inositol-1,4,5-trisphosphate 3-kinase activity
Related Protein ITPKC; ITPKA; IPMKB; IP6K2; IP6K1; IPMK; IP6K3; ITPKB
Function protein binding
Related Protein RING1; SIN3A; SDC2; ZDHHC17; IFT20; SNRPA1; TGFBR2; DDX11; SWAP70; NHP2L1

Interacting Protein

ITPKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKB here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKB.
GOLGA2; PSME3; PDE4A; PDE4D; PDE4D; ADNP2; PIBF1; ESF1