itpkc
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  • Official Full Name
  • inositol-trisphosphate 3-kinase C
  • Background
  • This gene encodes a member of the inositol 1,4,5-trisphosphate (Ins(1,4,5)P(3)) 3-kinase family of enzymes that;catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is;localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide;polymorphisms in this gene are associated with Kawasaki disease.
  • Synonyms
  • ITPKC; inositol-trisphosphate 3-kinase C; inositol 1,4,5 trisphosphate 3 kinase C; IP3 3KC; IP3KC; Inositol trisphosphate 3 kinase C; InsP 3 kinase C; IP3K C; IP3 3-kinase C; insP 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase C; IP3-3KC
Cat.#:ITPKC-2639HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITPKC Protein, MYC/DDK-tagged
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Cat.#:ITPKC-4947HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITPKC Protein, GST-tagged
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Cat.#:ITPKC-192HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITPKC, GST-tagged
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Cat.#:ITPKC-8388MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITPKC Protein
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Cat.#:ITPKC-3125RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ITPKC Protein
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Cat.#:ITPKC-884HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITPKC cell lysate
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Involved Pathway

ITPKC involved in several pathways and played different roles in them. We selected most pathways ITPKC participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPKC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PLCG1; INPP5K; IPMK; PI4KAA; PLCD1A; PLCB2; PLCB1; ITPK1A; PIK3CG; INPPL1
Metabolic pathways
FUT9A; SCP2; UQCRH; ALDOA; STT3B; CYP2B6; DHRS3; ALPI.1; AGK; PLA2G5
Calcium signaling pathway
CALML5; GRIN1B; PLCB2; PHKG2; PPIFA; HTR5A; GRM1; PLCB3; SPHK1; AVPR1B
Phosphatidylinositol signaling system
MTMR7; PIKFYVE; DGKD; PIP5K1B; MTMR1A; CDS1; PIK3R3B; PIP4K2AA; CALM1A; PLCB2

Protein Function

ITPKC has several biochemical functions, for example, ATP binding, calmodulin binding, inositol-1,4,5-trisphosphate 3-kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPKC itself. We selected most functions ITPKC had, and list some proteins which have the same functions with ITPKC. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF2B; ATP2B3A; CMPK1; NEK10; PIK3R4; SRPK1A; NME4; FASTK; ATP6AP1; NADKD1
Function calmodulin binding
Related Protein MAP2; NDUFAF4; VAMP2; CAMSAP1; MYO5B; GRIN1; SPTBN1; REM1; TRPV5; MYH1B
Function inositol-1,4,5-trisphosphate 3-kinase activity
Related Protein IP6K3; IPMKB; IPMK; IP6K2; ITPKA; ITPKC; IP6K1; ITPKB

Interacting Protein

ITPKC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPKC here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPKC.
PPP3CC

ITPKC Related Articles

Rowley, AH; et al. Kawasaki Disease: Novel Insights into Etiology and Genetic Susceptibility. ANNUAL REVIEW OF MEDICINE, VOL 62, 2011 62:69-77(2011).